Catalytic asymmetric synthesis of spirooxindoles: recent developments

Pyrrolidinyl‐Spirooxindole Natural Products as Inspirations for the Development of Potential Therapeutic Agents

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Isatins As Privileged Molecules in Design and Synthesis of Spiro-Fused Cyclic Frameworks

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Spirooxindoles: Promising scaffolds for anticancer agents

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Organocatalytic Asymmetric Assembly Reactions: Synthesis of Spirooxindoles via Organocascade Strategies

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Recent Advances in Asymmetric Organocatalytic Construction of 3,3′‐Spirocyclic Oxindoles

Hong, L., & Wang, R. (2013) · Advanced Synthesis & Catalysis · doi:10.1002/adsc.201200808 · Cited by 719 · see citing works

Chiral N , N ′-Dioxides: New Ligands and Organocatalysts for Catalytic Asymmetric Reactions

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Strategies for the enantioselective synthesis of spirooxindoles

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Organocatalytic Asymmetric Epoxidation and Aziridination of Olefins and Their Synthetic Applications

Zhu, Y., Wang, Q., Cornwall, R. G., & Shi, Y. (2014) · Chemical Reviews · doi:10.1021/cr500064w · Cited by 513 · see citing works

Therapeutic Potential of Spirooxindoles as Antiviral Agents

Ye, N., Chen, H., Wold, E. A., Shi, P., & Zhou, J. (2016) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.6b00041 · Cited by 493 · see citing works

Asymmetric Cycloaddition and Cyclization Reactions Catalyzed by Chiral N , N ′-Dioxide–Metal Complexes

Liu, X., Zheng, H., Xia, Y. M., et al. (2017) · Accounts of Chemical Research · doi:10.1021/acs.accounts.7b00377 · Cited by 485 · see citing works

Chiral N,N′-dioxide ligands: synthesis, coordination chemistry and asymmetric catalysis

Liu, X., Lin, L., & Feng, X. (2014) · Organic Chemistry Frontiers · doi:10.1039/c3qo00059a · Cited by 427 · see citing works

Recent advances in the synthesis of biologically active spirooxindoles

Santos, M. M. M. (2014) · Tetrahedron · doi:10.1016/j.tet.2014.08.005 · Cited by 400 · see citing works

Highly Stereoselective Olefin Cyclopropanation of Diazooxindoles Catalyzed by a C2-Symmetric Spiroketal Bisphosphine/Au(I) Complex

Cao, Z., Wang, X., Tan, C., et al. (2013) · Journal of the American Chemical Society · doi:10.1021/ja4040895 · Cited by 363 · see citing works

Molecular diversity of spirooxindoles. Synthesis and biological activity

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Asymmetric Catalytic Cascade Reactions for Constructing Diverse Scaffolds and Complex Molecules

Wang, Y., Lu, H., & Xu, P. (2015) · Accounts of Chemical Research · doi:10.1021/acs.accounts.5b00217 · Cited by 330 · see citing works

Asymmetric Synthesis of β-Lactams by Staudinger Ketene-Imine Cycloaddition Reaction

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Organocatalytic Domino Oxa‐Michael/1,6‐Addition Reactions: Asymmetric Synthesis of Chromans Bearing Oxindole Scaffolds

Zhao, K., Zhi, Y., Shu, T., et al. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201606947 · Cited by 255 · see citing works

Catalyst‐Controlled Switch in Chemo‐ and Diastereoselectivities: Annulations of Morita–Baylis–Hillman Carbonates from Isatins

Zhan, G., Shi, M., He, Q. G., et al. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201510825 · Cited by 232 · see citing works

Asymmetric Synthesis of β-Lactams Through the Staudinger Reaction and Their Use as Building Blocks of Natural and Nonnatural Products

Palomo, C., Aizpurua, J. M., Ganboa, I., et al. (2004) · Current Medicinal Chemistry · doi:10.2174/0929867043364900 · Cited by 210 · see citing works

A Catalytic Asymmetric Isatin-Involved Povarov Reaction: Diastereo- and Enantioselective Construction of Spiro[indolin-3,2′-quinoline] Scaffold

Shi, F. J., Xing, G., Zhu, R., et al. (2012) · Organic Letters · doi:10.1021/ol303154k · Cited by 199 · see citing works

Organocatalytic Direct Asymmetric Aldol Reactions of 3-Isothiocyanato Oxindoles to Ketones: Stereocontrolled Synthesis of Spirooxindoles Bearing Highly Congested Contiguous Tetrasubstituted Stereocenters

Chen, W., Wu, Z., Jing Hua, H. U., et al. (2011) · Organic Letters · doi:10.1021/ol200724q · Cited by 195 · see citing works

Catalytic asymmetric construction of spiropyrrolidines via 1,3-dipolar cycloaddition of azomethine ylides

Fang, X., & Wang, C. (2018) · Organic & Biomolecular Chemistry · doi:10.1039/c7ob02686b · Cited by 195 · see citing works

Recent Advances in Chiral Phosphoric Acid Catalyzed Asymmetric Reactions for the Synthesis of Enantiopure Indole Derivatives

Wu, H. Y., Shi, F. J., & He, Y. (2015) · Synthesis · doi:10.1055/s-0034-1378837 · Cited by 194 · see citing works

Synthesis of 3-substituted indoles via reactive alkylideneindolenine intermediates

Palmieri, A., Petrini, M., & Shaikh, R. R. (2009) · Organic & Biomolecular Chemistry · doi:10.1039/b919891a · Cited by 187 · see citing works

Indolylmethanols as Reactants in Catalytic Asymmetric Reactions

Mei, G., & Shi, F. J. (2017) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.7b01458 · Cited by 179 · see citing works

Diastereo- and Enantioselective Construction of 3,3′-Pyrrolidinyldispirooxindole Framework via Catalytic Asymmetric 1,3-Dipolar Cycloadditions

Dai, W., Jiang, X., Wu, Q., et al. (2015) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.5b00708 · Cited by 178 · see citing works

Discovery of orally active anticancer candidate CFI-400945 derived from biologically promising spirooxindoles: Success and challenges

Yu, B., Yu, Z., Qi, P., Yu, D., & Liu, H. (2015) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2015.03.020 · Cited by 171 · see citing works

Phosphine‐mediated Highly Enantioselective Spirocyclization with Ketimines as Substrates

Han, X., Chan, W., Yao, W., et al. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201600453 · Cited by 165 · see citing works

Asymmetric Triple Relay Catalysis: Enantioselective Synthesis of Spirocyclic Indolines through a One‐Pot Process Featuring an Asymmetric 6π Electrocyclization

Yin, X., Zeng, X., Liu, Y., et al. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201407677 · Cited by 163 · see citing works

Highly diastereo- and enantioselective construction of a spiro[cyclopenta[b]indole-1,3′-oxindole] scaffold via catalytic asymmetric formal [3+2] cycloadditions

