Molecular photoswitches in aqueous environments

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings 1PII of original article: S0169-409X(96)00423-1. The article was originally published in Advanced Drug Delivery Reviews 23 (1997) 3–25. 1

Lipinski, C. A., Lombardo, F., Dominy, B. W., & Feeney, P. J. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(00)00129-0 · Cited by 18,139

Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness

Nishita, M., Park, S.-Y., Nishio, T., Kamizaki, K., Wang, Z., Tamada, K., Takumi, T., Hashimoto, R., Otani, H., Pazour, G. J., et al. (2017) · Scientific Reports · doi:10.1038/s41598-016-0028-x · Cited by 15,947

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

Lipinski, C. A., Lombardo, F., Dominy, B. W., & Feeney, P. J. (1997) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(96)00423-1 · Cited by 11,385

Nano based drug delivery systems: recent developments and future prospects

Patra, J. K., Das, G., Fraceto, L. F., Campos, E. V. R., Rodriguez-Torres, M. D. P., Acosta-Torres, L. S., Diaz-Torres, L. A., Grillo, R., Swamy, M. K., Sharma, S., et al. (2018) · Journal of Nanobiotechnology · doi:10.1186/s12951-018-0392-8 · Cited by 6,684

A Theoretical Basis for a Biopharmaceutic Drug Classification: The Correlation of in Vitro Drug Product Dissolution and in Vivo Bioavailability

Amidon, G. L., Lennernäs, H., Shah, V. P., & Crison, J. R. (1995) · Pharmaceutical Research · doi:10.1023/a:1016212804288 · Cited by 5,430

Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

Lovering, F., Bikker, J., & Humblet, C. (2009) · Journal of Medicinal Chemistry · doi:10.1021/jm901241e · Cited by 4,495

Diarylethenes for Memories and Switches

Irie, M. (2000) · Chemical Reviews · doi:10.1021/cr980069d · Cited by 4,157

Atomic structure and chemistry of human serum albumin

He, X. M., & Carter, D. C. (1992) · Nature · doi:10.1038/358209a0 · Cited by 3,824

Photoisomerization in different classes of azobenzene

Bandara, H. M. D., & Burdette, S. C. (2012) · Chem. Soc. Rev. · doi:10.1039/c1cs15179g · Cited by 3,095

Cellular uptake of the tat protein from human immunodeficiency virus

Frankel, A. D., & Pabo, C. O. (1988) · Cell · doi:10.1016/0092-8674(88)90263-2 · Cited by 2,783

TRP channels as cellular sensors

Clapham, D. E. (2003) · Nature · doi:10.1038/nature02196 · Cited by 2,779

Photochromism of Diarylethene Molecules and Crystals: Memories, Switches, and Actuators

Irie, M., Fukaminato, T., Matsuda, K., & Kobatake, S. (2014) · Chemical Reviews · doi:10.1021/cr500249p · Cited by 2,725

Modern physical organic chemistry

(2006) · Choice Reviews Online · doi:10.5860/choice.43-3398 · Cited by 2,312

Albumin as a drug carrier: Design of prodrugs, drug conjugates and nanoparticles

Kratz, F. (2008) · Journal of Controlled Release · doi:10.1016/j.jconrel.2008.05.010 · Cited by 2,151

March's Advanced Organic Chemistry: Reactions, Mechanisms, and Structure

Smith, M. B., & March, J. (2006) · doi:10.1002/0470084960 · Cited by 2,089

Spiropyran-based dynamic materials

Klajn, R. (2014) · Chem. Soc. Rev. · doi:10.1039/c3cs60181a · Cited by 2,058

Structural Basis of the Drug-binding Specificity of Human Serum Albumin

Ghuman, J., Zunszain, P. A., Petitpas, I., Bhattacharya, A. A., Otagiri, M., & Curry, S. (2005) · Journal of Molecular Biology · doi:10.1016/j.jmb.2005.07.075 · Cited by 1,941

Light-driven monodirectional molecular rotor

Koumura, N., Zijlstra, R. W. J., van Delden, R. A., Harada, N., & Feringa, B. L. (1999) · Nature · doi:10.1038/43646 · Cited by 1,923

Fluorescence microscopy with diffraction resolution barrier broken by stimulated emission

Klar, T. A., Jakobs, S., Dyba, M., Egner, A., & Hell, S. W. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.15.8206 · Cited by 1,869

Subdiffraction‐Resolution Fluorescence Imaging with Conventional Fluorescent Probes

Heilemann, M., van de Linde, S., Schüttpelz, M., Kasper, R., Seefeldt, B., Mukherjee, A., Tinnefeld, P., & Sauer, M. (2008) · Angewandte Chemie International Edition · doi:10.1002/anie.200802376 · Cited by 1,866

Azobenzene photoswitches for biomolecules

Beharry, A. A., & Woolley, G. A. (2011) · Chemical Society Reviews · doi:10.1039/c1cs15023e · Cited by 1,851

Photoremovable Protecting Groups in Chemistry and Biology: Reaction Mechanisms and Efficacy

Klán, P., Šolomek, T., Bochet, C. G., Blanc, A., Givens, R., Rubina, M., Popik, V., Kostikov, A., & Wirz, J. (2013) · Chemical Reviews · doi:10.1021/cr300177k · Cited by 1,827

Photochromism : molecules and systems

Dürr, H., & Bouas‐Laurent, H. (2003) · Cited by 1,708

Mitochondria-Targeted Triphenylphosphonium-Based Compounds: Syntheses, Mechanisms of Action, and Therapeutic and Diagnostic Applications

Zielonka, J., Joseph, J., Sikora, A., Hardy, M., Ouari, O., Vasquez-Vivar, J., Cheng, G., Lopez, M., & Kalyanaraman, B. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00042 · Cited by 1,683

Protein aggregation and aggregate toxicity: new insights into protein folding, misfolding diseases and biological evolution

Stefani, M., & Dobson, C. M. (2003) · Journal of Molecular Medicine · doi:10.1007/s00109-003-0464-5 · Cited by 1,651

High-water-content mouldable hydrogels by mixing clay and a dendritic molecular binder

Wang, Q., Mynar, J. L., Yoshida, M., Lee, E., Lee, M., Okuro, K., Kinbara, K., & Aida, T. (2010) · Nature · doi:10.1038/nature08693 · Cited by 1,580

Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates

Blagden, N., de Matas, M., Gavan, P. T., & York, P. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.05.011 · Cited by 1,448

Salt formation to improve drug solubility

Serajuddin, A. T. M. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.05.010 · Cited by 1,425

Acetylcholine as a Neuromodulator: Cholinergic Signaling Shapes Nervous System Function and Behavior

Picciotto, M. R., Higley, M. J., & Mineur, Y. S. (2012) · Neuron · doi:10.1016/j.neuron.2012.08.036 · Cited by 1,404

Photoisomerization dynamics of stilbenes

Waldeck, D. H. (1991) · Chemical Reviews · doi:10.1021/cr00003a007 · Cited by 1,348

Fluorescent probes for super-resolution imaging in living cells

Fernández-Suárez, M., & Ting, A. Y. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2531 · Cited by 1,306

Reversible Photocontrol of Biological Systems by the Incorporation of Molecular Photoswitches

Szymański, W., Beierle, J. M., Kistemaker, H. A. V., Velema, W. A., & Feringa, B. L. (2013) · Chemical Reviews · doi:10.1021/cr300179f · Cited by 1,239

Nuclear Receptors, RXR, and the Big Bang

Evans, R. M., & Mangelsdorf, D. J. (2014) · Cell · doi:10.1016/j.cell.2014.03.012 · Cited by 1,200

Glossary of terms used in photochemistry, 3rd edition (IUPAC Recommendations 2006)

Braslavsky, S. E. (2007) · Pure and Applied Chemistry · doi:10.1351/pac200779030293 · Cited by 1,192

Photopharmacology: Beyond Proof of Principle

Velema, W. A., Szymanski, W., & Feringa, B. L. (2014) · Journal of the American Chemical Society · doi:10.1021/ja413063e · Cited by 1,178

Bioconjugate Techniques

(2013) · Elsevier eBooks · doi:10.1016/c2009-0-64240-9 · Cited by 1,139

Small molecules, big targets: drug discovery faces the protein–protein interaction challenge

Scott, D. E., Bayly, A. R., Abell, C., & Skidmore, J. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.29 · Cited by 1,137

Advances in Chemical Protein Modification

Boutureira, O., & Bernardes, G. J. L. (2015) · Chemical Reviews · doi:10.1021/cr500399p · Cited by 1,132

Cold Denaturation of Protein

Privalov, P. L. (1990) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409239009090612 · Cited by 1,071

Small-Molecule Inhibitors of Protein-Protein Interactions: Progressing toward the Reality

Arkin, M. R., Tang, Y., & Wells, J. A. (2014) · Chemistry & Biology · doi:10.1016/j.chembiol.2014.09.001 · Cited by 1,065

Navigating chemical space for biology and medicine

Lipinski, C., & Hopkins, A. (2004) · Nature · doi:10.1038/nature03193 · Cited by 1,002

Pharmaceutical particle technologies: An approach to improve drug solubility, dissolution and bioavailability

Khadka, P., Ro, J., Kim, H., Kim, I., Kim, J. T., Kim, H., Cho, J. M., Yun, G., & Lee, J. (2014) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2014.05.005 · Cited by 998

Organic photochromism (IUPAC Technical Report)

Bouas-Laurent, H., & Dürr, H. (2001) · Pure and Applied Chemistry · doi:10.1351/pac200173040639 · Cited by 957

Light‐Controlled Tools

Brieke, C., Rohrbach, F., Gottschalk, A., Mayer, G., & Heckel, A. (2012) · Angewandte Chemie International Edition · doi:10.1002/anie.201202134 · Cited by 955

Artificial molecular motors

Kassem, S., van Leeuwen, T., Lubbe, A. S., Wilson, M. R., Feringa, B. L., & Leigh, D. A. (2017) · Chemical Society Reviews · doi:10.1039/c7cs00245a · Cited by 934

In Vivo Photopharmacology

Hüll, K., Morstein, J., & Trauner, D. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00037 · Cited by 921

The Structure and Function of DNA G-Quadruplexes

Spiegel, J., Adhikari, S., & Balasubramanian, S. (2020) · Trends in Chemistry · doi:10.1016/j.trechm.2019.07.002 · Cited by 920

o-Fluoroazobenzenes as Readily Synthesized Photoswitches Offering Nearly Quantitative Two-Way Isomerization with Visible Light

Bléger, D., Schwarz, J., Brouwer, A. M., & Hecht, S. (2012) · Journal of the American Chemical Society · doi:10.1021/ja310323y · Cited by 902

Effective drug delivery by PEGylated drug conjugates

Greenwald, R. B., Choe, Y. H., McGuire, J., & Conover, C. D. (2003) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00180-1 · Cited by 869

Getting Across the Cell Membrane: An Overview for Small Molecules, Peptides, and Proteins

Yang, N. J., & Hinner, M. J. (2015) · Methods in Molecular Biology · doi:10.1007/978-1-4939-2272-7_3 · Cited by 826

Cell-penetrating peptides: classes, origin, and current landscape

Milletti, F. (2012) · Drug Discovery Today · doi:10.1016/j.drudis.2012.03.002 · Cited by 813

Pore-forming toxins: ancient, but never really out of fashion

Peraro, M. D., & van der Goot, F. G. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2015.3 · Cited by 788

The evolution of spiropyran: fundamentals and progress of an extraordinarily versatile photochrome

Kortekaas, L., & Browne, W. R. (2019) · Chemical Society Reviews · doi:10.1039/c9cs00203k · Cited by 781

Synthesis of azobenzenes: the coloured pieces of molecular materials

Merino, E. (2011) · Chemical Society Reviews · doi:10.1039/c0cs00183j · Cited by 768

The expanding role of prodrugs in contemporary drug design and development

Rautio, J., Meanwell, N. A., Di, L., & Hageman, M. J. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2018.46 · Cited by 767

Predicting azo dye toxicity

Brown, M. A., & De Vito, S. C. (1993) · Critical Reviews in Environmental Science and Technology · doi:10.1080/10643389309388453 · Cited by 765

Design and Applications of Photoresponsive Hydrogels

Li, L., Scheiger, J. M., & Levkin, P. A. (2019) · Advanced Materials · doi:10.1002/adma.201807333 · Cited by 733

