Protein quaternary structures in solution are a mixture of multiple forms
Open accessPublished version of a preprint
Abstract
Comparing the different methods for determining oligomerization composition of a protein in solution at different concentrations. The ruler of μg ml −1 represents protein concentrations applicable for the different methods.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Highly accurate protein structure prediction with AlphaFold
Jumper, J., Evans, R., Pritzel, A., Green, T., Figurnov, M., Ronneberger, O., Tunyasuvunakool, K., Bates, R., Žídek, A., Potapenko, A., et al. (2021) · Nature · doi:10.1038/s41586-021-03819-2 · Cited by 43,764 · see citing works
ColabFold - Making protein folding accessible to all
Mirdita, M., Schütze, K., Moriwaki, Y., Heo, L., Ovchinnikov, S., & Steinegger, M. (2021) · doi:10.1101/2021.08.15.456425 · Cited by 9,391 · see citing works
Protein complex prediction with AlphaFold-Multimer
Evans, R., O’Neill, M., Pritzel, A., Antropova, N., Senior, A., Green, T., Žídek, A., Bates, R., Blackwell, S., Yim, J., et al. (2021) · doi:10.1101/2021.10.04.463034 · Cited by 3,808 · see citing works
Announcing the worldwide Protein Data Bank
Berman, H., Henrick, K., & Nakamura, H. (2003) · Nature Structural & Molecular Biology · doi:10.1038/nsb1203-980 · Cited by 3,093 · see citing works
VanAernum, Z. L., Busch, F., Jones, B. J., Jia, M., Chen, Z., Boyken, S. E., Sahasrabuddhe, A., Baker, D., & Wysocki, V. H. (2020) · Nature Protocols · doi:10.1038/s41596-019-0281-0 · Cited by 169 · see citing works
Self-citationA hydrophobic ratchet entrenches molecular complexes
Hochberg, G. K. A., Liu, Y., Marklund, E. G., Metzger, B. P. H., Laganowsky, A., & Thornton, J. W. (2020) · Nature · doi:10.1038/s41586-020-3021-2 · Cited by 134 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
An atlas of protein homo-oligomerization across domains of life
Schweke, H., Pacesa, M., Levin, T., Goverde, C. A., Kumar, P., Duhoo, Y., Dornfeld, L. J., Dubreuil, B., Georgeon, S., Ovchinnikov, S., et al. (2024) · Cell · doi:10.1016/j.cell.2024.01.022 · Cited by 144 · see citing works
- Authors
- Marciano, S., Dey, D., Listov, D., Fleishman, S. J., Sonn-Segev, A., Mertens, H., Busch, F., Kim, Y., Harvey, S. R., Wysocki, V. H., & Schreiber, G.
- Affiliations
- Weizmann Institute of Science (IL)
- Refeyn Ltd, 1 Electric Avenue, Ferry Hinksey Road, Oxford OX2 0BY, UK
- European Molecular Biology Laboratory (DE)
- Department of Chemistry and Biochemistry, Resource for Native Mass Spectrometry Guided Structural Biology, The Ohio State University, Columbus, OH, 43210, USA
- The Ohio State University (US)
- Corresponding author
- Schreiber, Gideon
- ORCID
- Venue
- Chemical Science
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2022
- Volume
- 13
- Issue
- 39
- Pages
- 11680-11695
- ISSN
- 2041-6520 (ISSN-L)
- 2041-6539
- PMC
- PMC9555727
- OpenAlex
- W4296695943
- Cited by
- 41
- References
- 6
- Citations by year
- 2026: 7 · 2025: 10 · 2024: 16 · 2023: 6 · 2022: 2
- FWCI
- 2.94
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Chemical Science (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Israel Science Foundation (1268/18)
- National Institutes of Health (NIH P41 GM128577)
- Horizon 2020 (653706)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
- Physical Sciences › Materials Science › Materials Chemistry › Enzyme Structure and Function
- Physical Sciences › Chemistry › Spectroscopy › Mass Spectrometry Techniques and Applications
- Keywords
- quaternary structure, oligomeric state, bacterial proteins, homo-oligomers, hetero-oligomers, AlphaFold-Multimer
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
