Association between Maternal Vitamin D Levels and Risk of Adverse Pregnancy Outcomes: A Systematic Review and Dose-Response Meta-Analysis
Abstract
= 0.009). Our meta-analysis provides further scientific evidence of the inverse association between 25(OH)D levels and the risk of GDM, PE, and GH, which may be useful for the prevention of pregnancy complications. However, more evidence from prospective studies is needed regarding the dietary intake of vitamin D during pregnancy.
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Several observational studies have found that insufficient vitamin D status is associated with a higher risk of insulin resistance and the development of GDM, suggesting that low serum 25-hydroxyvitamin D may be an independent risk factor for impaired glucose metabolism during pregnancy.
“Several observational studies have also found that insufficient vitamin D status is associated with a higher risk of insulin resistance and the development of GDM, suggesting that low serum 25-hydroxyvitamin D may be an independent risk factor for impaired glucose metabolism during pregnancy [147,148].”
From Maternal Overnutrition and Fetal Programming: Long-Term Metabolic, Cognitive, and Epigenetic Consequences (2026) · cites this paper as [148]
Cites
Boyle, V. T., Thorstensen, E. B., Mourath, D., Jones, M. B., McCowan, L. M. E., Kenny, L. C., & Baker, P. N. (2016) · British Journal of Nutrition · doi:10.1017/s0007114516003202 · Cited by 82 · see citing works
Milajerdi, A., Abbasi, F., Mousavi, S. M., & Esmaillzadeh, A. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2021.03.037 · Cited by 64 · see citing works
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Schiera, G., Macajone, G., Volpes, S., Greco, L., Di Liegro, C. M., Serio, G., Caradonna, F., & Naselli, F. (2026) · Cells · doi:10.3390/cells15040366 · Cited by 8 · see citing works
- Authors
- Zhao, R., Zhou, L., Wang, S., Xiong, G., & Hao, L.
- Affiliations
- Huazhong University of Science and Technology (CN)
- Central Hospital of Wuhan (CN)
- Corresponding author
- Hao, Liping
- Venue
- Food & Function
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2022
- Volume
- 13
- Issue
- 1
- Pages
- 14-37
- ISSN
- 2042-6496 (ISSN-L)
- 2042-650X
- OpenAlex
- W3216840938
- Cited by
- 23
- References
- 2
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 4 · 2023: 3 · 2022: 6
- FWCI
- 0.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Food & Function (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81773426, 82173513)
- Health Commission of Hubei Province (WJ2021F003)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Keywords
- maternal vitamin D, 25-hydroxyvitamin D, adverse pregnancy outcomes, gestational diabetes mellitus, preeclampsia, gestational hypertension, dose-response relationship, pregnancy complications, vitamin D supplementation
- MeSH terms
- Adult, Cesarean Section, Female, Humans, Pregnancy, Pregnancy Outcome, Vitamin D, Diabetes, Gestational, Hypertension, Pregnancy-Induced, Young Adult
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