Molecular photoswitches in aqueous environments

Significance of the Protein Interface Configuration for Allostery in Imidazole Glycerol Phosphate Synthase

Kneuttinger, A. C., Rajendran, C., Simeth, N. A., Bruckmann, A., König, B., & Sterner, R. (2020) · Biochemistry · doi:10.1021/acs.biochem.0c00332 · Cited by 30

The effect of azobenzene cross-linker position on the degree of helical peptide photo-control

Ali, A. M., & Woolley, G. A. (2013) · Organic & Biomolecular Chemistry · doi:10.1039/c3ob40684a · Cited by 29

Zinc(II)-Regulation of Hydrazone Switch Isomerization Kinetics

Su, X., & Aprahamian, I. (2013) · Organic Letters · doi:10.1021/ol402789y · Cited by 29

Computational Design of a Photocontrolled Cytosine Deaminase

Blacklock, K. M., Yachnin, B. J., Woolley, G. A., & Khare, S. D. (2017) · Journal of the American Chemical Society · doi:10.1021/jacs.7b08709 · Cited by 29

A Prospective Ultrafast Hemithioindigo Molecular Motor

Schildhauer, M., Rott, F., Thumser, S., Mayer, P., de Vivie‐Riedle, R., & Dube, H. (2019) · ChemPhotoChem · doi:10.1002/cptc.201900074 · Cited by 29

Regulation of mRNA translation by a photoriboswitch

Rotstan, K. A., Abdelsayed, M. M., Passalacqua, L. F. M., Chizzolini, F., Sudarshan, K., Chamberlin, A. R., Míšek, J., & Lupták, A. (2020) · eLife · doi:10.7554/elife.51737 · Cited by 29

Putting Photomechanical Switches to Work: An Ab Initio Multiple Spawning Study of Donor–Acceptor Stenhouse Adducts

Sanchez, D. M., Raucci, U., Ferreras, K. N., & Martı́nez, T. J. (2020) · The Journal of Physical Chemistry Letters · doi:10.1021/acs.jpclett.0c02401 · Cited by 29

Spatio-temporal control of cellular uptake achieved by photoswitchable cell-penetrating peptides

Prestel, A., & Möller, H. M. (2015) · Chemical Communications · doi:10.1039/c5cc06848g · Cited by 27

Highly Cooperative Photoswitching in Dihydropyrene Dimers

Liesfeld, P., Garmshausen, Y., Budzák, Š., Becker, J., Dallmann, A., Jacquemin, D., & Hecht, S. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202008523 · Cited by 27

“Flexible-Acceptor” General Solubility Equation for beyond Rule of 5 Drugs

Avdeef, A., & Kansy, M. (2020) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.0c00689 · Cited by 27

Site-Specific Labeling of Protein Lysine Residues and N-Terminal Amino Groups with Indoles and Indole-Derivatives

Larda, S. T., Pichugin, D., & Prosser, R. S. (2015) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.5b00457 · Cited by 26

A Photoswitchable Inhibitor of the Human Serotonin Transporter

Cheng, B., Morstein, J., Ladefoged, L. K., Maesen, J. B., Schiøtt, B., Sinning, S., & Trauner, D. H. (2020) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.9b00521 · Cited by 26

Optimizing the Photocontrol of bZIP Coiled Coils with Azobenzene Crosslinkers: Role of the Crosslinking Site

Ali, A. M., Forbes, M. W., & Woolley, G. A. (2015) · ChemBioChem · doi:10.1002/cbic.201500191 · Cited by 25

Stiff-stilbene derivatives as new bright fluorophores with aggregation-induced emission

Wu, Y., Huang, K., Chen, S., et al. (2019) · Science China Chemistry · doi:10.1007/s11426-019-9514-8 · Cited by 25

Synthesis, Derivatization and Photochemical Control of ortho‐Functionalized Tetrachlorinated Azobenzene‐Modified siRNAs

