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Cited by 12Virus-based gene therapy researchBacteriophages and microbial interactionsNanoparticle-Based Drug Delivery

Bacteriophage-based particles carrying the TNF-related apoptosis-inducing ligand (TRAIL) gene for targeted delivery in hepatocellular carcinoma

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Sittiju, Pattaralawan, Wudtiwai, Benjawan, Chongchai, Aitthiphon, Hajitou, Amin, Kongtawelert, Prachya, Pothacharoen, Peraphan, Suwan, Keittisak·2024·Nanoscale
DOI 10.1039/d3nr05660kPMC PMC10977282
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Abstract

The TRAIL (Tumour Necrosis Factor-Related Apoptosis-Inducing Ligand) is a promising candidate for cancer treatment due to its unique ability to selectively induce programmed cell death, or apoptosis, in cancer cells while sparing healthy ones.

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  • Advanced synthetic biology approaches enable incorporation of complex genetic circuits and therapeutic genes into phages.

    “Advanced synthetic biology approaches enable the incorporation of complex genetic circuits and therapeutic genes [15,76,87–89]”

    From Phage therapy in oncology: opportunities for cancer prevention and treatment (2026) · cites this paper as [88]

    The Experimental section (page not provided) describes engineering a phage-based particle to carry a cassette containing the therapeutic TRAIL gene. The Discussion also describes phage genetic material as customizable. Neither section describes incorporating complex genetic circuits, so the paper supports only the therapeutic-gene part of the claim. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

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Cited by

Sorted by citations

Authors
Sittiju, P., Wudtiwai, B., Chongchai, A., Hajitou, A., Kongtawelert, P., Pothacharoen, P., & Suwan, K.
Affiliations
  • Imperial College London (GB)
  • Chiang Mai University (TH)
Corresponding author
  • Pothacharoen, Peraphan
  • Suwan, Keittisak
ORCID
Venue
Nanoscale
Publisher
Royal Society of Chemistry (RSC)
Published
2024
Volume
16
Issue
13
Pages
6603-6617
ISSN
  • 2040-3364 (ISSN-L)
  • 2040-3372
DOI
10.1039/d3nr05660k
PMC
PMC10977282
OpenAlex
W4392113523
Cited by
12
References
2
Citations by year
2026: 7 · 2025: 3 · 2024: 2
FWCI
3.17
Type
journal article
Language
en
Open access
Licence
Locations
  • Nanoscale (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • PubMed Central (publishedVersion, cc-by)
Funders
  • Royal Golden Jubilee (RGJ) Ph.D. Programme (PHD/0191/2559)
  • Medical Research Council (G0701159, MR/T029226/1)
  • CHILDREN with CANCER UK (13/147, 16/230)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
  • Physical Sciences › Environmental Science › Ecology › Bacteriophages and microbial interactions
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Keywords
TRAIL, hepatocellular carcinoma, targeted gene delivery, gene therapy, apoptosis, phage display
MeSH terms
Bacteriophages, Carcinoma, Hepatocellular, Humans, Ligands, Liver Neoplasms, Genetic Therapy, Apoptosis, Cell Line, Tumor, Receptors, TNF-Related Apoptosis-Inducing Ligand, TNF-Related Apoptosis-Inducing Ligand

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