Natural products in agarwood and Aquilaria plants: chemistry, biological activities and biosynthesis
Abstract
Covering: Up to the end of 2019.Agarwood is a resinous portion of Aquilaria trees, which is formed in response to environmental stress factors such as physical injury or microbial attack. It is very sought-after among the natural incenses, as well as for its medicinal properties in traditional Chinese and Ayurvedic medicine. Interestingly, the chemical constituents of agarwood and healthy Aquilaria trees are quite different. Sesquiterpenes and 2-(2-phenethyl)chromones with diverse scaffolds commonly accumulate in agarwood. Similar structures have rarely been reported from the original trees that mainly contain flavonoids, benzophenones, xanthones, lignans, simple phenolic compounds, megastigmanes, diterpenoids, triterpenoids, steroids, alkaloids, etc. This review summarizes the chemical constituents and biological activities both in agarwood and Aquilaria trees, and their biosynthesis is discussed in order to give a comprehensive overview of the research progress on agarwood.
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The metabolism, bioavailability, and biological activity of flavonoids depend upon the configuration, total number of hydroxyl groups, and substitution of functional groups about their nuclear structure.
“For example, the metabolism, bioavailability, and biological activity of flavonoids depend upon the configuration, total number of hydroxyl groups, and substitution of functional groups about their nuclear structure [109].”
From Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy (2021) · cites this paper as [109]
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Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy
Wang, Y., Liu, Q., Quan, H., Kang, S.-G., Huang, K., & Tong, T. (2021) · Nutrients · doi:10.3390/nu13061914 · Cited by 61 · see citing works
- Authors
- Li, W., Chen, H.-Q., Wang, H., Mei, W.-L., & Dai, H.-F.
- Affiliations
- Chinese Academy of Tropical Agricultural Sciences (CN)
- Hainan Engineering Research Center of Agarwood
- Corresponding author
- Mei, Wen-Li
- Dai, Hao-Fu
- Venue
- Natural Product Reports
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2021
- Volume
- 38
- Issue
- 3
- Pages
- 528-565
- ISSN
- 0265-0568 (ISSN-L)
- 1460-4752
- OpenAlex
- W3089852545
- Cited by
- 190
- References
- 197
- Citations by year
- 2026: 20 · 2025: 42 · 2024: 46 · 2023: 38 · 2022: 30 · 2021: 13 · 2020: 1
- FWCI
- 1.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Natural Product Reports (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (31870668)
- China Agricultural Research System (CARS-21)
- National Key Research and Development Program of China (2018YFC1706400)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Wood and Agarwood Research
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Natural Compound Pharmacology Studies
- Health Sciences › Medicine › Pharmacology › Pharmacological Effects of Medicinal Plants
- Keywords
- agarwood, Aquilaria, sesquiterpenes, chemical constituents, biological activity, biosynthesis, natural products, xanthones, flavonoids, diterpenoids, medicinal properties, incense
- MeSH terms
- Alkaloids, Animals, Anti-Inflammatory Agents, Non-Steroidal, Anti-Bacterial Agents, Biological Products, Flavonoids, Humans, Hypoglycemic Agents, Phenols, Sesquiterpenes, Wood, Thymelaeaceae
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