Copper-nanoparticle-embedded hydrogel for killing bacteria and promoting wound healing with photothermal therapy
Abstract
could stimulate NIH-3T3 fibroblast proliferation without any inflammatory responses. Moreover, chronic wound healing process of S. aureus-infected model was significantly accelerated with prominent antibacterial ability, reduced inflammatory response, and promoted angiogenesis ability in vivo. In summary, Cu-NP-embedded hydrogels are a promising candidate for skin tissue regeneration and potentially valuable for clinical applications.
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Copper-containing biomaterials promote healing of infected wounds, including MRSA and Escherichia coli biofilm.
“Additionally, copper-containing biomaterials, mostly wound dressings, have shown significant potential in promoting the healing of infected wounds [68,87,91,92,93,94,95,96,97,98], including those infected with MRSA [99] and Escherichia coli biofilm [100].”
From The Journey of Copper-Impregnated Dressings in Wound Healing: From a Medical Hypothesis to Clinical Practice (2025) · cites this paper as [95]
Cites
Dermal adipocytes protect against invasive <i>Staphylococcus aureus</i> skin infection
Zhang, L.-J., Guerrero-Juarez, C. F., Hata, T., Bapat, S. P., Ramos, R., Plikus, M. V., & Gallo, R. L. (2015) · Science · doi:10.1126/science.1260972 · Cited by 471 · see citing works
Polysaccharide matrices used in 3D in vitro cell culture systems
Diekjürgen, D., & Grainger, D. W. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.06.020 · Cited by 125 · see citing works
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Hydrogels and Nanogels: Pioneering the Future of Advanced Drug Delivery Systems
Delgado-Pujol, E. J., Martínez, G., Casado-Jurado, D., Vázquez, J., León-Barberena, J., Rodríguez-Lucena, D., Torres, Y., Alcudia, A., & Begines, B. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17020215 · Cited by 216 · see citing works
Borkow, G., & Melamed, E. (2025) · Biomedicines · doi:10.3390/biomedicines13030562 · Cited by 24 · see citing works
- Authors
- Tao, B., Lin, C., Deng, Y., Yuan, Z., Shen, X., Chen, M., He, Y., Peng, Z., Hu, Y., & Cai, K.
- Affiliations
- Chongqing University (CN)
- Key Laboratory of Biorheological Science and Technology of Ministry of Education
- Army Medical University (CN)
- Corresponding author
- Cai, Kaiyong
- Venue
- Journal of Materials Chemistry B
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2019
- Volume
- 7
- Issue
- 15
- Pages
- 2534-2548
- ISSN
- 2050-750X (ISSN-L)
- 2050-7518
- OpenAlex
- W2920422080
- Cited by
- 290
- References
- 2
- Citations by year
- 2026: 21 · 2025: 36 · 2024: 55 · 2023: 37 · 2022: 61 · 2021: 38 · 2020: 32 · 2019: 10
- FWCI
- 24.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Materials Chemistry B (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (51303218, 51673032, 21734002)
- Natural Science Foundation of Chongqing (CSTC2014jcyjA10008)
- Topics
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Keywords
- copper nanoparticles, hydrogels, photothermal therapy, antibacterial activity, wound healing, chronic wounds, Staphylococcus aureus, angiogenesis, fibroblast proliferation, skin regeneration, inflammation
- MeSH terms
- Animals, Anti-Bacterial Agents, Cell Survival, Copper, Escherichia coli, Phototherapy, Staphylococcus aureus, Wound Healing, Lipid Peroxidation, Hydrogels, NIH 3T3 Cells, Mice, Metal Nanoparticles
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