Tan, W. W., Li, X., Gong, Y., et al. (2014) · Chemical Communications · doi:10.1039/c4cc07246d · Cited by 162 · see citing works

N-Heterocyclic carbene-catalyzed oxidative [3 + 2] annulation of dioxindoles and enals: cross coupling of homoenolate and enolate

Chen, X., Chen, K., Sun, D., et al. (2016) · Chemical Science · doi:10.1039/c6sc04135c · Cited by 159 · see citing works

Catalytic asymmetric chemoselective 1,3-dipolar cycloadditions of an azomethine ylide with isatin-derived imines: diastereo- and enantioselective construction of a spiro[imidazolidine-2,3′-oxindole] framework

Wang, Y., Zhang, H., Li, C., et al. (2015) · Chemical Communications · doi:10.1039/c5cc07924a · Cited by 156 · see citing works

Diastereo‐ and Enantioselective Construction of a Bispirooxindole Scaffold Containing a Tetrahydro‐β‐carboline Moiety through an Organocatalytic Asymmetric Cascade Reaction

Dai, W., Han, L., Li, X., et al. (2014) · Chemistry - A European Journal · doi:10.1002/chem.201402485 · Cited by 154 · see citing works

Catalytic functionalization of tertiary alcohols to fully substituted carbon centres

Chen, L., Yin, X., Wang, C., et al. (2014) · Organic & Biomolecular Chemistry · doi:10.1039/c4ob00718b · Cited by 150 · see citing works

Catalytic Asymmetric Formal [3+3] Cycloaddition of an Azomethine Ylide with 3‐Indolylmethanol: Enantioselective Construction of a Six‐Membered Piperidine Framework

Shi, F. J., Zhu, R., Dai, W., et al. (2014) · Chemistry - A European Journal · doi:10.1002/chem.201304187 · Cited by 150 · see citing works

Bifunctional N-Heterocyclic Carbene-Catalyzed Highly Enantioselective Synthesis of Spirocyclic Oxindolo-β-lactams

Zhang, H., Gao, Z., & Ye, S. (2014) · Organic Letters · doi:10.1021/ol501205v · Cited by 150 · see citing works

PyBidine–Cu(OTf)2‐Catalyzed Asymmetric [3+2] Cycloaddition with Imino Esters: Harmony of Cu–Lewis Acid and Imidazolidine‐NH Hydrogen Bonding in Concerto Catalysis

Arai, T., Ogawa, H., Awata, A., et al. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201410782 · Cited by 148 · see citing works

The asymmetric synthesis of CF 3 -containing spiro[pyrrolidin-3,2′-oxindole] through the organocatalytic 1,3-dipolar cycloaddition reaction

Ma, M., Zhu, Y., Sun, Q., et al. (2015) · Chemical Communications · doi:10.1039/c4cc10216a · Cited by 146 · see citing works

Asymmetric Michael/Cyclization Cascade Reaction of 3-Isothiocyanato Oxindoles and 3-Nitroindoles with Amino-Thiocarbamate Catalysts: Enantioselective Synthesis of Polycyclic Spirooxindoles

Zhao, J., Zhou, M., Wu, Z., et al. (2015) · Organic Letters · doi:10.1021/acs.orglett.5b00850 · Cited by 144 · see citing works

Asymmetric Organocatalytic Direct C(sp 2 )H/C(sp 3 )H Oxidative Cross‐Coupling by Chiral Iodine Reagents

Wu, H. Y., He, Y., Xu, L., et al. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201309967 · Cited by 137 · see citing works

Enantioselective Construction of Spiro[indoline-3,2′-pyrrole] Framework via Catalytic Asymmetric 1,3-Dipolar Cycloadditions Using Allenes as Equivalents of Alkynes

Wang, C.-S., Zhu, R., Zheng, J., et al. (2014) · The Journal of Organic Chemistry · doi:10.1021/jo502516e · Cited by 135 · see citing works

Regio‐ and Enantioselective Aza‐Diels–Alder Reactions of 3‐Vinylindoles: A Concise Synthesis of the Antimalarial Spiroindolone NITD609

Zheng, H., Liu, X., Xu, C., et al. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201505717 · Cited by 134 · see citing works

Engaging Allene‐Derived Zwitterions in an Unprecedented Mode of Asymmetric [3+2]‐Annulation Reaction

Sankar, M. G., García-Castro, M., Golz, C., et al. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201603936 · Cited by 133 · see citing works

Organocatalytic Asymmetric Synthesis of Six‐Membered Carbocycle‐Based Spiro Compounds

Xie, X., Huang, W., Peng, C. Y., et al. (2017) · Advanced Synthesis & Catalysis · doi:10.1002/adsc.201700927 · Cited by 133 · see citing works

Chiral Iodine‐Catalyzed Dearomatizative Spirocyclization for the Enantioselective Construction of an All‐Carbon Stereogenic Center

Zhang, D., Xu, L., Wu, H. Y., et al. (2015) · Chemistry - A European Journal · doi:10.1002/chem.201501583 · Cited by 132 · see citing works

A Highly Diastereo- and Enantioselective Hg(II)-Catalyzed Cyclopropanation of Diazooxindoles and Alkenes

Cao, Z., Zhou, F., Yu, Y., et al. (2012) · Organic Letters · doi:10.1021/ol302998m · Cited by 126 · see citing works

Natural Product-Derived Spirooxindole Fragments Serve as Privileged Substructures for Discovery of New Anticancer Agents

Yu, B., Zheng, Y., Shi, X., et al. (2016) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1871520615666151102093825 · Cited by 125 · see citing works

Recent Progress on Routes to Spirooxindole Systems Derived from Isatin

Xia, M., & Ma, R. (2013) · Journal of Heterocyclic Chemistry · doi:10.1002/jhet.1114 · Cited by 125 · see citing works

Catalytic Asymmetric [4+1] Cyclization of ortho ‐Quinone Methides with 3‐Chlorooxindoles

Jiang, X., Liu, S., Gu, Y., et al. (2017) · Advanced Synthesis & Catalysis · doi:10.1002/adsc.201700487 · Cited by 121 · see citing works

Catalytic asymmetric synthesis of polysubstituted spirocyclopropyl oxindoles: organocatalysis versus transition metal catalysis

Cao, Z., & Zhou, J. E. (2015) · Organic Chemistry Frontiers · doi:10.1039/c5qo00092k · Cited by 120 · see citing works

Zn-Catalyzed Diastereo- and Enantioselective Cascade Reaction of 3-Isothiocyanato Oxindoles and 3-Nitroindoles: Stereocontrolled Syntheses of Polycyclic Spirooxindoles