Transgenic Aedes aegypti Mosquitoes Transfer Genes into a Natural Population

Evans, B. R., Kotsakiozi, P., Costa-da-Silva, A. L., Ioshino, R. S., Garziera, L., Pedrosa, M. C., Malavasi, A., Virginio, J. F., Capurro, M. L., & Powell, J. R. (2019) · Scientific Reports · doi:10.1038/s41598-019-49660-6 · Cited by 732

A Roadmap to Success in Photopharmacology

Broichhagen, J., Frank, J. A., & Trauner, D. (2015) · Accounts of Chemical Research · doi:10.1021/acs.accounts.5b00129 · Cited by 730

Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system

Taly, A., Corringer, P.-J., Guedin, D., Lestage, P., & Changeux, J.-P. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2927 · Cited by 703

Emerging Targets in Photopharmacology

Lerch, M. M., Hansen, M. J., van Dam, G. M., Szymanski, W., & Feringa, B. L. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201601931 · Cited by 675

Red-Shifting Azobenzene Photoswitches for in Vivo Use

Dong, M., Babalhavaeji, A., Samanta, S., Beharry, A. A., & Woolley, G. A. (2015) · Accounts of Chemical Research · doi:10.1021/acs.accounts.5b00270 · Cited by 673

Hydrazone-based switches, metallo-assemblies and sensors

Su, X., & Aprahamian, I. (2014) · Chemical Society Reviews · doi:10.1039/c3cs60385g · Cited by 668

A general method to fine-tune fluorophores for live-cell and in vivo imaging

Grimm, J. B., Muthusamy, A. K., Liang, Y., Brown, T. A., Lemon, W. C., Patel, R., Lu, R., Macklin, J. J., Keller, P. J., Ji, N., et al. (2017) · Nature Methods · doi:10.1038/nmeth.4403 · Cited by 665

The trypanosomiases

Barrett, M. P., Burchmore, R. J., Stich, A., Lazzari, J. O., Frasch, A. C., Cazzulo, J. J., & Krishna, S. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14694-6 · Cited by 656

Heteroaryl azo dyes as molecular photoswitches

Crespi, S., Simeth, N. A., & König, B. (2019) · Nature Reviews Chemistry · doi:10.1038/s41570-019-0074-6 · Cited by 650

Chemical Modification of Proteins at Cysteine: Opportunities in Chemistry and Biology

Chalker, J. M., Bernardes, G. J. L., Lin, Y. A., & Davis, B. G. (2009) · Chemistry – An Asian Journal · doi:10.1002/asia.200800427 · Cited by 649

Improvement in Aqueous Solubility in Small Molecule Drug Discovery Programs by Disruption of Molecular Planarity and Symmetry

Ishikawa, M., & Hashimoto, Y. (2011) · Journal of Medicinal Chemistry · doi:10.1021/jm101356p · Cited by 619

Highly Efficient Reversible Z−E Photoisomerization of a Bridged Azobenzene with Visible Light through Resolved S1(nπ*) Absorption Bands

Siewertsen, R., Neumann, H., Buchheim-Stehn, B., Herges, R., Näther, C., Renth, F., & Temps, F. (2009) · Journal of the American Chemical Society · doi:10.1021/ja906547d · Cited by 594

One-Way Optoelectronic Switching of Photochromic Molecules on Gold

Dulić, D., van der Molen, S. J., Kudernac, T., Jonkman, H. T., de Jong, J. J. D., Bowden, T. N., van Esch, J., Feringa, B. L., & van Wees, B. J. (2003) · Physical Review Letters · doi:10.1103/physrevlett.91.207402 · Cited by 592

Enlightening Materials with Photoswitches

Goulet‐Hanssens, A., Eisenreich, F., & Hecht, S. (2020) · Advanced Materials · doi:10.1002/adma.201905966 · Cited by 577

Allosteric control of an ionotropic glutamate receptor with an optical switch

Volgraf, M., Gorostiza, P., Numano, R., Kramer, R. H., Isacoff, E. Y., & Trauner, D. (2006) · Nature Chemical Biology · doi:10.1038/nchembio756 · Cited by 573

Drug delivery strategies for poorly water-soluble drugs

Fahr, A., & Liu, X. (2007) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.4.4.403 · Cited by 568

When poor solubility becomes an issue: From early stage to proof of concept

Stegemann, S., Leveiller, F., Franchi, D., de Jong, H., & Lindén, H. (2007) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2007.05.110 · Cited by 567

Deep Architectures and Deep Learning in Chemoinformatics: The Prediction of Aqueous Solubility for Drug-Like Molecules

Lusci, A., Pollastri, G., & Baldi, P. (2013) · Journal of Chemical Information and Modeling · doi:10.1021/ci400187y · Cited by 555

Photoswitching Using Visible Light: A New Class of Organic Photochromic Molecules

Helmy, S., Leibfarth, F. A., Oh, S., Poelma, J. E., Hawker, C. J., & Read de Alaniz, J. (2014) · Journal of the American Chemical Society · doi:10.1021/ja503016b · Cited by 542

Photo- and Redox-Driven Artificial Molecular Motors

Baroncini, M., Silvi, S., & Credi, A. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00291 · Cited by 538

Photoswitching Azo Compounds in Vivo with Red Light

Samanta, S., Beharry, A. A., Sadovski, O., McCormick, T. M., Babalhavaeji, A., Tropepe, V., & Woolley, G. A. (2013) · Journal of the American Chemical Society · doi:10.1021/ja402220t · Cited by 536

Unidirectional molecular motor on a gold surface

van Delden, R. A., ter Wiel, M. K. J., Pollard, M. M., Vicario, J., Koumura, N., & Feringa, B. L. (2005) · Nature · doi:10.1038/nature04127 · Cited by 531

State of the art paper Sulfonylureas and their use in clinical practice

Sola, D., Rossi, L., Schianca, G. P. C., Maffioli, P., Bigliocca, M., Mella, R., Corlianò, F., Fra, G. P., Bartoli, E., & Derosa, G. (2015) · Archives of Medical Science · doi:10.5114/aoms.2015.53304 · Cited by 514

Arylazopyrazoles: Azoheteroarene Photoswitches Offering Quantitative Isomerization and Long Thermal Half-Lives

Weston, C. E., Richardson, R. D., Haycock, P., White, A. J. P., & Fuchter, M. J. (2014) · Journal of the American Chemical Society · doi:10.1021/ja505444d · Cited by 493

Glutathione metabolism and its role in hepatotoxicity

DeLeve, L. D., & Kaplowitz, N. (1991) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(91)90029-l · Cited by 492

