Cited by 4,839Nanoparticle-Based Drug DeliveryRNA Interference and Gene DeliveryAdvanced Drug Delivery Systems

Liposomal drug delivery systems: From concept to clinical applications

Allen, Theresa M., Cullis, Pieter R.·2013·Advanced Drug Delivery Reviews

Abstract

The first closed bilayer phospholipid systems, called liposomes, were described in 1965 and soon were proposed as drug delivery systems. The pioneering work of countless liposome researchers over almost 5 decades led to the development of important technical advances such as remote drug loading, extrusion for homogeneous size, long-circulating (PEGylated) liposomes, triggered release liposomes, liposomes containing nucleic acid polymers, ligand-targeted liposomes and liposomes containing combinations of drugs. These advances have led to numerous clinical trials in such diverse areas as the delivery of anti-cancer, anti-fungal and antibiotic drugs, the delivery of gene medicines, and the delivery of anesthetics and anti-inflammatory drugs. A number of liposomes (lipidic nanoparticles) are on the market, and many more are in the pipeline. Lipidic nanoparticles are the first nanomedicine delivery system to make the transition from concept to clinical application, and they are now an established technology platform with considerable clinical acceptance. We can look forward to many more clinical products in the future.

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Crossref · 10.1016/j.addr.2012.09.037

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285 of 285 references verified0 citation errors · 0 not checkable

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  • PEGylation helps liposomes escape the reticuloendothelial system and have a longer blood circulation time.

    “PEG ylation helps liposomes escape the reticuloendothelial system and have a longer blood circulation time.49”

    From Smart nanoparticles for cancer therapy (2023) · cites this paper as [49]

  • Liposomal drug delivery is an established platform with proven biocompatibility, but the oral route of administration is typically not used due to instability in the gastrointestinal tract.

    “Although liposomal drug delivery is an established platform with proven biocompatibility, the oral route of administration is typically not used due to instability in the gastrointestinal tract 109 .”

    From Nanotechnology approaches for global infectious diseases (2021) · cites this paper as [109]

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Authors
Allen, T. M., & Cullis, P. R.
Affiliations
  • University of Alberta (CA)
  • University of British Columbia (CA)
Corresponding author
Allen, Theresa M.
Venue
Advanced Drug Delivery Reviews
Publisher
Elsevier BV
Published
2013-01
Volume
65
Issue
1
Pages
36-48
ISSN
0169-409X (ISSN-L)
OpenAlex
W2076226743
Cited by
4,839
References
294
Citations by year
2026: 348 · 2025: 470 · 2024: 367 · 2023: 324 · 2022: 378 · 2021: 406 · 2020: 380 · 2019: 415 · 2018: 414 · 2017: 400 · 2016: 379 · 2015: 279 · 2014: 211 · 2013: 65 · 2012: 1
FWCI
9.07
Type
journal article
Language
en
Open access
closed
Locations
  • Advanced Drug Delivery Reviews (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Canadian Institutes of Health Research
  • National Cancer Institute
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Keywords
liposomes, liposomal drug delivery, lipid nanoparticles, PEGylated liposomes, long-circulating liposomes, nucleic acid delivery, combination drug delivery, anticancer drug delivery, antifungal drug delivery, antibiotic delivery, gene therapy, anesthetic delivery, anti-inflammatory drug delivery, clinical translation, nanomedicine
MeSH terms
Animals, Drug Carriers, Pharmaceutical Preparations, Humans, Liposomes, Drug Delivery Systems, Nanomedicine, Nanoparticles

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