Zhao, J., Wu, Z., Zhou, M., Xu, X., Zhang, X., & Yuan, W. (2015) · Organic Letters · doi:10.1021/acs.orglett.5b02489 · Cited by 116 · see citing works

Switchable Access to Different Spirocyclopentane Oxindoles by N‐Heterocyclic Carbene Catalyzed Reactions of Isatin‐Derived Enals and N‐Sulfonyl Ketimines

Wang, L., Li, S., Blümel, M., et al. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201704210 · Cited by 116 · see citing works

Diastereo- and Enantioselective Dearomative [3 + 2] Cycloaddition Reaction of 2-Nitrobenzofurans with 3-Isothiocyanato Oxindoles

Zhao, J., Zhou, X., Zhou, Y., Xu, X., Zhang, X., & Yuan, W. (2018) · Organic Letters · doi:10.1021/acs.orglett.7b03667 · Cited by 115 · see citing works

An Organocatalytic Michael–Michael Cascade for the Enantioselective Construction of Spirocyclopentane Bioxindoles: Control of Four Contiguous Stereocenters

Sun, W., Hong, L., Zhu, G., Wang, Z., Wei, X., Ni, J., & Wang, R. (2014) · Organic Letters · doi:10.1021/ol4034226 · Cited by 114 · see citing works

Catalytic Asymmetric Tamura Cycloadditions

Manoni, F., & Connon, S. J. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201309297 · Cited by 113 · see citing works

Palladium-Catalyzed Asymmetric Cycloadditions of Vinylcyclopropanes and in Situ Formed Unsaturated Imines: Construction of Structurally and Optically Enriched Spiroindolenines

Liu, Z., Li, W., Kang, T., et al. (2014) · Organic Letters · doi:10.1021/ol503383x · Cited by 112 · see citing works

Nickel( ii )-catalyzed enantioselective cyclopropanation of 3-alkenyl-oxindoles with phenyliodonium ylide via free carbene

Guo, J., Liu, Y., Li, X., et al. (2016) · Chemical Science · doi:10.1039/c5sc03658e · Cited by 110 · see citing works

Spirooxindoles as Potential Pharmacophores

Panda, S. S., Jones, R. A., Bachawala, P., et al. (2017) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557516666160624125108 · Cited by 109 · see citing works

Phosphine-catalyzed asymmetric [4+1] annulation of activated α,β-unsaturated ketones with Morita–Baylis–Hillman carbonates: enantioselective synthesis of spirooxindoles containing two adjacent quaternary stereocenters

Hu, F., Wei, Y., & Shi, M. J. (2014) · Chemical Communications · doi:10.1039/c4cc03479a · Cited by 108 · see citing works

Asymmetric Construction of Spirooxindoles by Organocatalytic Multicomponent Reactions Using Diazooxindoles

Wu, M., He, W., Liu, X., et al. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201504640 · Cited by 108 · see citing works

Enantioselective Cascade Michael Addition/Cyclization Reactions of 3‐Nitro‐2H‐Chromenes with 3‐Isothiocyanato Oxindoles: Efficient Synthesis of Functionalized Polycyclic Spirooxindoles

Tan, F., Lu, L., Yang, Q., et al. (2014) · Chemistry - A European Journal · doi:10.1002/chem.201303583 · Cited by 107 · see citing works

Enantioselective Synthesis of Dihydrospiro[indoline-3,4′-pyrano[2,3-c]pyrazole] Derivatives via Michael/Hemiketalization Reaction

Kumarswamyreddy, N., & Kesavan, V. (2016) · Organic Letters · doi:10.1021/acs.orglett.6b00287 · Cited by 107 · see citing works

Brønsted Acid Catalyzed Asymmetric Diels–Alder Reactions: Stereoselective Construction of Spiro[tetrahydrocarbazole-3,3′-oxindole] Framework

Wang, Y., Tu, M., Yin, L., et al. (2015) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.5b00198 · Cited by 107 · see citing works

Organocatalytic Asymmetric Cascade Reactions of 7‐Vinylindoles: Diastereo‐ and Enantioselective Synthesis of C7‐Functionalized Indoles

Shi, F. J., Zhang, H., Sun, X., et al. (2014) · Chemistry - A European Journal · doi:10.1002/chem.201405245 · Cited by 106 · see citing works

A catalytic asymmetric construction of a tetrahydroquinoline-based spirooxindole framework via a diastereo- and enantioselective decarboxylative [4+2] cycloaddition

Mei, G., Li, D., Zhou, G.-X., et al. (2017) · Chemical Communications · doi:10.1039/c7cc05595a · Cited by 105 · see citing works

N-Heterocyclic Carbene Catalyzed [4 + 2] Annulation Reactions with in Situ Generated Heterocyclic ortho-Quinodimethanes

Xu, J., Yuan, S., & Miao, M. (2016) · Organic Letters · doi:10.1021/acs.orglett.6b01831 · Cited by 103 · see citing works

α-Regioselective Asymmetric [3 + 2] Annulations of Morita–Baylis–Hillman Carbonates with Cyclic 1-Azadienes and Mechanism Elucidation

Wang, K., Jin, T., Huang, X., et al. (2016) · Organic Letters · doi:10.1021/acs.orglett.6b00189 · Cited by 102 · see citing works

The Squaramide‐Catalyzed 1,3‐Dipolar Cycloaddition of Nitroalkenes with N‐2,2,2‐Trifluoroethylisatin Ketimines: An Approach for the Synthesis of 5′‐Trifluoromethyl‐spiro[pyrrolidin‐3,2′‐oxindoles]

Sun, Q., Li, X., Su, J., et al. (2015) · Advanced Synthesis & Catalysis · doi:10.1002/adsc.201500416 · Cited by 100 · see citing works

Origin of Stereoselectivity in Cooperative Asymmetric Catalysis Involving N-Heterocyclic Carbenes and Lewis Acids toward the Synthesis of Spirooxindole Lactone

Reddi, Y., & Sunoj, R. B. (2016) · ACS Catalysis · doi:10.1021/acscatal.6b03026 · Cited by 99 · see citing works

Meeting Organocatalysis with Drug Discovery: Asymmetric Synthesis of 3,3′-Spirooxindoles Fused with Tetrahydrothiopyrans as Novel p53-MDM2 Inhibitors

Wang, S., Jiang, Y., Wu, S., Dong, G., Miao, Z., Zhang, W., & Sheng, C. (2016) · Organic Letters · doi:10.1021/acs.orglett.6b00155 · Cited by 95 · see citing works

Enantioselective [4 + 1] Annulation Reactions of α-Substituted Ammonium Ylides To Construct Spirocyclic Oxindoles

Zheng, P., Ouyang, Q., Niu, S.-L., et al. (2015) · Journal of the American Chemical Society · doi:10.1021/jacs.5b04792 · Cited by 91 · see citing works