Study of equilibrium solubility measurement by saturation shake-flask method using hydrochlorothiazide as model compound

Baka, E., Comer, J. E. A., & Takács‐Novák, K. (2007) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2007.10.030 · Cited by 481

Cosolvent Effects on Protein Stability

Canchi, D. R., & García, A. E. (2013) · Annual Review of Physical Chemistry · doi:10.1146/annurev-physchem-040412-110156 · Cited by 479

Expanding and Reprogramming the Genetic Code of Cells and Animals

Chin, J. W. (2014) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060713-035737 · Cited by 476

Recent advances in photoresponsive supramolecular self-assemblies

Yagai, S., & Kitamura, A. (2008) · Chemical Society Reviews · doi:10.1039/b703092b · Cited by 473

Photoswitchable Supramolecular Hydrogels Formed by Cyclodextrins and Azobenzene Polymers

Tamesue, S., Takashima, Y., Yamaguchi, H., Shinkai, S., & Harada, A. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.201003567 · Cited by 468

Photoswitchable gel assembly based on molecular recognition

Yamaguchi, H., Kobayashi, Y., Kobayashi, R., Takashima, Y., Hashidzume, A., & Harada, A. (2012) · Nature Communications · doi:10.1038/ncomms1617 · Cited by 456

A Critical and Comparative Review of Fluorescent Tools for Live-Cell Imaging

Specht, E. A., Braselmann, E., & Palmer, A. E. (2017) · Annual Review of Physiology · doi:10.1146/annurev-physiol-022516-034055 · Cited by 444

ortho‐Fluoroazobenzenes: Visible Light Switches with Very Long‐Lived Z Isomers

Knie, C., Utecht, M., Zhao, F., Kulla, H., Kovalenko, S., Brouwer, A. M., Saalfrank, P., Hecht, S., & Bléger, D. (2014) · Chemistry – A European Journal · doi:10.1002/chem.201404649 · Cited by 438

Tuning Azoheteroarene Photoswitch Performance through Heteroaryl Design

Calbo, J., Weston, C. E., White, A. J. P., Rzepa, H. S., Contreras-García, J., & Fuchter, M. J. (2017) · Journal of the American Chemical Society · doi:10.1021/jacs.6b11626 · Cited by 428

Optogenetic dissection of a behavioural module in the vertebrate spinal cord

Wyart, C., Bene, F. D., Warp, E., Scott, E. K., Trauner, D., Baier, H., & Isacoff, E. Y. (2009) · Nature · doi:10.1038/nature08323 · Cited by 409

Improving the Fatigue Resistance of Diarylethene Switches

Herder, M., Schmidt, B. M., Grubert, L., Pätzel, M., Schwarz, J., & Hecht, S. (2015) · Journal of the American Chemical Society · doi:10.1021/ja513027s · Cited by 404

Remote-controlling chemical reactions by light: Towards chemistry with high spatio-temporal resolution

Göstl, R., Senf, A., & Hecht, S. (2014) · Chemical Society Reviews · doi:10.1039/c3cs60383k · Cited by 401

On Protein Denaturation in Aqueous−Organic Mixtures but Not in Pure Organic Solvents

Griebenow, K., & Klibanov, A. M. (1996) · Journal of the American Chemical Society · doi:10.1021/ja961869d · Cited by 400

An Overview of Drug Discovery and Development

Berdigaliyev, N., & Aljofan, M. (2020) · Future Medicinal Chemistry · doi:10.4155/fmc-2019-0307 · Cited by 396

Wavelength-selective cleavage of photoprotecting groups: strategies and applications in dynamic systems

Hansen, M. J., Velema, W. A., Lerch, M. M., Szymanski, W., & Feringa, B. L. (2015) · Chemical Society Reviews · doi:10.1039/c5cs00118h · Cited by 395

RNA Drugs and RNA Targets for Small Molecules: Principles, Progress, and Challenges

Yu, A.-M., Choi, Y. H., & Tu, M.-J. (2020) · Pharmacological Reviews · doi:10.1124/pr.120.019554 · Cited by 395

Antibody Drug Conjugates: Design and Selection of Linker, Payload and Conjugation Chemistry

McCombs, J. R., & Owen, S. C. (2015) · The AAPS Journal · doi:10.1208/s12248-014-9710-8 · Cited by 393

Azobenzene-Based Light-Responsive Hydrogel System

Zhao, Y.-L., & Stoddart, J. F. (2009) · Langmuir · doi:10.1021/la804316u · Cited by 387

PEGylation in anti-cancer therapy: An overview

Mishra, P., Nayak, B., & Dey, R. K. (2016) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2015.08.011 · Cited by 382

Photoswitching Mechanism of Cyanine Dyes

Dempsey, G. T., Bates, M., Kowtoniuk, W. E., Liu, D. R., Tsien, R. Y., & Zhuang, X. (2009) · Journal of the American Chemical Society · doi:10.1021/ja904588g · Cited by 380

Mechanosensitive Channels: What Can They Do and How Do They Do It?

Haswell, E. S., Phillips, R., & Rees, D. C. (2011) · Structure · doi:10.1016/j.str.2011.09.005 · Cited by 378

Optical control of antibacterial activity

Velema, W. A., van der Berg, J. P., Hansen, M. J., Szymanski, W., Driessen, A. J. M., & Feringa, B. L. (2013) · Nature Chemistry · doi:10.1038/nchem.1750 · Cited by 371

Photochromic and Luminescence Switching Properties of a Versatile Diarylethene-Containing 1,10-Phenanthroline Ligand and Its Rhenium(I) Complex

Yam, V. W.-W., Ko, C.-C., & Zhu, N. (2004) · Journal of the American Chemical Society · doi:10.1021/ja047446q · Cited by 363

Improving cellular uptake of therapeutic entities through interaction with components of cell membrane

Zhang, R., Qin, X., Kong, F., Chen, P., & Pan, G. (2019) · Drug Delivery · doi:10.1080/10717544.2019.1582730 · Cited by 363

Recent Advances in Scaffold Hopping: Miniperspective

Hu, Y., Stumpfe, D., & Bajorath, J. (2017) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6b01437 · Cited by 361

On the Promise of Photopharmacology Using Photoswitches: A Medicinal Chemist’s Perspective

Fuchter, M. J. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c00629 · Cited by 343

