Cited by 50Nanoparticle-Based Drug DeliveryAdvanced Drug Delivery SystemsHydrogels: synthesis, properties, applications

Brief Outlook on Polymeric Nanoparticles, Micelles, Niosomes, Hydrogels and Liposomes: Preparative Methods and Action

Joy, Reshma, George, Jinu, John, Franklin·2022·ChemistrySelect

Abstract

Polymeric nanoparticles, micelles, niosomes, hydrogels and liposomes represent effective drug carriers having huge potential for medical and pharmaceutical applications. These systems remain the most important area in medicinal chemistry research. The aforementioned biomaterials can effectively encapsulate and release diverse hydrophobic/hydrophilic therapeutic molecules including drugs and prodrugs. Applications of these carrier systems extend to nucleic acids, antibodies and proteins which could be released sustainably. Since these systems fall in the nano dimension, they are capable of enhancing the therapeutic efficacy of bioactive molecules besides enabling them to accumulate preferentially at the target site. Furthermore, these systems can protect the encapsulated drug from degradation, thereby increasing the therapeutic value of the drug candidate and reducing systemic toxicity. In this review, we illustrate the preparative methods and actions of these five drug delivery systems.

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Crossref · 10.1002/slct.202104045

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152 of 152 references verified0 citation errors · 0 not checkable

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  • Micelles are suitable for the delivery of water-insoluble and amphiphilic drugs.

    “For example, micelles are suitable for the delivery of water-insoluble and amphiphilic drugs, and liposomes can increase the cellular uptake of a variety of drugs.14,15”

    From Smart nanoparticles for cancer therapy (2023) · cites this paper as [14]

  • Liposomes can increase the cellular uptake of a variety of drugs.

    “For example, micelles are suitable for the delivery of water-insoluble and amphiphilic drugs, and liposomes can increase the cellular uptake of a variety of drugs.14,15”

    From Smart nanoparticles for cancer therapy (2023) · cites this paper as [14]

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Authors
Joy, R., George, J., & John, F.
Affiliations
Sacred Heart College (IN)
Corresponding author
  • George, Jinu
  • John, Franklin
Venue
ChemistrySelect
Publisher
Wiley
Published
2022-02-08
Volume
7
Issue
6
ISSN
2365-6549 (ISSN-L)
OpenAlex
W4210903779
Cited by
50
References
152
Citations by year
2026: 6 · 2025: 18 · 2024: 8 · 2023: 15 · 2022: 3
FWCI
2.75
Type
journal article
Language
en
Open access
closed
Locations
ChemistrySelect (publishedVersion)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
Keywords
polymeric nanoparticles, micelles, niosomes, hydrogels, liposomes, drug delivery systems, drug carriers, drug encapsulation, controlled drug release, prodrugs, nucleic acid delivery, targeted drug delivery, drug protection from degradation, systemic toxicity reduction

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