pH-Responsive size-shrinkable mesoporous silica-based nanocarriers for improving tumor penetration and therapeutic efficacy

In the citing paper

“Second, ultra-shrinkage to sub-10 ~ 20 nm fragments is most effective at overcoming ECM and IFP bottlenecks in stroma-rich tumors [22].”

In the citing paper

“In comparative terms, acid/GSH shrinkers emphasize interstitial passage and retention with relatively simple chemistries [22, 23], whereas protease-directed ultra-shrinkers are especially potent in desmoplastic matrices that overexpress MMPs, achieving deeper spread at the cost of more elaborate trigger design.”

In the citing paper

“First, modest contraction, approximately twofold, already reduces steric hindrance and improves interstitial diffusion.”

In the citing paper

“Because activated fragments are often neutral to mildly negative, diffusion gains can outpace cellular entry, which encourages coupling shrinkage with a second lever such as latent cation exposure or ligand unmasking so that transport is not achieved at the expense of uptake [22, 24].”

In the citing paper

“When shrinkers are combined with prior microenvironment priming, for example brief courses that lower IFP or soften ECM, the same activated size window, about 20–50 nm, tends to produce more uniform coverage than without priming.”

In the citing paper

“In addition, when the activated entities approach the ultrasmall range, concentration gradients can drive partial back-diffusion toward vessels, and systemic elimination can accelerate once fragments re-enter circulation, collectively increasing the risk of intratumoral washout.”