The denaturation and degradation of stable enzymes at high temperatures

DANIEL, R. M., DINES, M., & PETACH, H. H. (1996) · Biochemical Journal · doi:10.1042/bj3170001 · Cited by 336

Recent developments in reversible photoregulation of oligonucleotide structure and function

Lubbe, A. S., Szymanski, W., & Feringa, B. L. (2017) · Chemical Society Reviews · doi:10.1039/c6cs00461j · Cited by 336

Scaffold hopping

Böhm, H.-J., Flohr, A., & Stahl, M. (2004) · Drug Discovery Today: Technologies · doi:10.1016/j.ddtec.2004.10.009 · Cited by 335

Two-photon optogenetic toolbox for fast inhibition, excitation and bistable modulation

Prakash, R., Yizhar, O., Grewe, B., Ramakrishnan, C., Wang, N., Goshen, I., Packer, A. M., Peterka, D. S., Yuste, R., Schnitzer, M. J., et al. (2012) · Nature Methods · doi:10.1038/nmeth.2215 · Cited by 334

Indigoid Photoswitches: Visible Light Responsive Molecular Tools

Petermayer, C., & Dube, H. (2018) · Accounts of Chemical Research · doi:10.1021/acs.accounts.7b00638 · Cited by 332

Protein precipitation and denaturation by dimethyl sulfoxide

Arakawa, T., Kita, Y., & Timasheff, S. N. (2007) · Biophysical Chemistry · doi:10.1016/j.bpc.2007.09.004 · Cited by 329

Recent Implementations of Molecular Photoswitches into Smart Materials and Biological Systems

Pianowski, Z. L. (2019) · Chemistry – A European Journal · doi:10.1002/chem.201805814 · Cited by 328

Photocontrol of Antibacterial Activity: Shifting from UV to Red Light Activation

Wegener, M., Hansen, M. J., Driessen, A. J. M., Szymanski, W., & Feringa, B. L. (2017) · Journal of the American Chemical Society · doi:10.1021/jacs.7b09281 · Cited by 324

Switchable Fluorophores for Single-Molecule Localization Microscopy

Li, H., & Vaughan, J. C. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00767 · Cited by 319

Chemo- and Regioselective Lysine Modification on Native Proteins

Matos, M. J., Oliveira, B. L., Martínez-Sáez, N., Guerreiro, A., Cal, P. M. S. D., Bertoldo, J., Maneiro, M., Perkins, E., Howard, J., Deery, M. J., et al. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.7b12874 · Cited by 314

The (photo)chemistry of Stenhouse photoswitches: guiding principles and system design

Lerch, M. M., Szymański, W., & Feringa, B. L. (2018) · Chemical Society Reviews · doi:10.1039/c7cs00772h · Cited by 313

The Prodrug Approach: A Successful Tool for Improving Drug Solubility

Jornada, D., Dos Santos Fernandes, G., Chiba, D., De Melo, T., Dos Santos, J., & Chung, M. (2015) · Molecules · doi:10.3390/molecules21010042 · Cited by 294

Photo-control of helix content in a short peptide

Kumita, J. R., Smart, O. S., & Woolley, G. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.8.3803 · Cited by 291

Design and Synthesis of Donor–Acceptor Stenhouse Adducts: A Visible Light Photoswitch Derived from Furfural

Helmy, S., Oh, S., Leibfarth, F. A., Hawker, C. J., & Read de Alaniz, J. (2014) · The Journal of Organic Chemistry · doi:10.1021/jo502206g · Cited by 283

Tunable Visible and Near Infrared Photoswitches

Hemmer, J. R., Poelma, S. O., Treat, N., Page, Z. A., Dolinski, N. D., Diaz, Y. J., Tomlinson, W., Clark, K. D., Hooper, J. P., Hawker, C., et al. (2016) · Journal of the American Chemical Society · doi:10.1021/jacs.6b07434 · Cited by 280

Recent developments in anticancer drug delivery using cell penetrating and tumor targeting peptides

Dissanayake, S., Denny, W. A., Gamage, S., & Sarojini, V. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.02.006 · Cited by 280

Quantum Chemical Investigation of Thermal Cis-to-Trans Isomerization of Azobenzene Derivatives: Substituent Effects, Solvent Effects, and Comparison to Experimental Data

Dokić, J., Gothe, M., Wirth, J., Peters, M. V., Schwarz, J., Hecht, S., & Saalfrank, P. (2009) · The Journal of Physical Chemistry A · doi:10.1021/jp9021344 · Cited by 270

Photoresponsive molecular tools for emerging applications of light in medicine

Welleman, I. M., Hoorens, M. W. H., Feringa, B. L., Boersma, H. H., & Szymański, W. (2020) · Chemical Science · doi:10.1039/d0sc04187d · Cited by 265

Beware of proteins in DMSO

Jackson, M., & Mantsch, H. H. (1991) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/0167-4838(91)90563-f · Cited by 263

From One‐Photon to Two‐Photon Probes: “Caged” Compounds, Actuators, and Photoswitches

Bort, G., Gallavardin, T., Ogden, D., & Dalko, P. I. (2013) · Angewandte Chemie International Edition · doi:10.1002/anie.201204203 · Cited by 262

In Search of the Perfect Photocage: Structure–Reactivity Relationships in meso-Methyl BODIPY Photoremovable Protecting Groups

Slanina, T., Shrestha, P., Palao, E., Kand, D., Peterson, J. A., Dutton, A. S., Rubinstein, N., Weinstain, R., Winter, A. H., & Klán, P. (2017) · Journal of the American Chemical Society · doi:10.1021/jacs.7b08532 · Cited by 262

Thioindigo Dyes: Highly Accurate Visible Spectra with TD-DFT

Jacquemin, D., Preat, J., Wathelet, V., Fontaine, M., & Perpète, E. A. (2006) · Journal of the American Chemical Society · doi:10.1021/ja056676h · Cited by 260

Azobenzene as Conformational Switch in Model Peptides

Renner, C., & Moroder, L. (2006) · ChemBioChem · doi:10.1002/cbic.200500531 · Cited by 260

Recent progress in enzymatic protein labelling techniques and their applications

Zhang, Y., Park, K.-Y., Suazo, K. F., & Distefano, M. D. (2018) · Chemical Society Reviews · doi:10.1039/c8cs00537k · Cited by 256

Light-Activated Organic Molecular Motors and Their Applications

García-López, V., Liu, D., & Tour, J. M. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00221 · Cited by 255

