Cited by 190Wood and Agarwood ResearchNatural Compound Pharmacology StudiesPharmacological Effects of Medicinal Plants

Natural products in agarwood and Aquilaria plants: chemistry, biological activities and biosynthesis

Li, Wei, Chen, Hui-Qin, Wang, Hao, Mei, Wen-Li, Dai, Hao-Fu·2021·Natural Product Reports

Abstract

Covering: Up to the end of 2019.Agarwood is a resinous portion of Aquilaria trees, which is formed in response to environmental stress factors such as physical injury or microbial attack. It is very sought-after among the natural incenses, as well as for its medicinal properties in traditional Chinese and Ayurvedic medicine. Interestingly, the chemical constituents of agarwood and healthy Aquilaria trees are quite different. Sesquiterpenes and 2-(2-phenethyl)chromones with diverse scaffolds commonly accumulate in agarwood. Similar structures have rarely been reported from the original trees that mainly contain flavonoids, benzophenones, xanthones, lignans, simple phenolic compounds, megastigmanes, diterpenoids, triterpenoids, steroids, alkaloids, etc. This review summarizes the chemical constituents and biological activities both in agarwood and Aquilaria trees, and their biosynthesis is discussed in order to give a comprehensive overview of the research progress on agarwood.

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Registry

Crossref · 10.1039/d0np00042f

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197 of 197 references verified0 citation errors · 0 not checkable

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  • The metabolism, bioavailability, and biological activity of flavonoids depend upon the configuration, total number of hydroxyl groups, and substitution of functional groups about their nuclear structure.

    “For example, the metabolism, bioavailability, and biological activity of flavonoids depend upon the configuration, total number of hydroxyl groups, and substitution of functional groups about their nuclear structure [109].”

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Authors
Li, W., Chen, H.-Q., Wang, H., Mei, W.-L., & Dai, H.-F.
Affiliations
  • Chinese Academy of Tropical Agricultural Sciences (CN)
  • Hainan Engineering Research Center of Agarwood
Corresponding author
  • Mei, Wen-Li
  • Dai, Hao-Fu
Venue
Natural Product Reports
Published
2021
Volume
38
Issue
3
Pages
528-565
ISSN
  • 0265-0568 (ISSN-L)
  • 1460-4752
OpenAlex
W3089852545
Cited by
190
References
197
Citations by year
2026: 20 · 2025: 42 · 2024: 46 · 2023: 38 · 2022: 30 · 2021: 13 · 2020: 1
FWCI
1.58
Type
journal article
Language
en
Open access
closed
Locations
  • Natural Product Reports (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Natural Science Foundation of China (31870668)
  • China Agricultural Research System (CARS-21)
  • National Key Research and Development Program of China (2018YFC1706400)
Topics
  • Physical Sciences › Chemistry › Organic Chemistry › Wood and Agarwood Research
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Natural Compound Pharmacology Studies
  • Health Sciences › Medicine › Pharmacology › Pharmacological Effects of Medicinal Plants
Keywords
agarwood, Aquilaria, sesquiterpenes, chemical constituents, biological activity, biosynthesis, natural products, xanthones, flavonoids, diterpenoids, medicinal properties, incense
MeSH terms
Alkaloids, Animals, Anti-Inflammatory Agents, Non-Steroidal, Anti-Bacterial Agents, Biological Products, Flavonoids, Humans, Hypoglycemic Agents, Phenols, Sesquiterpenes, Wood, Thymelaeaceae

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