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Biodegradable pH-responsive hydrogels for controlled dual-drug release
Open accessAbstract
Dual-drug loaded pH-responsive hydrogels were prepared as a delivery system carrying, as exemplars, both anti-cancer and anti-bacterial agents for pH controlled drug release. The hydrogels were composed of poly(l-lactide)-co-polyethyleneglycol-co-poly(l-lactide) dimethacrylates (with various molecular weights of l-lactide oligomers) as a macromolecular crosslinker and copolymerized with acrylic acid and N-isopropylacrylamide. The biodegradability, biocompatibility and mechanical properties of the hydrogels were characterized with the hydrogels being nontoxic to cells, while showing a reversible >80% reduction in volume at pH 1.2 compared to pH 7.4. Drug release profiles showed differential release of tetracycline over doxorubicin at pH 1.2, with both drugs being released equally at pH 7.4. Biodegradability was tunable by altering the crosslinking density and pH, with the total degradation of the best gels observed within 2 weeks at pH 7.4.
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“The swelling-shrinking behavior of pH-responsive polymers in response to an external pH condition makes them suitable for drug delivery applications [38,39,40].”
From Review of Stimuli-Responsive Polymers in Drug Delivery and Textile Application (2019) · cites this paper as [39]
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Metadata
- Authors
- Xu, L., Qiu, L., Sheng, Y., Sun, Y., Deng, L., Li, X., Bradley, M., & Zhang, R.
- Affiliations
- Changzhou University (CN)
- Changzhou No.2 People's Hospital (CN)
- University of Edinburgh (GB)
- Corresponding author
- Zhang, Rong
- Venue
- Journal of Materials Chemistry B
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2018
- Volume
- 6
- Issue
- 3
- Pages
- 510-517
- ISSN
- 2050-750X (ISSN-L)
- 2050-7518
- OpenAlex
- W2772877544
- Cited by
- 128
- References
- 46
- Citations by year
- 2026: 13 · 2025: 16 · 2024: 15 · 2023: 21 · 2022: 12 · 2021: 22 · 2020: 13 · 2019: 13 · 2018: 3
- FWCI
- 3.05
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Materials Chemistry B (publishedVersion)
- PubMed (publishedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, cc-by)
- Funders
- Natural Science Foundation of Guangxi Province (2015GXNSFAA139255)
- Natural Science Foundation of Jiangsu Province (BK20160278)
- National Natural Science Foundation of China (11532003, 21374012, 51563003)
- Changzhou University (ZMF15020107)
- European Research Council (ERC-2013-ADG 340469 ADREEM)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- pH-responsive hydrogels, dual drug release, controlled drug delivery, poly(L-lactic acid), polyethylene glycol, N-isopropylacrylamide, acrylic acid, biodegradable polymers, tetracycline, doxorubicin, anticancer agents, antibacterial agents, crosslink density, biocompatibility, mechanical properties
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