Spectral Tuning of Azobenzene Photoswitches for Biological Applications

Sadovski, O., Beharry, A. A., Zhang, F., & Woolley, G. A. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200805013 · Cited by 254

Thirteen decades of peptide synthesis: key developments in solid phase peptide synthesis and amide bond formation utilized in peptide ligation

Jaradat, D. M. M. (2018) · Amino Acids · doi:10.1007/s00726-017-2516-0 · Cited by 253

Visible Light Switching of a BF2-Coordinated Azo Compound

Yang, Y., Hughes, R. P., & Aprahamian, I. (2012) · Journal of the American Chemical Society · doi:10.1021/ja306030d · Cited by 249

Cryoprotectant toxicity and cryoprotectant toxicity reduction: In search of molecular mechanisms

Fahy, G. M., Lilley, T. H., Linsdell, H., Douglas, M. S. J., & Meryman, H. T. (1990) · Cryobiology · doi:10.1016/0011-2240(90)90025-y · Cited by 249

Enzymatic Labeling of Proteins: Techniques and Approaches

Rashidian, M., Dozier, J. K., & Distefano, M. D. (2013) · Bioconjugate Chemistry · doi:10.1021/bc400102w · Cited by 244

Near-Infrared Photoswitching of Azobenzenes under Physiological Conditions

Dong, M., Babalhavaeji, A., Collins, C. V., Jarrah, K., Sadovski, O., Dai, Q., & Woolley, G. A. (2017) · Journal of the American Chemical Society · doi:10.1021/jacs.7b06471 · Cited by 243

Photochromic Blockers of Voltage‐Gated Potassium Channels

Banghart, M. R., Mourot, A., Fortin, D. L., Yao, J. Z., Kramer, R. H., & Trauner, D. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200904504 · Cited by 241

Sunlight-powered kHz rotation of a hemithioindigo-based molecular motor

Guentner, M., Schildhauer, M., Thumser, S., Mayer, P., Stephenson, D., Mayer, P. J., & Dube, H. (2015) · Nature Communications · doi:10.1038/ncomms9406 · Cited by 239

In Situ Preparation of Highly Fluorescent Dyes upon Photoirradiation

Uno, K., Niikura, H., Morimoto, M., Ishibashi, Y., Miyasaka, H., & Irie, M. (2011) · Journal of the American Chemical Society · doi:10.1021/ja204583e · Cited by 239

Loss of enteric dopaminergic neurons and associated changes in colon motility in an MPTP mouse model of Parkinson's disease

ANDERSON, G., NOORIAN, A., TAYLOR, G., ANITHA, M., BERNHARD, D., SRINIVASAN, S., & GREENE, J. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2007.05.010 · Cited by 238

Hemithioindigo—an emerging photoswitch

Wiedbrauk, S., & Dube, H. (2015) · Tetrahedron Letters · doi:10.1016/j.tetlet.2015.05.022 · Cited by 235

Discovery of 4-Amino-N-[(1 S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7 H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an Orally Bioavailable, Potent Inhibitor of Akt Kinases

Addie, M., Ballard, P., Buttar, D., Crafter, C., Currie, G., Davies, B. R., Debreczeni, J., Dry, H., Dudley, P., Greenwood, R., et al. (2013) · Journal of Medicinal Chemistry · doi:10.1021/jm301762v · Cited by 230

Fluorescent Photoswitchable Diarylethenes for Biolabeling and Single-Molecule Localization Microscopies with Optical Superresolution

Roubinet, B., Weber, M., Shojaei, H., Bates, M., Bossi, M. L., Belov, V. N., Irie, M., & Hell, S. W. (2017) · Journal of the American Chemical Society · doi:10.1021/jacs.7b00274 · Cited by 224

New molecular switch architectures

Harris, J. D., Moran, M. J., & Aprahamian, I. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1714499115 · Cited by 220

Simple Hydrazone Building Blocks for Complicated Functional Materials

Tatum, L. A., Su, X., & Aprahamian, I. (2014) · Accounts of Chemical Research · doi:10.1021/ar500111f · Cited by 219

Carbofluoresceins and Carborhodamines as Scaffolds for High-Contrast Fluorogenic Probes

Grimm, J. B., Sung, A. J., Legant, W. R., Hulamm, P., Matlosz, S. M., Betzig, E., & Lavis, L. D. (2013) · ACS Chemical Biology · doi:10.1021/cb4000822 · Cited by 217

Azobenzene photocontrol of peptides and proteins

Mart, R. J., & Allemann, R. K. (2016) · Chemical Communications · doi:10.1039/c6cc04004g · Cited by 216

Discovery of 4-{4-[(3 R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1 H-indole (AZ20): A Potent and Selective Inhibitor of ATR Protein Kinase with Monotherapy in Vivo Antitumor Activity

Foote, K. M., Blades, K., Cronin, A., Fillery, S., Guichard, S. S., Hassall, L., Hickson, I., Jacq, X., Jewsbury, P. J., McGuire, T. M., et al. (2013) · Journal of Medicinal Chemistry · doi:10.1021/jm301859s · Cited by 214

DNA compaction: fundamentals and applications

Estévez-Torres, A., & Baigl, D. (2011) · Soft Matter · doi:10.1039/c1sm05373f · Cited by 207

Chemical Methods for Peptide and Protein Production

Chandrudu, S., Simerska, P., & Toth, I. (2013) · Molecules · doi:10.3390/molecules18044373 · Cited by 207

Optical control of metabotropic glutamate receptors

Levitz, J., Pantoja, C., Gaub, B., Janovjak, H., Reiner, A., Hoagland, A., Schoppik, D., Kane, B., Stawski, P., Schier, A. F., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3346 · Cited by 205

Photochromic Fluorescent Probe Strategy for the Super-resolution Imaging of Biologically Important Biomarkers

Chai, X., Han, H.-H., Sedgwick, A. C., Li, N., Zang, Y., James, T. D., Zhang, J., Hu, X.-L., Yu, Y., Li, Y., et al. (2020) · Journal of the American Chemical Society · doi:10.1021/jacs.0c05379 · Cited by 205

Molecular All-Photonic Encoder−Decoder

Andréasson, J., Straight, S. D., Moore, T. A., Moore, A. L., & Gust, D. (2008) · Journal of the American Chemical Society · doi:10.1021/ja802845z · Cited by 204

