Biodegradable polyester unimolecular systems as emerging materials for therapeutic applications
Abstract
Unimolecular micelles, as a class of single-molecular micelles, are structurally stable regardless of their concentrations or alterations of the outer environment such as pH, temperature, ion strength etc. in comparison with conventional polymeric micelles. Polyester unimolecular micelles are extensively applied in bio-medical fields because of their stability, biocompatibility, biodegradability, structural-controllabilty etc. In this review, the most recent developments in polyester unimolecular micelle designs in terms of Boltorn polymer H40 core, cyclodextrin, dendrimer or dendrimer-like polymer, or polyhedral oligomeric silsesquioxane (POSS) based polyester unimolecular micelles are presented. The significance and application in biomedical fields including drug delivery, bio-imaging and theranostics are also classified in this review. Finally, the remaining challenges and future perspectives for further development of unimolecular micelles as therapeutic materials are also discussed.
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Limited drug loading capacity, insufficient stability, irritant excipients and incomplete drug discharge are inherent bottlenecks.
“Limited drug loading capacity, insufficient stability, irritant excipients and incomplete drug discharge are inherent bottlenecks.”
From From design to Deployment: The innovative role of nanomicelles in targeted ophthalmic therapeutics (2025) · cites this paper as [213]
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Li, Z., Liu, M., Ke, L., Wang, L.-J., Wu, C., Li, C., Li, Z., & Wu, Y.-L. (2021) · Nanoscale Advances · doi:10.1039/d1na00596k · Cited by 59 · see citing works
Self-citationFrom design to Deployment: The innovative role of nanomicelles in targeted ophthalmic therapeutics
Sun, M., Wang, J., Fan, W., Wang, K., Wang, Y., Zhang, J., Ding, S., Zhang, C., Feng, Z., Wang, Y.-G., et al. (2025) · Materials today. Bio · doi:10.1016/j.mtbio.2025.102537 · Cited by 7 · see citing works
“There are many other variable enigmas that could influence the release properties of polymer micelle [213].”
- Authors
- Liu, X., Fan, X., Jiang, L., Loh, X. J., Wu, Y.-L., & Li, Z.
- Affiliations
- Xiamen University (CN)
- Henan Normal University (CN)
- Agency for Science, Technology and Research (SG)
- Corresponding author
- Wu, Yun-Long
- Li, Zibiao
- Venue
- Journal of Materials Chemistry B
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2018
- Volume
- 6
- Issue
- 35
- Pages
- 5488-5498
- ISSN
- 2050-750X (ISSN-L)
- 2050-7518
- OpenAlex
- W2886765558
- Cited by
- 43
- References
- 126
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 2 · 2023: 2 · 2022: 6 · 2021: 7 · 2020: 7 · 2019: 8 · 2018: 3
- FWCI
- 2.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Materials Chemistry B (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81773661, 21303145)
- Agency for Science, Technology and Research
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
- Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
- Keywords
- unimolecular micelles, biodegradable polymers, polyhydroxyalkanoates, cyclodextrins, dendrimers, polyhedral oligomeric silsesquioxane, drug delivery, bioimaging, theranostics, biocompatibility
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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