An osteoconductive PLGA scaffold with bioactive β-TCP and anti-inflammatory Mg(OH) 2 to improve in vivo bone regeneration
Abstract
Poly(lactic- co -glycolic acid) (PLGA) has been widely used as a biomaterial for pharmaceutical and medical applications.
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The presence of inflammatory degradation products makes it difficult to meet clinical use needs.
“the presence of inflammatory degradation products [9,10]”
From A strategy to tailor the mechanical and degradation properties of PCL-PEG-PCL based copolymers for biomedical application (2023) · cites this paper as [9]
Cites
An Overview of Poly(lactic-co-glycolic) Acid (PLGA)-Based Biomaterials for Bone Tissue Engineering
Gentile, P., Chiono, V., Carmagnola, I., & Hatton, P. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15033640 · Cited by 1,593 · see citing works
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Santos-Rosales, V., Magariños, B., Starbird, R., Suárez-González, J., Fariña, J. B., Alvarez-Lorenzo, C., & García-González, C. A. (2021) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2021.120801 · Cited by 32 · see citing works
Liu, Y.-Y., Blázquez, J. P. F., Yin, G.-Z., Wang, D.-Y., Llorca, J., & Echeverry-Rendón, M. (2023) · arXiv · doi:10.48550/arxiv.2308.15503 · Cited by 46 · see citing works
“However, the mismatch of mechanical properties and degradation rate [7,8], the presence of inflammatory degradation products [9,10], and difficulties to manufacture personalized scaffolds with precise pore interconnections [11,12] make it difficult to meet clinical use needs.”
Background
- Authors
- Go, E. J., Kang, E. Y., Lee, S. K., Park, S., Kim, J. H., Park, W., Kim, I. H., Choi, B., & Han, D. K.
- Affiliations
- CHA University (KR)
- Korea University (KR)
- Department of Orthopaedic Surgery
- CHA University Bundang Medical Center (KR)
- Corresponding author
- Kim, Ik Hwan
- Choi, Bogyu
- Han, Dong Keun
- Venue
- Biomaterials Science
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2020
- Volume
- 8
- Issue
- 3
- Pages
- 937-948
- ISSN
- 2047-4830 (ISSN-L)
- 2047-4849
- OpenAlex
- W2992188305
- Cited by
- 85
- References
- 1
- Citations by year
- 2026: 7 · 2025: 14 · 2024: 13 · 2023: 14 · 2022: 18 · 2021: 15 · 2020: 4
- FWCI
- 3.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biomaterials Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Research Foundation of Korea (2017R1A2B3011121, 2018M3A9E2024579)
- Korea Health Industry Development Institute (HI18C0089)
- Ministry of Trade, Industry and Energy (10048019)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Physical Sciences › Materials Science › Biomaterials › Magnesium Alloys: Properties and Applications
- Keywords
- PLGA, beta-tricalcium phosphate, magnesium hydroxide, bone regeneration, osteoconduction, osteoinduction, anti-inflammatory response, bone defect repair, osteoblasts, orthopedic implants, bulk modification, twin-screw extrusion
- MeSH terms
- Animals, Anti-Inflammatory Agents, Biocompatible Materials, Bone Regeneration, Calcium Phosphates, Cell Differentiation, Female, Humans, Humerus, Magnesium Hydroxide, Osteoblasts, Osteogenesis, Polyglycolic Acid, Rats, Sprague-Dawley, Prostheses and Implants, Tissue Engineering, Rats, Nanocomposites, Tissue Scaffolds
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