Photochromic Hydrazone Switches with Extremely Long Thermal Half-Lives

Qian, H., Pramanik, S., & Aprahamian, I. (2017) · Journal of the American Chemical Society · doi:10.1021/jacs.7b04993 · Cited by 202

Imaging and writing at the nanoscale with focused visible light through saturable optical transitions

Hell, S. W., Jakobs, S., & Kastrup, L. (2003) · Applied Physics A: Materials Science & Processing · doi:10.1007/s00339-003-2292-4 · Cited by 201

Synthesis and potent antimicrobial activity of some novel methyl or ethyl 1H-benzimidazole-5-carboxylates derivatives carrying amide or amidine groups

Özden, S., Atabey, D., Yıldız, S., & Göker, H. (2005) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2004.12.025 · Cited by 199

Shape-Persistent Actuators from Hydrazone Photoswitches

Ryabchun, A., Li, Q., Lancia, F., Aprahamian, I., & Katsonis, N. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.8b11558 · Cited by 198

Super-resolution microscopy as a powerful tool to study complex synthetic materials

Pujals, S., Feiner-Gracia, N., Delcanale, P., Voets, I., & Albertazzi, L. (2019) · Nature Reviews Chemistry · doi:10.1038/s41570-018-0070-2 · Cited by 197

Predicting aqueous solubility from structure

Delaney, J. S. (2005) · Drug Discovery Today · doi:10.1016/s1359-6446(04)03365-3 · Cited by 191

Photon‐Quantitative Reaction of a Dithiazolylarylene in Solution

Fukumoto, S., Nakashima, T., & Kawai, T. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201006844 · Cited by 189

Looking Back, Looking Forward at Halogen Bonding in Drug Discovery

Mendez, L., Henriquez, G., Sirimulla, S., & Narayan, M. (2017) · Molecules · doi:10.3390/molecules22091397 · Cited by 189

The Incorporation of a Photoisomerizable Amino Acid into Proteins in E. c oli

Bose, M., Groff, D., Xie, J., Brustad, E., & Schultz, P. G. (2006) · Journal of the American Chemical Society · doi:10.1021/ja055467u · Cited by 188

Substituent effects on the physical properties and p Ka of phenol

Gross, K. C., & Seybold, P. G. (2001) · International Journal of Quantum Chemistry · doi:10.1002/qua.1525 · Cited by 187

Computational Design and Synthesis of a Deeply Red-Shifted and Bistable Azobenzene

Konrad, D. B., Savasci, G., Allmendinger, L., Trauner, D., Ochsenfeld, C., & Ali, A. M. (2020) · Journal of the American Chemical Society · doi:10.1021/jacs.9b10430 · Cited by 187

Switching Diarylethenes Reliably in Both Directions with Visible Light

Fredrich, S., Göstl, R., Herder, M., Grubert, L., & Hecht, S. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201509875 · Cited by 186

Molecular Design Strategy toward Diarylethenes That Photoswitch with Visible Light

Fukaminato, T., Hirose, T., Doi, T., Hazama, M., Matsuda, K., & Irie, M. (2014) · Journal of the American Chemical Society · doi:10.1021/ja5090749 · Cited by 185

Asymmetric Photocyclization of Diarylethene Derivatives

Yamaguchi, T., Uchida, K., & Irie, M. (1997) · Journal of the American Chemical Society · doi:10.1021/ja970200j · Cited by 181

Mechanisms of photoswitch conjugation and light activation of an ionotropic glutamate receptor

Gorostiza, P., Volgraf, M., Numano, R., Szobota, S., Trauner, D., & Isacoff, E. Y. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701274104 · Cited by 181

Nitrogen Bridged Diazocines: Photochromes Switching within the Near-Infrared Region with High Quantum Yields in Organic Solvents and in Water

Lentes, P., Stadler, E., Röhricht, F., Brahms, A., Gröbner, J., Sönnichsen, F. D., Gescheidt, G., & Herges, R. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.9b06104 · Cited by 181

Specific Two-Photon Imaging of Live Cellular and Deep-Tissue Lipid Droplets by Lipophilic AIEgens at Ultralow Concentration

Niu, G., Zhang, R., Kwong, J. P. C., Lam, J. W. Y., Chen, C., Wang, J., Chen, Y., Feng, X., Kwok, R. T. K., Sung, H. H.-Y., et al. (2018) · Chemistry of Materials · doi:10.1021/acs.chemmater.8b01943 · Cited by 180

Unraveling the Photoswitching Mechanism in Donor–Acceptor Stenhouse Adducts

Lerch, M. M., Wezenberg, S. J., Szymanski, W., & Feringa, B. L. (2016) · Journal of the American Chemical Society · doi:10.1021/jacs.6b01722 · Cited by 179

Rapid optical control of nociception with an ion-channel photoswitch

Mourot, A., Fehrentz, T., Le Feuvre, Y., Smith, C. M., Herold, C., Dalkara, D., Nagy, F., Trauner, D., & Kramer, R. H. (2012) · Nature Methods · doi:10.1038/nmeth.1897 · Cited by 177

An allosteric modulator to control endogenous G protein-coupled receptors with light

Pittolo, S., Gómez-Santacana, X., Eckelt, K., Rovira, X., Dalton, J., Goudet, C., Pin, J.-P., Llobet, A., Giraldo, J., Llebaria, A., et al. (2014) · Nature Chemical Biology · doi:10.1038/nchembio.1612 · Cited by 177

Strategy for far-field optical imaging and writing without diffraction limit

Hell, S. W. (2004) · Physics Letters A · doi:10.1016/j.physleta.2004.03.082 · Cited by 177

Photochromic Materials: Preparation, Properties and Applications

(2016) · Wiley-VCH eBooks · doi:10.1002/9783527683734 · Cited by 177

Self‐Assembly of Photoresponsive Molecular Amphiphiles in Aqueous Media

Chen, S., Costil, R., Leung, F. K., & Feringa, B. L. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202007693 · Cited by 177

Controlling Dark Equilibria and Enhancing Donor–Acceptor Stenhouse Adduct Photoswitching Properties through Carbon Acid Design

Hemmer, J. R., Page, Z. A., Clark, K. D., Stricker, F., Dolinski, N. D., Hawker, C. J., & Read de Alaniz, J. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.8b06067 · Cited by 175

Optochemical control of genetically engineered neuronal nicotinic acetylcholine receptors