Hammill, M. L., Islam, G., & Desaulniers, J. (2020) · ChemBioChem · doi:10.1002/cbic.202000188 · Cited by 25

Reductive stability evaluation of 6-azopurine photoswitches for the regulation of CKIα activity and circadian rhythms

Kolarski, D., Sugiyama, A., Rodat, T., Schulte, A. M., Peifer, C., Itami, K., Hirota, T., Feringa, B. L., & Szymański, W. (2021) · Organic & Biomolecular Chemistry · doi:10.1039/d1ob00014d · Cited by 25

Engineered Catalytic RNA and DNA

Steele, D., Kertsburg, A., & Soukup, G. A. (2003) · American Journal of PharmacoGenomics · doi:10.2165/00129785-200303020-00006 · Cited by 24

Recent advances on small‐molecule nanomedicines for cancer treatment

Xue, X., Lindstrom, A. R., Qu, H., & Li, Y. (2019) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1607 · Cited by 24

Design of a Photoswitchable Cadherin

Ritterson, R. S., Kuchenbecker, K. M., Michalik, M., & Kortemme, T. (2013) · Journal of the American Chemical Society · doi:10.1021/ja404992r · Cited by 23

Reversible Heterochiral Aggregation/Dissociation of Bis(2‐hydroxyphenyl)diamides Driven by UV/Vis Irradiation

Nojiri, A., Kumagai, N., & Shibasaki, M. (2012) · Angewandte Chemie International Edition · doi:10.1002/anie.201106832 · Cited by 23

Synthesis of Photochromic Compounds for Aqueous Solutions and Focusable Light

Polyakova, S. M., Belov, V. N., Bossi, M. L., & Hell, S. W. (2011) · European Journal of Organic Chemistry · doi:10.1002/ejoc.201100166 · Cited by 23

Solvent effects on the thermal isomerization of a rotary molecular motor

Lubbe, A. S., Kistemaker, J. C. M., Smits, E. J., & Feringa, B. L. (2016) · Physical Chemistry Chemical Physics · doi:10.1039/c6cp03571j · Cited by 23

Photopharmacologic Vision Restoration Reduces Pathological Rhythmic Field Potentials in Blind Mouse Retina

Hüll, K., Benster, T., Manookin, M. B., Trauner, D. H., Gelder, R. N. V., & Laprell, L. (2019) · Scientific Reports · doi:10.1038/s41598-019-49999-w · Cited by 23

Diarylethene moiety as an enthalpy-entropy switch: photoisomerizable stapled peptides for modulating p53/MDM2 interaction

Strizhak, A. V., Babii, O., Afonin, S., Bakanovich, I., Panteļejevs, T., Xu, W., Fowler, E., Eapen, R., Sharma, K., Platonov, M. O., et al. (2020) · Organic & Biomolecular Chemistry · doi:10.1039/d0ob00831a · Cited by 23

Conformational Switching of G‐Quadruplex DNA by Photoregulation

Wang, X., Huang, J., Zhou, Y., Yan, S., Weng, X., Wu, X., Deng, M., & Zhou, X. (2010) · Angewandte Chemie · doi:10.1002/ange.201002290 · Cited by 23

Loading of Vesicles into Soft Amphiphilic Nanotubes using Osmosis

Erne, P. M., van Bezouwen, L. S., Štacko, P., van Dijken, D. J., Chen, J., Stuart, M. C. A., Boekema, E. J., & Feringa, B. L. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201506493 · Cited by 21

Photochromic peptidic NPY Y 4 receptor ligands

Lachmann, D., Konieczny, A., Keller, M., & König, B. (2019) · Organic & Biomolecular Chemistry · doi:10.1039/c8ob03221a · Cited by 21

Optical Control of GABA A Receptors with a Fulgimide‐Based Potentiator

Rustler, K., Maleeva, G., Gomila, A. M. J., Gorostiza, P., Bregestovski, P. D., & König, B. (2020) · Chemistry - A European Journal · doi:10.1002/chem.202000710 · Cited by 21