Recent Advances in Green Synthesis of 3,3′‐Spirooxindoles via Isatin–based One–pot Multicomponent Cascade Reactions in Aqueous Medium

Yan, L., & Wang, Y. (2016) · ChemistrySelect · doi:10.1002/slct.201601534 · Cited by 91 · see citing works

Recent Advances of α‐Isothiocyanato Compounds in the Catalytic Asymmetric Reaction

Han, W., Zhao, J., Zuo, J., et al. (2015) · Advanced Synthesis & Catalysis · doi:10.1002/adsc.201500264 · Cited by 89 · see citing works

Organocatalytic Asymmetric Michael/Cyclization Cascade Reactions of 3‑Hydroxyoxindoles/3-Aminooxindoles with α,β-Unsaturated Acyl Phosphonates for the Construction of Spirocyclic Oxindole-γ-lactones/lactams

Chen, L., Wu, Z., Zhang, M., et al. (2015) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.5b02253 · Cited by 89 · see citing works

Highly Enantioselective [3 + 2]-Annulation of Isatin-Derived Morita–Baylis–Hillman Adducts with Cyclic Sulfonimines

Wei, F., Huang, H.-Y., Zhong, N., Gu, C., Wang, D., & Liu, L. (2015) · Organic Letters · doi:10.1021/acs.orglett.5b00456 · Cited by 89 · see citing works

Asymmetric Tandem 1,5‐Hydride Shift/Ring Closure for the Synthesis of Chiral Spirooxindole Tetrahydroquinolines

Cao, W., Liu, X., Guo, J., et al. (2014) · Chemistry - A European Journal · doi:10.1002/chem.201404327 · Cited by 88 · see citing works

Catalytic Asymmetric 1,3‐Dipolar Cycloadditions of Alkynes with Isatin‐Derived Azomethine Ylides: Enantioselective Synthesis of Spiro[indoline‐3,2′‐pyrrole] Derivatives

Shi, F. J., Zhu, R., Liang, X., et al. (2013) · Advanced Synthesis & Catalysis · doi:10.1002/adsc.201300366 · Cited by 88 · see citing works

Asymmetric Synthesis of 3,3′-Spirooxindoles Fused with Cyclobutanes through Organocatalytic Formal [2 + 2] Cycloadditions under H-Bond-Directing Dienamine Activation

Qi, L., Yu, Y., Gui, Y., et al. (2014) · Organic Letters · doi:10.1021/ol503266q · Cited by 87 · see citing works

Organocatalytic asymmetric [3+2] cycloaddition of N-2,2,2-trifluoroethylisatin ketimines with 3-alkenyl-5-arylfuran-2(3H)-ones

Wang, Z., Wu, Z., Yue, D., et al. (2016) · Chemical Communications · doi:10.1039/c6cc06367e · Cited by 87 · see citing works

The asymmetric synthesis of polycyclic 3-spirooxindole alkaloids via the cascade reaction of 2-isocyanoethylindoles

Zhao, X., Liu, X., Xiong, Q., et al. (2015) · Chemical Communications · doi:10.1039/c5cc06353a · Cited by 84 · see citing works

The Application of N‐Protected 3‐Vinylindoles in Chiral Phosphoric Acid‐Catalyzed [3+2] Cyclization with 3‐Indolylmethanols: Monoactivation of the Catalyst to Vinyliminium

Fan, T., Zhang, H., Li, C., et al. (2016) · Advanced Synthesis & Catalysis · doi:10.1002/adsc.201501175 · Cited by 84 · see citing works

Asymmetric synthesis of trifluoromethyl-substituted 3,3′-pyrrolidinyl-dispirooxindoles through organocatalytic 1,3-dipolar cycloaddition reactions

Huang, W.-J., Chen, Q., Lin, N., et al. (2016) · Organic Chemistry Frontiers · doi:10.1039/c6qo00723f · Cited by 84 · see citing works

Hydrogen-Bond-Directed Formal [5 + 1] Annulations of Oxindoles with Ester-Linked Bisenones: Facile Access to Chiral Spirooxindole δ-Lactones

Zhao, S., Lin, J., Zhao, Y.-Y., et al. (2014) · Organic Letters · doi:10.1021/ol500547e · Cited by 82 · see citing works

Asymmetric synthesis of 3,3′-pyrrolidinyl-dispirooxindoles via a one-pot organocatalytic Mannich/deprotection/aza-Michael sequence

Zhao, K., Zhi, Y., Li, X., et al. (2015) · Chemical Communications · doi:10.1039/c5cc10057g · Cited by 81 · see citing works

Highly Stereoselective [3+2] Cycloadditions of Chiral Palladium‐Containing N1‐1,3‐Dipoles: A Divergent Approach to Enantioenriched Spirooxindoles

Li, T., Cheng, B., Fan, S., Wang, Y., Lu, L., & Xiao, W. (2016) · Chemistry - A European Journal · doi:10.1002/chem.201600735 · Cited by 81 · see citing works

Quinine-catalyzed asymmetric domino Michael-cyclization reaction for the synthesis of spirocyclic oxindoles bearing two spiro quaternary centers and three consecutive stereocenters

Cui, B., Li, S., Zuo, J., et al. (2014) · Tetrahedron · doi:10.1016/j.tet.2014.01.036 · Cited by 81 · see citing works

Direct enantioselective vinylogous aldol–cyclization cascade reaction of allyl pyrazoleamides with isatins: asymmetric construction of spirocyclic oxindole–dihydropyranones

Li, T.-Z., Jiang, Y., Guan, Y., et al. (2014) · Chemical Communications · doi:10.1039/c4cc04235b · Cited by 80 · see citing works

Efficient Catalytic Kinetic Resolution of Spiro‐epoxyoxindoles with Concomitant Asymmetric Friedel–Crafts Alkylation of Indoles

Zhu, G., Bao, G., Li, Y., et al. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201700494 · Cited by 80 · see citing works

Highly Enantioselective Tandem Michael Addition of Tryptamine‐Derived Oxindoles to Alkynones: Concise Synthesis of Strychnos Alkaloids

He, W., Hu, J., Wang, P., et al. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201800567 · Cited by 80 · see citing works

Imine and iminium precursors as versatile intermediates in enantioselective organocatalysis

Kataja, A. O., & Masson, G. (2014) · Tetrahedron · doi:10.1016/j.tet.2014.06.101 · Cited by 80 · see citing works

N-Heterocyclic Carbene-Catalyzed Formal [3 + 2] Annulation of α-Bromoenals with 3-Aminooxindoles: A Stereoselective Synthesis of Spirooxindole γ-Butyrolactams

Jiang, D., Dong, S., Tang, W., et al. (2015) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.5b02188 · Cited by 79 · see citing works

Thiourea–Quaternary Ammonium Salt Catalyzed Asymmetric 1, 3-Dipolar Cycloaddition of Imino Esters To Construct Spiro[pyrrolidin-3,3′-oxindoles]

