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pH-Responsive size-shrinkable mesoporous silica-based nanocarriers for improving tumor penetration and therapeutic efficacy
Abstract
To overcome the nanomedicine penetration barrier across the dense tumor matrix, acidic tumor microenvironment-responsive size-shrinkable mesoporous silica-based nanomedicine is developed for enhancing drug tumor penetration and therapeutic efficacy.
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In the citing paper
“Second, ultra-shrinkage to sub-10 ~ 20 nm fragments is most effective at overcoming ECM and IFP bottlenecks in stroma-rich tumors [22].”
From Overcoming tumor microenvironment barriers: transformable and bioinspired nanomedicine strategies for deep tumor penetration (2026) · cites this paper as [22]
In the citing paper
“In comparative terms, acid/GSH shrinkers emphasize interstitial passage and retention with relatively simple chemistries [22, 23], whereas protease-directed ultra-shrinkers are especially potent in desmoplastic matrices that overexpress MMPs, achieving deeper spread at the cost of more elaborate trigger design.”
From Overcoming tumor microenvironment barriers: transformable and bioinspired nanomedicine strategies for deep tumor penetration (2026) · cites this paper as [22]
In the citing paper
“First, modest contraction, approximately twofold, already reduces steric hindrance and improves interstitial diffusion.”
From Overcoming tumor microenvironment barriers: transformable and bioinspired nanomedicine strategies for deep tumor penetration (2026) · cites this paper as [22]
In the citing paper
“Because activated fragments are often neutral to mildly negative, diffusion gains can outpace cellular entry, which encourages coupling shrinkage with a second lever such as latent cation exposure or ligand unmasking so that transport is not achieved at the expense of uptake [22, 24].”
From Overcoming tumor microenvironment barriers: transformable and bioinspired nanomedicine strategies for deep tumor penetration (2026) · cites this paper as [22]
In the citing paper
“When shrinkers are combined with prior microenvironment priming, for example brief courses that lower IFP or soften ECM, the same activated size window, about 20–50 nm, tends to produce more uniform coverage than without priming.”
From Overcoming tumor microenvironment barriers: transformable and bioinspired nanomedicine strategies for deep tumor penetration (2026) · cites this paper as [22]
In the citing paper
“In addition, when the activated entities approach the ultrasmall range, concentration gradients can drive partial back-diffusion toward vessels, and systemic elimination can accelerate once fragments re-enter circulation, collectively increasing the risk of intratumoral washout.”
From Overcoming tumor microenvironment barriers: transformable and bioinspired nanomedicine strategies for deep tumor penetration (2026) · cites this paper as [22]
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Cited by
Sorted by citations
Sheng, J., Yuan, W., Zhang, M., Chen, Z., Qi, Y., Zhao, Y., & Zhang, S. (2026) · Journal of Nanobiotechnology · doi:10.1186/s12951-026-04028-7 · Cited by 35
Metadata
- Authors
- He, Y., Fan, X., Wu, X., Hu, T., Zhou, F., Tan, S., Chen, B., Pan, A., Liang, S., & Xu, H.
- Venue
- Nanoscale
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2022
- Volume
- 14
- Issue
- 4
- Pages
- 1271-1284
- ISSN
- 2040-3364
- 2040-3372
- Cited by
- 22
- References
- 0
- Language
- en
- Funders
- Natural Science Foundation of Hunan Province (2020JJ5699)
- National Natural Science Foundation of China (82001942)
- Fundamental Research Funds for the Central Universities (10500-202045010)
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- This page
- CoChat. (2026). Citation check: pH-Responsive size-shrinkable mesoporous silica-based nanocarriers for improving tumor penetration and therapeutic efficacy. https://app.cochat.ai/papers/10.1039/d1nr07513f
- The paper
- He, Y., Fan, X., Wu, X., Hu, T., Zhou, F., Tan, S., Chen, B., Pan, A., Liang, S., & Xu, H. (2022). pH-Responsive size-shrinkable mesoporous silica-based nanocarriers for improving tumor penetration and therapeutic efficacy. Nanoscale. https://doi.org/10.1039/d1nr07513f