Photoisomerizable arylstilbazolium ligands recognize parallel and antiparallel structures of G-quadruplexes

Czerwińska, I., & Juskowiak, B. (2012) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2012.06.027 · Cited by 20

Reversible Spatial Control in Aqueous Media by Visible Light: A Thioindigo Photoswitch that is Soluble and Operates Efficiently in Water

Koeppe, B., & Römpp, F. (2018) · Chemistry - A European Journal · doi:10.1002/chem.201803675 · Cited by 20

Towards Photochromic Azobenzene‐Based Inhibitors for Tryptophan Synthase

Simeth, N. A., Kinateder, T., Rajendran, C., Nazet, J., Merkl, R., Sterner, R., König, B., & Kneuttinger, A. C. (2020) · Chemistry - A European Journal · doi:10.1002/chem.202004061 · Cited by 20

Light-controlled out-of-equilibrium assembly of cyclodextrins in an enzyme-mediated dynamic system

Larsen, D., Bjerre, P. M., & Beeren, S. R. (2019) · Chemical Communications · doi:10.1039/c9cc08452e · Cited by 19

Photoswitchable Affinity Reagents: Computational Design and Efficient Red‐Light Switching

Yasuike, N., Blacklock, K. M., Lu, H., Jaikaran, A. S. I., McDonald, S., Uppalapati, M., Khare, S. D., & Woolley, G. A. (2019) · ChemPhotoChem · doi:10.1002/cptc.201900016 · Cited by 17

Synthesis and characterization of bis(4-amino-2-bromo-6-methoxy)azobenzene derivatives

Martínez‐López, D., Babalhavaeji, A., Sampedro, D., & Woolley, G. A. (2019) · Beilstein Journal of Organic Chemistry · doi:10.3762/bjoc.15.296 · Cited by 17

The effect of the formyl group position upon asymmetric isomeric diarylethenes bearing a naphthalene moiety

Wang, R., Pu, S., Liu, G., & Cui, S. (2012) · Beilstein Journal of Organic Chemistry · doi:10.3762/bjoc.8.114 · Cited by 16

Red-Purple Photochromic Indigos from Green Chemistry: Mono-tBOC or Di-tBOC N-Substituted Indigos Displaying Excited State Proton Transfer or Photoisomerization

Pinheiro, D., Galvão, A. M., Piñeiro, M., & de Melo, J. S. S. (2021) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.1c00120 · Cited by 16

BH3 helix-derived biophotonic nanoswitches regulate cytochrome c release in permeabilised cells

Mart, R. J., Errington, R. J., Watkins, C. L., Chappell, S. C., Wiltshire, M., Jones, A. T., Smith, P. J., & Allemann, R. K. (2013) · Molecular BioSystems · doi:10.1039/c3mb70246d · Cited by 15

Self-assembly of photoswitchable diblock copolymers: salt-induced micellization and the influence of UV irradiation

Zhang, J., Zhang, Y., Chen, F., Zhang, W., & Zhao, H. (2015) · Physical Chemistry Chemical Physics · doi:10.1039/c5cp01560j · Cited by 15

Improvement in Aqueous Solubility of Retinoic Acid Receptor (RAR) Agonists by Bending the Molecular Structure

Hiramatsu, M., Ichikawa, Y., Tomoshige, S., Makishima, M., Muranaka, A., Uchiyama, M., Yamaguchi, T., Hashimoto, Y., & Ishikawa, M. (2016) · Chemistry - An Asian Journal · doi:10.1002/asia.201600744 · Cited by 13

Fluorescence switching with subphthalocyanine-dihydroazulene dyads

Gotfredsen, H., Kilde, M. D., Santella, M., Kadziola, A., & Nielsen, M. B. (2019) · Molecular Systems Design & Engineering · doi:10.1039/c8me00075a · Cited by 13

Design and biological evaluation of photo-switchable inhibitors.

