Cited by 43Nanoparticle-Based Drug DeliveryDendrimers and Hyperbranched PolymersAdvanced Polymer Synthesis and Characterization

Biodegradable polyester unimolecular systems as emerging materials for therapeutic applications

Liu, Xuan, Fan, Xiaoshan, Jiang, Lu, Loh, Xian Jun, Wu, Yun-Long, Li, Zibiao·2018·Journal of Materials Chemistry B

Abstract

Unimolecular micelles, as a class of single-molecular micelles, are structurally stable regardless of their concentrations or alterations of the outer environment such as pH, temperature, ion strength etc. in comparison with conventional polymeric micelles. Polyester unimolecular micelles are extensively applied in bio-medical fields because of their stability, biocompatibility, biodegradability, structural-controllabilty etc. In this review, the most recent developments in polyester unimolecular micelle designs in terms of Boltorn polymer H40 core, cyclodextrin, dendrimer or dendrimer-like polymer, or polyhedral oligomeric silsesquioxane (POSS) based polyester unimolecular micelles are presented. The significance and application in biomedical fields including drug delivery, bio-imaging and theranostics are also classified in this review. Finally, the remaining challenges and future perspectives for further development of unimolecular micelles as therapeutic materials are also discussed.

Integrity signals

Registry

Crossref · 10.1039/c8tb01883a

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126 of 126 references verified0 citation errors · 0 not checkable

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Authors
Liu, X., Fan, X., Jiang, L., Loh, X. J., Wu, Y.-L., & Li, Z.
Affiliations
  • Xiamen University (CN)
  • Henan Normal University (CN)
  • Agency for Science, Technology and Research (SG)
Corresponding author
  • Wu, Yun-Long
  • Li, Zibiao
Venue
Journal of Materials Chemistry B
Published
2018
Volume
6
Issue
35
Pages
5488-5498
ISSN
  • 2050-750X (ISSN-L)
  • 2050-7518
OpenAlex
W2886765558
Cited by
43
References
126
Citations by year
2026: 3 · 2025: 5 · 2024: 2 · 2023: 2 · 2022: 6 · 2021: 7 · 2020: 7 · 2019: 8 · 2018: 3
FWCI
2.02
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Materials Chemistry B (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Natural Science Foundation of China (81773661, 21303145)
  • Agency for Science, Technology and Research
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
  • Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
Keywords
unimolecular micelles, biodegradable polymers, polyhydroxyalkanoates, cyclodextrins, dendrimers, polyhedral oligomeric silsesquioxane, drug delivery, bioimaging, theranostics, biocompatibility

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