Zhang, J., Wang, H., Jin, Q., et al. (2016) · Organic Letters · doi:10.1021/acs.orglett.6b02098 · Cited by 79 · see citing works

Enantioselective [2+2] annulation of simple aldehydes with isatin-derived ketimines via oxidative N-heterocyclic carbene catalysis

Xu, J., Yuan, S., Peng, J., et al. (2017) · Chemical Communications · doi:10.1039/c7cc01232b · Cited by 79 · see citing works

An asymmetric assembly of spirooxindole dihydropyranones through a direct enantioselective organocatalytic vinylogous aldol-cyclization cascade reaction of 3-alkylidene oxindoles with isatins

Han, J., & Chang, C. (2015) · Chemical Communications · doi:10.1039/c5cc08883f · Cited by 78 · see citing works

Amino Acid Derived Phosphine‐Catalyzed Enantioselective 1,4‐Dipolar Spiroannulation of Cyclobutenones and Isatylidenemalononitrile

Li, Y., Su, X., Zhou, W., et al. (2015) · Chemistry - A European Journal · doi:10.1002/chem.201406475 · Cited by 75 · see citing works

Enantioselective Construction of Tetrahydroquinolin-5-one-Based Spirooxindole Scaffold via an Organocatalytic Asymmetric Multicomponent [3 + 3] Cyclization

Zhu, Q., Zhang, Y., Xu, M., et al. (2016) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.6b01598 · Cited by 73 · see citing works

Asymmetric [3 + 2] Cycloaddition of 3-Amino Oxindole-Based Azomethine Ylides and α,β-Enones with Divergent Diastereocontrol on the Spiro[pyrrolidine-oxindoles]

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A catalytic asymmetric hetero-Diels–Alder reaction of olefinic azlactones and isatins: facile access to chiral spirooxindole dihydropyranones

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N-Heterocyclic carbene-catalyzed [4 + 2] annulation of α,β-unsaturated carboxylic acids: enantioselective synthesis of dihydropyridinones and spirocyclic oxindolodihydropyridinones

Jia, W., Zhang, H., Zhang, C., et al. (2015) · Organic Chemistry Frontiers · doi:10.1039/c5qo00301f · Cited by 71 · see citing works

Chiral Spirooxindole–Butenolide Synthesis through Asymmetric N-Heterocyclic Carbene-Catalyzed Formal (3 + 2) Annulation of 3-Bromoenals and Isatins

Zheng, C., Yao, W., Zhang, Y., & Ma, C. (2014) · Organic Letters · doi:10.1021/ol502365r · Cited by 70 · see citing works

Enantioselective Assembly of Spirocyclic Oxindole-dihydropyranones through NHC-Catalyzed Cascade Reaction of Isatins with N-Hydroxybenzotriazole Esters of α,β-Unsaturated Carboxylic Acid

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Organocatalytic cascade Michael/Michael reaction for the asymmetric synthesis of spirooxindoles containing five contiguous stereocenters

Zhao, B., & Du, D. (2016) · Chemical Communications · doi:10.1039/c6cc00705h · Cited by 69 · see citing works

Highly Enantioselective Control of Dynamic Cascade Transformations by Dual Catalysis: Asymmetric Synthesis of Polysubstituted Spirocyclic Oxindoles

Afewerki, S., Ma, G., Ibrahem, I., et al. (2015) · ACS Catalysis · doi:10.1021/cs501975u · Cited by 68 · see citing works

An NHC‐Catalyzed In Situ Activation Strategy to β‐Functionalize Saturated Carboxylic Acid: An Enantioselective Formal [3+2] Annulation for Spirocyclic Oxindolo‐γ‐butyrolactones

Xie, Y., Yu, C., Li, T., Tu, S., & Yao, C. (2015) · Chemistry - A European Journal · doi:10.1002/chem.201500345 · Cited by 68 · see citing works

Catalytic Asymmetric [3 + 2] Cyclization Reactions of 3-Isothiocyanato Oxindoles and Alkynyl Ketones Via an in Situ Generated Magnesium Catalyst

Wang, L., Yang, D., Li, D., et al. (2015) · Organic Letters · doi:10.1021/acs.orglett.5b02052 · Cited by 68 · see citing works

Organocatalytic [4+2] addition reactions via tetraenamine intermediate

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A cinchona alkaloid catalyzed enantioselective sulfa-Michael/aldol cascade reaction of isoindigos: construction of chiral bispirooxindole tetrahydrothiophenes with vicinal quaternary spirocenters

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Diastereo‐ and Enantioselective Synthesis of Chiral Pyrrolidine‐Fused Spirooxindoles via Organocatalytic [3+2] 1,3‐Dipolar Cycloaddition of Azomethine Ylides with Maleimides

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Synthesis of Chiral Spiro-Aziridine Oxindoles via Aza-Corey–Chaykovsky Reaction of Isatin Derived N-tert-Butanesulfinyl Ketimines

Hajra, S., Aziz, S. M., Jana, B., et al. (2016) · Organic Letters · doi:10.1021/acs.orglett.5b03564 · Cited by 65 · see citing works

Organocatalytic Asymmetric Biginelli-like Reaction Involving Isatin

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Substrate-controlled switchable asymmetric annulations to access polyheterocyclic skeletons

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Enantioselective Synthesis of the Spirotropanyl Oxindole Scaffold through Bimetallic Relay Catalysis

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A Mannich/cyclization cascade process for the asymmetric synthesis of spirocyclic thioimidazolidineoxindoles

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Enantioselective Construction of Spirocyclic Oxindoles via Tandem Michael/Michael Reactions Catalyzed by Multifunctional Quaternary Phosphonium Salt

Zhang, J., Cao, D., Wang, H., et al. (2016) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.6b01553 · Cited by 60 · see citing works

1-Hydroxybenzotriazole-Assisted, N-Heterocyclic Carbene Catalyzed β-Functionalization of Saturated Carboxylic Esters: Access to Spirooxindole Lactones

Xu, J., Yuan, S., Miao, M., et al. (2016) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.6b02032 · Cited by 60 · see citing works

Diastereodivergent asymmetric Michael-alkylation reactions using chiral N , N ′-dioxide/metal complexes

Kuang, Y., Shen, B., Dai, L., et al. (2017) · Chemical Science · doi:10.1039/c7sc02757e · Cited by 60 · see citing works

Synthesis of Spiro[chroman/tetrahydrothiophene‐3,3′‐oxindole] Scaffolds via Heteroatom‐Michael–Michael Reactions: Easily Controlled Enantioselectivity via Bifunctional Catalysts

Huang, Y., Zheng, C., Chai, Z., et al. (2014) · Advanced Synthesis & Catalysis · doi:10.1002/adsc.201300833 · Cited by 59 · see citing works