Tochitsky, I., Banghart, M. R., Mourot, A., Yao, J. Z., Gaub, B., Kramer, R. H., & Trauner, D. (2012) · Nature Chemistry · doi:10.1038/nchem.1234 · Cited by 172

Hydrazone switches and things in between

Aprahamian, I. (2017) · Chemical Communications · doi:10.1039/c7cc02879b · Cited by 169

Using an Azobenzene Cross-Linker to Either Increase or Decrease Peptide Helix Content upon Trans-to-Cis Photoisomerization

Flint, D. G., Kumita, J. R., Smart, O. S., & Woolley, G. A. (2002) · Chemistry & Biology · doi:10.1016/s1074-5521(02)00109-6 · Cited by 167

Characterization of very acidic phagosomes in breast cancer cells and their association with invasion

Montcourrier, P., Mangeat, P. H., Valembois, C., Salazar, G., Sahuquet, A., Duperray, C., & Rochefort, H. (1994) · Journal of Cell Science · doi:10.1242/jcs.107.9.2381 · Cited by 167

ZK200775: A phosphonate quinoxalinedione AMPA antagonist for neuroprotection in stroke and trauma

Turski, L., Huth, A., Sheardown, M., McDonald, F., Neuhaus, R., Schneider, H. H., Dirnagl, U., Wiegand, F., Jacobsen, P., & Ottow, E. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.18.10960 · Cited by 165

The Photochemical cis–trans Isomerization of Free Stilbene Molecules Follows a Hula‐Twist Pathway

Fuß, W., Kosmidis, C., Schmid, W. E., & Trushin, S. A. (2004) · Angewandte Chemie International Edition · doi:10.1002/anie.200454221 · Cited by 165

Site-Selective Protein Modification: From Functionalized Proteins to Functional Biomaterials

Shadish, J. A., & DeForest, C. A. (2020) · Matter · doi:10.1016/j.matt.2019.11.011 · Cited by 165

Robust visible light photoswitching with ortho-thiol substituted azobenzenes

Samanta, S., McCormick, T. M., Schmidt, S. K., Seferos, D. S., & Woolley, G. A. (2013) · Chemical Communications · doi:10.1039/c3cc46045b · Cited by 164

N , N ′-Disubstituted Indigos as Readily Available Red-Light Photoswitches with Tunable Thermal Half-Lives

Huang, C.-Y. D., Bonasera, A., Hristov, L. V., Garmshausen, Y., Schmidt, B. M., Jacquemin, D., & Hecht, S. (2017) · Journal of the American Chemical Society · doi:10.1021/jacs.7b08726 · Cited by 164

Photoswitching of ortho‐Substituted Azonium Ions by Red Light in Whole Blood

Samanta, S., Babalhavaeji, A., Dong, M., & Woolley, G. A. (2013) · Angewandte Chemie International Edition · doi:10.1002/anie.201306352 · Cited by 161

Novel Photochromic Molecules Based on 4,5-Dithienyl Thiazole with Fast Thermal Bleaching Rate

Kawai, S., Nakashima, T., Atsumi, K., Sakai, T., Harigai, M., Imamoto, Y., Kamikubo, H., Kataoka, M., & Kawai, T. (2007) · Chemistry of Materials · doi:10.1021/cm0630340 · Cited by 160

Structure Property Analysis of the Solution and Solid-State Properties of Bistable Photochromic Hydrazones

Shao, B., Qian, H., Li, Q., & Aprahamian, I. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.9b03932 · Cited by 159

Carboxylated Photoswitchable Diarylethenes for Biolabeling and Super‐Resolution RESOLFT Microscopy

Roubinet, B., Bossi, M. L., Alt, P., Leutenegger, M., Shojaei, H., Schnorrenberg, S., Nizamov, S., Irie, M., Belov, V. N., & Hell, S. W. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201607940 · Cited by 158

Hemiindigo: Highly Bistable Photoswitching at the Biooptical Window

Petermayer, C., Thumser, S., Kink, F., Mayer, P., & Dube, H. (2017) · Journal of the American Chemical Society · doi:10.1021/jacs.7b07531 · Cited by 158

Conductance Photoswitching of Metal–Organic Frameworks with Embedded Spiropyran

Garg, S., Schwartz, H., Kozlowska, M., Kanj, A. B., Müller, K., Wenzel, W., Ruschewitz, U., & Heinke, L. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201811458 · Cited by 158

Development and Therapeutic Potential of Small-Molecule Modulators of Circadian Systems

Chen, Z., Yoo, S. H., & Takahashi, J. S. (2017) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010617-052645 · Cited by 157

Fluorescence Imaging of Azobenzene Photoswitching In Vivo

Beharry, A. A., Wong, L., Tropepe, V., & Woolley, G. A. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201006506 · Cited by 156

Estimation of the Aqueous Solubility of Organic Molecules by the Group Contribution Approach

Klopman, G., & Zhu, H. (2001) · Journal of Chemical Information and Computer Sciences · doi:10.1021/ci000152d · Cited by 155

Solubility: it's not just for physical chemists

Bhattachar, S., Deschenes, L. A., & Wesley, J. A. (2006) · Drug Discovery Today · doi:10.1016/j.drudis.2006.09.002 · Cited by 155

Photoregulation of cyclic peptide conformation.

Ulysse, L. G., Cubillos, J., & Chmielewski, J. A. (1995) · Journal of the American Chemical Society · doi:10.1021/ja00137a023 · Cited by 153

Visible‐ and Near‐Infrared Light‐Driven Molecular Photoswitches for Biological Applications

Xu, Y., Tang, Y., & Li, Q. (2025) · Advanced Functional Materials · doi:10.1002/adfm.202416359 · Cited by 49

Expanding the Repertoire of Photoswitchable Unnatural Amino Acids for Enzyme Engineering

Hiefinger, C., Marcon, M., Pape, V., Casadevall, G., Lahmy, R., Haag, C., Nazet, J., Bartl, M., Bruckmann, A., Osuna, S., et al. (2025) · Angewandte Chemie International Edition · doi:10.1002/anie.202508562 · Cited by 5

Expanding the Repertoire of Photoswitchable Unnatural Amino Acids for Enzyme Engineering

Hiefinger, C., Marcon, M., Pape, V., Casadevall, G., Lahmy, R., Nazet, J., Bartl, M., Bruckmann, A., Osuna, S., König, B., et al. (2025) · doi:10.1101/2025.04.17.649278 · Cited by 2