Novel polymeric micelles as enzyme-sensitive nuclear-targeted dual-functional drug delivery vehicles for enhanced 9-nitro-20( S )-camptothecin delivery and antitumor efficacy
Abstract
Antitumor drug 9-NC was loaded in the HA based micelles 9-NC/HATPC, which were targeted to tumor and dissociated into secondary micelles 9-NC/TPC in lysosomes in tumor cells and then it could delivery 9-NC directly to the cell “heart”.
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Ebrahim Attia et al. measured the size of doxorubicin-loaded PEG micelles in 10% fetal bovine serum solution over 48 hours to exclude possible precipitation or aggregation at physiological conditions, confirming micelles stability.
“With regard to more biorelevant media, Ebrahim Attia et al. [139], measured the size of doxorubicin-loaded poly(ethylene glycol) (PEG) micelles in 10% fetal bovine serum (FBS) solution over 48 hours to exclude possible precipitation or aggregation at physiological conditions, confirming micelles stability.”
From Polymeric micelles in drug delivery: An insight of the techniques for their characterization and assessment in biorelevant conditions (2021) · cites this paper as [139]
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Ghezzi, M., Pescina, S., Padula, C., Santi, P., Del Favero, E., Cantù, L., & Nicoli, S. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.02.031 · Cited by 1,135 · see citing works
Joy, R., George, J., & John, F. (2022) · ChemistrySelect · doi:10.1002/slct.202104045 · Cited by 50 · see citing works
- Authors
- Sun, Y., Liang, Y., Hao, N., Fu, X., He, B., Han, S., Cao, J., Ma, Q., Xu, W., & Sun, Y.
- Affiliations
- Qingdao University (CN)
- Southwest Medical University (CN)
- People's Liberation Army 401 Hospital (CN)
- Sichuan University (CN)
- Affiliated Hospital of Qingdao University (CN)
- Corresponding author
- Sun, Yong
- Venue
- Nanoscale
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2020
- Volume
- 12
- Issue
- 9
- Pages
- 5380-5396
- ISSN
- 2040-3364 (ISSN-L)
- 2040-3372
- OpenAlex
- W3002496002
- Cited by
- 60
- References
- 0
- Citations by year
- 2026: 8 · 2025: 4 · 2024: 4 · 2023: 8 · 2022: 14 · 2021: 17 · 2020: 5
- FWCI
- 2.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nanoscale (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (51803098, 81673360)
- Natural Science Foundation of Shandong Province (ZR2018BEM032, ZR2017BC012)
- China Postdoctoral Science Foundation (2017M622134)
- Qingdao University (41117010022)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
- Keywords
- polymeric micelles, nuclear targeting, chrysin, polycaprolactone, hyaluronic acid, TAT peptide, cathepsin B, lysosomal escape, CD44 receptor, antitumor efficacy, SKOV3 cells
- MeSH terms
- Animals, Antineoplastic Agents, Phytogenic, Camptothecin, Cell Nucleus, Cell Survival, Drug Carriers, Humans, Mice, Nude, Micelles, Neoplasms, Particle Size, Peptides, Polymers, Transplantation, Heterologous, Apoptosis, Cell Line, Tumor, Mice
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