Biomimetic polymeric transcatheter heart valve leaflets with low calcification and good regenerative ability
Abstract
Transcatheter aortic valve replacement (TAVR) technology is quickly advancing in clinic, however, as it expands to low-risk populations and younger patients (age <65 years), device durability is becoming a major challenge.
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Biomimetic composite scaffold of PLCL, gelatin, hyaluronic acid, and fibroin proteins has appropriate mechanical strength, low calcification deposition and good regenerative ability in rat subcutaneous implantation.
“The results of subcutaneous implantation in rats showed that the biomimetic composite scaffold had appropriate mechanical strength, low calcification deposition and good regenerative ability [175].”
From Application of PLCL as a biodegradable polymer in biomedical engineering (2026) · cites this paper as [175]
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References 33 · Cited by 7
- Authors
- Wang, X., Jiang, H., Zhang, W., Kong, Y., Kong, D., Liu, J., & Wang, Z.
- Affiliations
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Tianjin Center for Medical Device Evaluation and Inspection, Tianjin, China
- Corresponding author
- Kong, Deling
- Liu, Jing
- Wang, Zhihong
- Venue
- Journal of Materials Chemistry B
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2023
- Volume
- 11
- Issue
- 25
- Pages
- 5805-5816
- ISSN
- 2050-750X (ISSN-L)
- 2050-7518
- OpenAlex
- W4379377054
- Cited by
- 7
- References
- 33
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3
- FWCI
- 1.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Materials Chemistry B (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (32071356, 82272158)
- Science Fund for Distinguished Young Scholars of Tianjin (22JCJQJC00110)
- Fundamental Research Funds for the Central Universities (3332022069)
- Topics
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Valve Diseases and Treatments
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Keywords
- hydroxyapatite, calcification resistance, tissue regeneration, angiogenesis, cell infiltration, mechanical strength, polymeric biomaterials
- MeSH terms
- Animals, Aortic Valve, Aortic Valve Stenosis, Calcinosis, Cells, Cultured, Polymers, Tissue Engineering, Biomimetics, Rats
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