Liposomal drug delivery systems: From concept to clinical applications
Abstract
The first closed bilayer phospholipid systems, called liposomes, were described in 1965 and soon were proposed as drug delivery systems. The pioneering work of countless liposome researchers over almost 5 decades led to the development of important technical advances such as remote drug loading, extrusion for homogeneous size, long-circulating (PEGylated) liposomes, triggered release liposomes, liposomes containing nucleic acid polymers, ligand-targeted liposomes and liposomes containing combinations of drugs. These advances have led to numerous clinical trials in such diverse areas as the delivery of anti-cancer, anti-fungal and antibiotic drugs, the delivery of gene medicines, and the delivery of anesthetics and anti-inflammatory drugs. A number of liposomes (lipidic nanoparticles) are on the market, and many more are in the pipeline. Lipidic nanoparticles are the first nanomedicine delivery system to make the transition from concept to clinical application, and they are now an established technology platform with considerable clinical acceptance. We can look forward to many more clinical products in the future.
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PEGylation helps liposomes escape the reticuloendothelial system and have a longer blood circulation time.
“PEG ylation helps liposomes escape the reticuloendothelial system and have a longer blood circulation time.49”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [49]
Liposomal drug delivery is an established platform with proven biocompatibility, but the oral route of administration is typically not used due to instability in the gastrointestinal tract.
“Although liposomal drug delivery is an established platform with proven biocompatibility, the oral route of administration is typically not used due to instability in the gastrointestinal tract 109 .”
From Nanotechnology approaches for global infectious diseases (2021) · cites this paper as [109]
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Liposomal Delivery Systems: Design Optimization and Current Applications
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- Authors
- Allen, T. M., & Cullis, P. R.
- Affiliations
- University of Alberta (CA)
- University of British Columbia (CA)
- Corresponding author
- Allen, Theresa M.
- ORCID
- Cullis, Pieter R.
- Venue
- Advanced Drug Delivery Reviews
- Publisher
- Elsevier BV
- Published
- 2013-01
- Volume
- 65
- Issue
- 1
- Pages
- 36-48
- ISSN
- 0169-409X (ISSN-L)
- OpenAlex
- W2076226743
- Cited by
- 4,839
- References
- 294
- Citations by year
- 2026: 348 · 2025: 470 · 2024: 367 · 2023: 324 · 2022: 378 · 2021: 406 · 2020: 380 · 2019: 415 · 2018: 414 · 2017: 400 · 2016: 379 · 2015: 279 · 2014: 211 · 2013: 65 · 2012: 1
- FWCI
- 9.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Advanced Drug Delivery Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research
- National Cancer Institute
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- liposomes, liposomal drug delivery, lipid nanoparticles, PEGylated liposomes, long-circulating liposomes, nucleic acid delivery, combination drug delivery, anticancer drug delivery, antifungal drug delivery, antibiotic delivery, gene therapy, anesthetic delivery, anti-inflammatory drug delivery, clinical translation, nanomedicine
- MeSH terms
- Animals, Drug Carriers, Pharmaceutical Preparations, Humans, Liposomes, Drug Delivery Systems, Nanomedicine, Nanoparticles
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