Sgc8 aptamer targeted glutathione-responsive nanoassemblies containing Ara-C prodrug for the treatment of acute lymphoblastic leukemia
Abstract
Cytarabine (Ara-C) is an essential medicine used in the clinical treatment of acute lymphoblastic leukemia.
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Sgc8-modified DNA nanostructures loading methylene blue show specificity and high uptake in CEM cells, inducing stronger antitumor activity in PDT.
“Jin et al. used Sgc8 aptamers to modify biocompatible DNA nanostructures to load the photosensitizer methylene blue.260 CEM cells show specificity and high uptake of aptamer modified drug delivery system, which can induce stronger antitumor activity in photodynamic therapy.”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [260]
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References 35 · Cited by 33
- Authors
- Fang, Z., Wang, X., Sun, Y., Fan, R., Liu, Z., Guo, R., & Xie, D.
- Affiliations
- Third Affiliated Hospital of Sun Yat-sen University (CN)
- Jinan University (CN)
- Corresponding author
- Liu, Zhong
- Guo, Rui
- Xie, Deming
- Venue
- Nanoscale
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2019
- Volume
- 11
- Issue
- 47
- Pages
- 23000-23012
- ISSN
- 2040-3364 (ISSN-L)
- 2040-3372
- OpenAlex
- W2983147269
- Cited by
- 33
- References
- 35
- Citations by year
- 2025: 5 · 2024: 5 · 2023: 10 · 2022: 4 · 2021: 6 · 2020: 3
- FWCI
- 0.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nanoscale (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Guangzhou Municipal Science and Technology Project (201508020115, 201601010270, 2017010160489, 201704030083, 201907010032, 201907010037)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- glutathione-responsive release, polymeric micelles, acute lymphoblastic leukemia, targeted drug delivery, bovine serum albumin, CCRF-CEM cells, tumor xenografts, hemocompatibility
- MeSH terms
- Animals, Antineoplastic Agents, Biocompatible Materials, Cytarabine, Glutathione, Hemolysis, Humans, Mice, Nude, Micelles, Neoplasm Transplantation, Particle Size, Polyesters, Serum Albumin, Bovine, Drug Delivery Systems, Apoptosis, Cell Line, Tumor, Mice, Precursor Cell Lymphoblastic Leukemia-Lymphoma, MCF-7 Cells
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