The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Peptide nucleic acid (PNA). A DNA mimic with a pseudopeptide backbone
Abstract
PNA (peptide nucleic acid) is a DNA mimic with a pseudopeptide backbone composed of N-(2-aminoethyl)glycine units with the nucleobases attached to the glycine nitrogen via carbonyl methylene linkers. PNA was first described in 1991 and has since then attracted broad attention within the fields of bioorganic chemistry, medicinal chemistry, physical chemistry and molecular biology due to its chemical and physical properties, in particular with regard to efficient and sequence specific binding to both single stranded RNA and DNA as well as to double stranded DNA. The present review discusses the structural features that provide the DNA mimicking properties of PNA and gives an overview of structural backbone modifications of PNA.
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Citations
Cites
A Production of Amino Acids Under Possible Primitive Earth Conditions
Miller, S. L. (1953) · Science · doi:10.1126/science.117.3046.528 · Cited by 3,522
Sequence-Selective Recognition of DNA by Strand Displacement with a Thymine-Substituted Polyamide
Nielsen, P. E., Egholm, M., Berg, R. H., & Buchardt, O. (1991) · Science · doi:10.1126/science.1962210 · Cited by 3,332
Self-citationPNA hybridizes to complementary oligonucleotides obeying the Watson–Crick hydrogen-bonding rules
Egholm, M., Buchardt, O., Christensen, L., Behrens, C., Freier, S. M., Driver, D. A., Berg, R. H., Kim, S. K., Norden, B., & Nielsen, P. E. (1993) · Nature · doi:10.1038/365566a0 · Cited by 2,079
Self-citation
Cited by
Synthetic Molecular Motors and Mechanical Machines
Kay, E. R., Leigh, D. A., & Zerbetto, F. (2007) · Angewandte Chemie International Edition · doi:10.1002/anie.200504313 · Cited by 2,609
Koshkin, A. A., Singh, S. K., Nielsen, P., Rajwanshi, V. K., Kumar, R., Meldgaard, M., Olsen, C. E., & Wengel, J. (1998) · Tetrahedron · doi:10.1016/s0040-4020(98)00094-5 · Cited by 1,047
Self-citationPhotocleavage of Nucleic Acids
Armitage, B. (1998) · Chemical Reviews · doi:10.1021/cr960428+ · Cited by 688
Synthetische molekulare Motoren und mechanische Maschinen
Kay, E. R., Leigh, D. A., & Zerbetto, F. (2007) · Angewandte Chemie · doi:10.1002/ange.200504313 · Cited by 624
Impedance-based detection of DNA sequences using a silicon transducer with PNA as the probe layer
Macanovic, A. (2004) · Nucleic Acids Research · doi:10.1093/nar/gnh003 · Cited by 309
Metadata
- Authors
- Nielsen, P. E., & Haaima, G.
- Venue
- Chemical Society Reviews
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 1997
- Volume
- 26
- Issue
- 2
- Pages
- 73
- ISSN
- 0306-0012 (ISSN-L)
- 1460-4744
- OpenAlex
- W2059615369
- Cited by
- 223
- References
- 3
- FWCI
- 5.06
- Type
- journal article
- Language
- en
- Open access
- closed
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- Nielsen, P. E., & Haaima, G. (1997). Peptide nucleic acid (PNA). A DNA mimic with a pseudopeptide backbone. Chemical Society Reviews. https://doi.org/10.1039/cs9972600073
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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