Asymmetric [3+2] Annulations to Construct 1,2‐Bispirooxindoles Incorporating a Dihydropyrrolidine Motif

He, Q. G., Du, W., & Chen, Y. (2017) · Advanced Synthesis & Catalysis · doi:10.1002/adsc.201700849 · Cited by 59 · see citing works

Squaramide‐Catalyzed Synthesis of Enantioenriched Spirocyclic Oxindoles via Ketimine Intermediates with Multiple Active Sites

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Asymmetric [3 + 2] Cycloaddition of Methyleneindolinones with N,N′-Cyclic Azomethine Imines Catalyzed by a N,N′-Dioxide–Mg(OTf)2 Complex

Yin, C., Lin, L., Zhang, D., et al. (2015) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.5b01760 · Cited by 57 · see citing works

Catalytic asymmetric construction of spiro[pyrrolidine-2,3′-oxindole] scaffolds through chiral phosphoric acid-catalyzed 1,3-dipolar cycloaddition involving 3-amino oxindoles

Zhu, G., Wang, B., Bao, X., et al. (2015) · Chemical Communications · doi:10.1039/c5cc05798a · Cited by 57 · see citing works

Asymmetric Synthesis of Spiro-epoxyoxindoles by the Catalytic Darzens Reaction of Isatins with Phenacyl Bromides

Kuang, Y., Lu, Y., Tang, Y., et al. (2014) · Organic Letters · doi:10.1021/ol501941n · Cited by 57 · see citing works

Diastereo- and Enantioselective Synthesis of Spirooxindoles with Contiguous Tetrasubstituted Stereocenters via Catalytic Coupling of Two Tertiary Radicals

Song, Z., Chen, K., Chen, X., et al. (2018) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.7b03161 · Cited by 57 · see citing works

Asymmetric Synthesis of 2′‐Trifluoromethylated Spiro‐pyrrolidine‐3,3′‐oxindoles via Squaramide‐Catalyzed Umpolung and 1,3‐Dipolar Cycloaddition

Su, J., Ma, Z., Li, X., et al. (2016) · Advanced Synthesis & Catalysis · doi:10.1002/adsc.201600688 · Cited by 56 · see citing works

A Tunable and Enantioselective Hetero‐Diels–Alder Reaction Provides Access to Distinct Piperidinoyl Spirooxindoles

Jayakumar, S., Louven, K., Strohmann, C., et al. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201708355 · Cited by 55 · see citing works

Asymmetric Synthesis of Spirocyclic Oxindole‐Fused Tetrahydrothiophenes via N,N′‐Dioxide–Nickel(II) Catalyzed Domino Reaction of 1,4‐Dithiane‐2,5‐diol with 3‐Alkenyloxindoles

Zhou, P., Cai, Y., Lin, L., et al. (2015) · Advanced Synthesis & Catalysis · doi:10.1002/adsc.201400964 · Cited by 54 · see citing works

Catalytic Kinetic Resolution of Spiro-Epoxyoxindoles with 1-Naphthols: Switchable Asymmetric Tandem Dearomatization/Oxa-Michael Reaction and Friedel–Crafts Alkylation of 1-Naphthols at the C4 Position

Zhu, G., Li, Y., Bao, G., et al. (2018) · ACS Catalysis · doi:10.1021/acscatal.7b03268 · Cited by 54 · see citing works

Organocatalytic Asymmetric Michael/Friedel–Crafts Cascade Reaction of 3-Pyrrolyl-oxindoles and α,β-Unsaturated Aldehydes for the Construction of Chiral Spiro[5,6-dihydropyrido[1,2-a]pyrrole-3,3′-oxindoles]

You, Y., Cui, B., Zhou, M., et al. (2015) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.5b00597 · Cited by 53 · see citing works

Catalytic Asymmetric Construction of 3,3′‐Spirooxindoles Fused with Seven‐Membered Rings by Enantioselective Tandem Reactions

Wang, Y., Shi, F. J., Yao, X., et al. (2014) · Chemistry - A European Journal · doi:10.1002/chem.201403868 · Cited by 53 · see citing works

Organocatalytic [3+2] Cycloadditions of Barbiturate‐Based Olefins with 3‐Isothiocyanato Oxindoles: Highly Diastereoselective and Enantioselective Synthesis of Dispirobarbiturates

Zhao, H., Tian, T., Pang, H., et al. (2016) · Advanced Synthesis & Catalysis · doi:10.1002/adsc.201600270 · Cited by 53 · see citing works

An organocatalytic domino Michael-alkylation reaction: highly enantioselective construction of spiro-cyclopentanoneoxindoles and tetronic acid scaffolds

Zhou, J., Wang, Q., Peng, L., et al. (2014) · Chemical Communications · doi:10.1039/c4cc05207b · Cited by 52 · see citing works

Asymmetric synthesis of drug-like spiro[chroman-3,3′-indolin]-2′-ones through aminal-catalysis

Ramachary, D. B., Prasad, M. S., Laxmi, S. V., et al. (2013) · Organic & Biomolecular Chemistry · doi:10.1039/c3ob42100g · Cited by 52 · see citing works

Enantioselective synthesis of spiro[indoline-3,4′-pyrano[2,3-c]pyrazole] derivatives via an organocatalytic asymmetric Michael/cyclization cascade reaction

Xie, J., Xing, X., Sha, F., et al. (2016) · Organic & Biomolecular Chemistry · doi:10.1039/c6ob01256f · Cited by 52 · see citing works

Highly Enantioselective Tandem Michael Addition of Tryptamine‐Derived Oxindoles to Alkynones: Concise Synthesis of Strychnos Alkaloids

He, W., Hu, J., Wang, P., et al. (2018) · Angewandte Chemie · doi:10.1002/ange.201800567 · Cited by 52 · see citing works

Organocatalytic enantioselective construction of multi-functionalized spiro oxindole dienes

Huang, X., Zhang, Y., Qi, Z., et al. (2014) · Organic & Biomolecular Chemistry · doi:10.1039/c4ob00545g · Cited by 51 · see citing works

The enantioselective construction of chiral spirooxindole-based 4-thiazolidinone via asymmetric catalytic formal [3+2] annulation using a bifunctional catalyst

Cheng, P., Guo, W., Chen, P., et al. (2016) · Chemical Communications · doi:10.1039/c5cc10292h · Cited by 51 · see citing works

Diastereo‐ and Enantioselective Construction of Dihydroisocoumarin‐Based Spirooxindole Frameworks via Organocatalytic Tandem Reactions

Wu, J., Du, B., Zhang, Y., et al. (2016) · Advanced Synthesis & Catalysis · doi:10.1002/adsc.201600271 · Cited by 51 · see citing works

Highly Stereoselective [4+2] and [3+2] Spiroannulations of 2‐(2‐Oxoindolin‐3‐ylidene)acetic Esters Catalyzed by Bifunctional Thioureas

