Autophagy and evasion of the immune system by SARS-CoV-2. Structural features of the non-structural protein 6 from wild type and Omicron viral strains interacting with a model lipid bilayer
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Abstract
The viral cycle of SARS-CoV-2 is based on a complex interplay with the cellular machinery, which is mediated by specific proteins eluding or hijacking the cellular defense mechanisms.
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Cites
Highly accurate protein structure prediction with AlphaFold
Jumper, J., Evans, R., Pritzel, A., Green, T., Figurnov, M., Ronneberger, O., Tunyasuvunakool, K., Bates, R., Žídek, A., Potapenko, A., et al. (2021) · Nature · doi:10.1038/s41586-021-03819-2 · Cited by 43,764 · see citing works
Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine
Polack, F. P., Thomas, S. J., Kitchin, N., Absalon, J., Gurtman, A., Lockhart, S., Perez, J. L., Pérez Marc, G., Moreira, E. D., Zerbini, C., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2034577 · Cited by 14,592 · see citing works
Increased risk of SARS-CoV-2 reinfection associated with emergence of Omicron in South Africa
Pulliam, J. R. C., van Schalkwyk, C., Govender, N., Gottberg, A. V., Cohen, C., Groome, M. J., Dushoff, J., Mlisana, K., & Moultrie, H. (2021) · doi:10.1101/2021.11.11.21266068 · Cited by 1,037 · see citing works
Evasion of Type I Interferon by SARS-CoV-2
Xia, H., Cao, Z., Xie, X., Zhang, X., Chen, J. Y.-C., Wang, H., Menachery, V. D., Rajsbaum, R., & Shi, P.-Y. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108234 · Cited by 957 · see citing works
Immunological mechanisms of vaccine-induced protection against COVID-19 in humans
Sadarangani, M., Marchant, A., & Kollmann, T. R. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-021-00578-z · Cited by 560 · see citing works
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- Authors
- Bignon, E., Marazzi, M., Grandemange, S., & Monari, A.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Universidad de Alcalá (ES)
- Corresponding author
- Bignon, Emmanuelle
- Marazzi, Marco
- Monari, Antonio
- Venue
- Chemical Science
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2022
- Volume
- 13
- Issue
- 20
- Pages
- 6098-6105
- ISSN
- 2041-6520 (ISSN-L)
- 2041-6539
- PMC
- PMC9132136
- OpenAlex
- W4282922850
- Cited by
- 13
- References
- 5
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 5 · 2022: 3
- FWCI
- 1.59
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Chemical Science (publishedVersion, cc-by)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion, cc-by)
- Funders
- Ministère de l'Enseignement supérieur, de la Recherche et de l'Innovation
- Agence Nationale de la Recherche (ANR 11 LABX 086, ANR 11 IDEX 05 02)
- Universidad de Alcalá
- Comunidad de Madrid
- Centre National de la Recherche Scientifique
- Commissariat Général à l'Investissement
- European Commission
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
- Keywords
- SARS-CoV-2, Omicron variant, NSP6, autophagy evasion, endoplasmic reticulum membrane, lipid bilayer interaction, protein-lipid interactions, viral immune evasion, long-timescale molecular dynamics
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