Recent advances in nanomaterial-based augmented sonodynamic therapy of cancer
Abstract
This review focuses on recent advances in augmented sonodynamic therapy (SDT) using engineered nanomaterials, and the mechanism of SDT for discussing future perspectives.
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Released energy can cause pyrolysis of nearby water to produce hydroxyl radicals.
“In addition, the released energy can also cause a pyrolysis reaction of the nearby water (H2O) to produce hydroxyl radicals (·OH) [21, 38].”
From Nanosensitizer-assisted sonodynamic therapy for breast cancer (2025) · cites this paper as [38]
Excited sonosensitizers release energy to oxygen, causing formation of reactive oxygen species such as superoxide anions and singlet oxygen.
“When the excited sonosensitizers return to the ground state, they can release energy to oxygen (O2), causing the formation of ROS, such as superoxide anions (·O2−) and singlet oxygen (1O2).”
From Nanosensitizer-assisted sonodynamic therapy for breast cancer (2025) · cites this paper as [38]
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Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
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Catalase-Integrated Hyaluronic Acid as Nanocarriers for Enhanced Photodynamic Therapy in Solid Tumor
Phua, S. Z. F., Yang, G., Lim, W. Q., Verma, A., Chen, H., Thanabalu, T., & Zhao, Y. (2019) · ACS Nano · doi:10.1021/acsnano.9b01087 · Cited by 375 · see citing works
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Defect modified zinc oxide with augmenting sonodynamic reactive oxygen species generation
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Sonodynamic Therapy: Advances and Challenges in Clinical Translation
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Low frequency nanobubble-enhanced ultrasound mechanotherapy for noninvasive cancer surgery
Bismuth, M., Katz, S., Mano, T., Aronovich, R., Hershkovitz, D., Exner, A. A., & Ilovitsh, T. (2022) · Nanoscale · doi:10.1039/d2nr01367c · Cited by 40 · see citing works
Nanosensitizer-assisted sonodynamic therapy for breast cancer
Yu, J., Hu, J.-R., Tian, Y., Lei, Y.-M., Hu, H.-M., Lei, B.-S., Zhang, G., Sun, Y., & Ye, H.-R. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03311-3 · Cited by 43 · see citing works
- Authors
- Um, W., E. K., P. K., Lee, J., Kim, C. H., You, D. G., & Park, J. H.
- Affiliations
- Sungkyunkwan University (KR)
- School of Chemical Engineering
- Corresponding author
- Park, Jae Hyung
- Venue
- Chemical Communications
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2021
- Volume
- 57
- Issue
- 23
- Pages
- 2854-2866
- ISSN
- 1359-7345 (ISSN-L)
- 1364-548X
- OpenAlex
- W3132527780
- Cited by
- 120
- References
- 5
- Citations by year
- 2026: 14 · 2025: 25 · 2024: 22 · 2023: 25 · 2022: 23 · 2021: 11
- FWCI
- 1.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Chemical Communications (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Research Foundation of Korea (2016H1D3A1909300, 2018R1A2B3006080, 2018R1D1A1B07050867, 2020R1A6A3A01100335)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Radiation Therapy and Dosimetry
- Keywords
- sonodynamic therapy, sonosensitizer, nanomaterials, reactive oxygen species generation, oxidative stress, antitumor immunity, cancer therapy, non-invasive cancer treatment
- MeSH terms
- Drug Development, Animals, Antineoplastic Agents, Combined Modality Therapy, Humans, Immunotherapy, Models, Biological, Neoplasms, Ultrasonic Therapy, Reactive Oxygen Species, Oxidative Stress, Nanostructures
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