Monari, M., Montroni, E., Nitti, A., Lombardo, M., Trombini, C., & Quintavalla, A. (2015) · Chemistry - A European Journal · doi:10.1002/chem.201500676 · Cited by 50 · see citing works

Catalytic Aldol–Cyclization Cascade of 3-Isothiocyanato Oxindoles with α-Ketophosphonates for the Enantioselective Synthesis of β-Amino-α-hydroxyphosphonates

Kayal, S., & Mukherjee, S. (2015) · Organic Letters · doi:10.1021/acs.orglett.5b02929 · Cited by 50 · see citing works

Enantioselective Vinylogous Michael/Cyclization Cascade Reaction of Acyclic β,γ‐Unsaturated Amides with Isatylidene Malononitriles: Asymmetric Construction of Spirocyclic Oxindoles

Li, T.-Z., Xie, J., Jiang, Y., et al. (2015) · Advanced Synthesis & Catalysis · doi:10.1002/adsc.201500469 · Cited by 49 · see citing works

N-heterocyclic carbene-catalyzed [4 + 2] cyclization of 2-bromo-2-enal with 3-alkylenyloxindoles: efficient assembly of spirocarbocyclic oxindole

Xie, Y., Que, Y., Li, T., et al. (2014) · Organic & Biomolecular Chemistry · doi:10.1039/c4ob01706d · Cited by 49 · see citing works

Catalytic enantioselective cascade Michael/cyclization reaction of 3-isothiocyanato oxindoles with exocyclic α,β-unsaturated ketones en route to 3,2′-pyrrolidinyl bispirooxindoles

Kayal, S., & Mukherjee, S. (2016) · Organic & Biomolecular Chemistry · doi:10.1039/c6ob02187e · Cited by 49 · see citing works

PyBidine–Ni(OAc)2-Catalyzed Michael/Aldol Reaction of Methyleneindolinones and Thiosalicylaldehydes for Stereochemically Divergent Thiochromanyl-spirooxindoles

Arai, T., Miyazaki, T., Ogawa, H., et al. (2016) · Organic Letters · doi:10.1021/acs.orglett.6b02783 · Cited by 49 · see citing works

Zinc‐Catalyzed Enantioselective Dearomative [3+2] Cycloaddition Reaction of 3‐Nitrobenzothiophenes and 3‐Nitrothieno[2,3‐b]yridine with 3‐Isothiocyanato Oxindoles

Yue, D., Zhao, J., Chen, Y., et al. (2018) · Advanced Synthesis & Catalysis · doi:10.1002/adsc.201701557 · Cited by 49 · see citing works

Enantio- and Diastereoselective Synthesis of Spiro-epoxyoxindoles

Boucherif, A., Yang, Q., Wang, Q., et al. (2014) · The Journal of Organic Chemistry · doi:10.1021/jo5003856 · Cited by 48 · see citing works

Synthesis of β-lactams by transition metal promoted Staudinger reactions: alternative synthetic approaches from transition metal enhanced organocatalysis to in situ, highly reactive intermediate synthesis and catalytic tandem reactions

Tuba, R. (2013) · Organic & Biomolecular Chemistry · doi:10.1039/c3ob41048j · Cited by 48 · see citing works

Phosphine‐Catalyzed Asymmetric Formal [4+2] Tandem Cyclization of Activated Dienes with Isatylidenemalononitriles: Enantioselective Synthesis of Multistereogenic Spirocyclic Oxindoles

Hu, F., Wei, Y., & Shi, M. J. (2014) · Advanced Synthesis & Catalysis · doi:10.1002/adsc.201301070 · Cited by 47 · see citing works

Water-Promoted Regiospecific Azidolysis and Copper-Catalyzed Azide–Alkyne Cycloaddition: One-Pot Synthesis of 3-Hydroxy-1-alkyl-3-[(4-aryl/alkyl-1H-1,2,3-triazol-1-yl)methyl]indolin-2-ones

Kumar, K., Konar, D., Goyal, S., et al. (2016) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.6b01819 · Cited by 47 · see citing works

Formal [3 + 2] cycloaddition of α-unsubstituted isocyanoacetates and methyleneindolinones: enantioselective synthesis of spirooxindoles

Peng, X.-J., Ho, Y. A., Wang, Z., Shao, P., Zhao, Y., & He, Y. (2016) · Organic Chemistry Frontiers · doi:10.1039/c6qo00555a · Cited by 47 · see citing works

Highly diastereo- and enantioselective synthesis of spirooxindole-cyclohexaneamides through N,N′-dioxide/Ni( ii )-catalyzed Diels–Alder reactions

Zhou, Y., Lu, Y., Hu, X., et al. (2017) · Chemical Communications · doi:10.1039/c6cc10125a · Cited by 46 · see citing works

Facile Synthesis of Chiral Spirooxindole‐Based Isotetronic Acids and 5‐1H‐Pyrrol‐2‐ones through Cascade Reactions with Bifunctional Organocatalysts

Guo, W., Wang, X., Zhang, B., Shen, S., Zhou, X., Wang, P., Liu, Y., & Li, C. (2014) · Chemistry - A European Journal · doi:10.1002/chem.201402945 · Cited by 45 · see citing works

N-Heterocyclic carbene-catalyzed [4 + 2] cyclization of α,β-unsaturated carboxylic acids bearing γ-H with isatins: an enantioselective synthesis of spirocyclic oxindole–dihydropyranones

Zhu, L., Yu, C., Li, T., Wang, Y., Lu, Y., Wang, W., & Yao, C. (2015) · Organic & Biomolecular Chemistry · doi:10.1039/c5ob02160j · Cited by 45 · see citing works

Highly Enantioselective Construction of Polycyclic Spirooxindoles by Organocatalytic 1,3‐Dipolar Cycloaddition of 2‐Cyclohexenone Catalyzed by Proline‐Sulfonamide

Xiao, J., Liu, Q., Ren, J., et al. (2014) · European Journal of Organic Chemistry · doi:10.1002/ejoc.201402953 · Cited by 44 · see citing works

Chiral N,N′-dioxide/Co( ii )-promoted asymmetric 1,3-dipolar cycloaddition of nitrones with methyleneindolinones

Zhang, D., Yin, C., Zhou, Y., et al. (2017) · Chemical Communications · doi:10.1039/c7cc03575f · Cited by 44 · see citing works

Remote Asymmetric Oxa-Diels–Alder Reaction of 5-Allylic Furfurals via Dearomatizative Tetraenamine Catalysis

He, X., Zhao, H., Duan, C., et al. (2018) · Organic Letters · doi:10.1021/acs.orglett.7b03942 · Cited by 44 · see citing works