Füllbeck, M., Michalsky, E., Jaeger, I. S., Henklein, P., Kühn, H., Rück‐Braun, K., & Preißner, R. (2006) · PubMed · Cited by 12

Metal-binding hydrazone photoswitches for visible light reactivity and variable relaxation kinetics

Hall, K. C., Franks, A. T., McAtee, R. C., Wang, M. S., Lu, V. I., & Franz, K. J. (2017) · Photochemical & Photobiological Sciences · doi:10.1039/c7pp00173h · Cited by 11

Controlling the Uptake of Diarylethene‐Based Cell‐Penetrating Peptides into Cells Using Light

Schober, T., Wehl, I., Afonin, S., Babii, O., Iampolska, A. D., Schepers, U., Komarov, I. V., & Ulrich, A. S. (2019) · ChemPhotoChem · doi:10.1002/cptc.201900019 · Cited by 11

Activation of Sirtuin 2 Inhibitors Employing Photoswitchable Geometry and Aqueous Solubility

Grathwol, C. W., Wössner, N., Behnisch‐Cornwell, S., Schulig, L., Zhang, L., Einsle, O., Jung, M., & Link, A. (2020) · ChemMedChem · doi:10.1002/cmdc.202000148 · Cited by 10

End-capping of amphiphilic nanotubes with phospholipid vesicles: impact of the phospholipid on the cap formation and vesicle loading under osmotic conditions

Erne, P. M., Štacko, P., van Dijken, D. J., Chen, J., Stuart, M. C. A., & Feringa, B. L. (2016) · Chemical Communications · doi:10.1039/c6cc05101d · Cited by 9

Water, the Universal Solvent for Life

Reichardt, K., & Timm, L. C. (2019) · Springer eBooks · doi:10.1007/978-3-030-19322-5_2 · Cited by 7

Visible-light-driven photocontrol of the Trp-cage protein fold by a diazocine cross-linker.

Preußke, N., Moormann, W., Bamberg, K., Lipfert, M., Herges, R., & Sönnichsen, F. (2020) · Organic and biomolecular chemistry · doi:10.1039/c9ob02442e · Cited by 6

Controlling Hydrogel Properties by the Cooperative Harvesting of the Components of Sunlight

Kou, R., Wang, T., Chen, Z., Zhu, R., Cai, H., Pang, H., Xuan, S., & Liu, G. (2019) · Langmuir · doi:10.1021/acs.langmuir.9b02244 · Cited by 5

A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective ligation of azides and terminal alkynes

Rostovtsev, V. V., Green, L. G., Fokin, V. V., & Sharpless, K. B. (2002) · Angewandte Chemie International Edition · doi:10.1002/1521-3773(20020715)41:14<2596::aid-anie2596>3.0.co;2-4

Visible‐ and Near‐Infrared Light‐Driven Molecular Photoswitches for Biological Applications

Xu, Y., Tang, Y., & Li, Q. (2025) · Advanced Functional Materials · doi:10.1002/adfm.202416359 · Cited by 49

Expanding the Repertoire of Photoswitchable Unnatural Amino Acids for Enzyme Engineering

Hiefinger, C., Marcon, M., Pape, V., Casadevall, G., Lahmy, R., Haag, C., Nazet, J., Bartl, M., Bruckmann, A., Osuna, S., et al. (2025) · Angewandte Chemie International Edition · doi:10.1002/anie.202508562 · Cited by 5

Expanding the Repertoire of Photoswitchable Unnatural Amino Acids for Enzyme Engineering

Hiefinger, C., Marcon, M., Pape, V., Casadevall, G., Lahmy, R., Nazet, J., Bartl, M., Bruckmann, A., Osuna, S., König, B., et al. (2025) · doi:10.1101/2025.04.17.649278 · Cited by 2