Cinchona alkaloid thiourea mediated asymmetric Mannich reaction of isocyanoacetates with isatin-derived ketimines and subsequent cyclization: enantioselective synthesis of spirooxindole imidazolines

Zhao, M., Jing, L., Zhou, H., et al. (2015) · RSC Advances · doi:10.1039/c5ra17075c · Cited by 43 · see citing works

Organocatalytic Enantioselective Cascade Aza‐Michael/Michael Addition Sequence for Asymmetric Synthesis of Chiral Spiro[pyrrolidine‐3,3′‐oxindole]s

Zhao, B., & Du, D. (2015) · Asian Journal of Organic Chemistry · doi:10.1002/ajoc.201500306 · Cited by 43 · see citing works

Catalytic asymmetric hetero-Diels–Alder reactions of enones with isatins to access functionalized spirooxindole tetrahydropyrans: scope, derivatization, and discovery of bioactives

Cui, H., Chouthaiwale, P. V., Yin, F., et al. (2015) · Organic & Biomolecular Chemistry · doi:10.1039/c5ob02393a · Cited by 43 · see citing works

Organocatalytic One-Pot Asymmetric Synthesis of Thiolated Spiro-γ-lactam Oxindoles Bearing Three Stereocenters

Huang, X., Liu, M., Pham, K., Zhang, X., Yi, W., Jasinski, J. P., & Zhang, W. (2016) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.6b00653 · Cited by 43 · see citing works

Enantioselective 1,3-Dipolar Cycloaddition of Methyleneindolinones with α-Diazomethylphosphonate to Access Chiral Spiro-phosphonylpyrazoline-oxindoles Catalyzed by Tertiary Amine Thiourea and 1,5-Diazabicyclo[4.3.0]non-5-ene

Huang, N., Zou, L., & Peng, Y. (2017) · Organic Letters · doi:10.1021/acs.orglett.7b02763 · Cited by 43 · see citing works

Squaramide-catalyzed asymmetric Michael/cyclization cascade reaction of 3-isothiocyanato oxindoles with chalcones for synthesis of pyrrolidinyl spirooxindoles

Lin, Y., Liu, L., & Du, D. (2017) · Organic Chemistry Frontiers · doi:10.1039/c6qo00852f · Cited by 42 · see citing works

Asymmetric [3+2] cycloaddition of 3-amino oxindole-based azomethine ylides with α,β-ynones: a straightforward approach to spirooxindoles incorporating 2,5-dihydropyrroles and pyrroles

Zhu, G., Wu, S., Bao, X., et al. (2017) · Chemical Communications · doi:10.1039/c7cc01653k · Cited by 42 · see citing works

Enantioselective synthesis of spiro γ-butyrolactones by N-heterocyclic carbene (NHC)-catalyzed formal [3 + 2] annulation of enals with 3-hydroxy oxindoles

Mukherjee, S., Joseph, S., Bhunia, A., et al. (2017) · Organic & Biomolecular Chemistry · doi:10.1039/c7ob00148g · Cited by 41 · see citing works

Diastereo- and enantioselective construction of spirooxindole scaffolds through a catalytic asymmetric [3 + 3] cycloaddition

Li, C., Han, L., Sun, X., et al. (2017) · Organic & Biomolecular Chemistry · doi:10.1039/c7ob01059a · Cited by 41 · see citing works

Asymmetric Synthesis of Spirooxindole δ‐Lactones with Vicinal Tertiary and Quaternary Stereocenters via Regio‐, Diastereo‐, and Enantioselective Organocatalytic Vinylogous Aldol‐cyclization Cascade Reaction

Han, J., Tsai, Y. S., & Chang, C. (2017) · Advanced Synthesis & Catalysis · doi:10.1002/adsc.201701104 · Cited by 41 · see citing works

Magnesium( ii )-catalyzed asymmetric hetero-Diels–Alder reaction of Brassard's dienes with isatins

Zheng, J., Lin, L., Kuang, Y., et al. (2013) · Chemical Communications · doi:10.1039/c3cc47800a · Cited by 40 · see citing works

The First Enantioselective Organocatalytic Synthesis of 3‐Spiro‐α‐Alkylidene‐γ‐Butyrolactone Oxindoles

Cerisoli, L., Lombardo, M., Trombini, C., & Quintavalla, A. (2016) · Chemistry - A European Journal · doi:10.1002/chem.201504157 · Cited by 40 · see citing works

Organocatalytic construction of spirooxindole naphthoquinones through Michael/hemiketalization using l -proline derived bifunctional thiourea

Gajulapalli, V. P. R., Lokesh, K., Vishwanath, M., et al. (2016) · RSC Advances · doi:10.1039/c5ra25025k · Cited by 40 · see citing works

Highly diastereoselective entry into chiral spirooxindole-based 4-methyleneazetidines via formal [2+2] annulation reaction

Rainoldi, G., Faltracco, M., Presti, L. L., et al. (2016) · Chemical Communications · doi:10.1039/c6cc05838h · Cited by 40 · see citing works

Highly enantioselective synthesis of spirocyclopropyloxindoles via a Rh( ii )-catalyzed asymmetric cyclopropanation reaction

Chi, Y., Qiu, L., & Xu, X. (2016) · Organic & Biomolecular Chemistry · doi:10.1039/c6ob02160c · Cited by 40 · see citing works

Non‐Covalent Carbonyl‐Directed Heck–Matsuda Desymmetrizations: Synthesis of Cyclopentene‐Fused Spirooxindoles, Spirolactones, and Spirolactams

Kattela, S., Heerdt, G., & Correia, C. R. D. (2017) · Advanced Synthesis & Catalysis · doi:10.1002/adsc.201600946 · Cited by 40 · see citing works

Enantioselective assembly of functionalized carbocyclic spirooxindoles using an l -proline derived thiourea organocatalyst

Gajulapalli, V. P. R., Vinayagam, P., & Kesavan, V. (2014) · RSC Advances · doi:10.1039/c4ra13711f · Cited by 39 · see citing works

Quinine-catalyzed asymmetric domino Mannich-cyclization reactions of 3-isothiocyanato oxindoles with imines for the synthesis of spirocyclic oxindoles

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Catalytic Asymmetric Michael Addition/Cyclization Cascade Reaction of 3‐Isothiocyanatooxindoles with Nitro Olefins

Kayal, S., & Mukherjee, S. (2014) · European Journal of Organic Chemistry · doi:10.1002/ejoc.201402534 · Cited by 38 · see citing works

Trienamine catalysis with linear deconjugated 3,5-dienones

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Enantioselective [3+2] Cyclization of 3‐Isothiocyanato Oxindoles with Trifluoromethylated 2‐Butenedioic Acid Diesters

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Synthesis of Optically Pure Spiro[cyclohexane-oxindoline] Derivatives via Catalytic Asymmetric Diels–Alder Reaction of Brassard-Type Diene with Methyleneindolines

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