Thermodynamic and spectroscopic study of copper( II )–glycyl- L -histidylglycine complexes in aqueous solution
Abstract
The complexes formed in aqueous solution by copper(II) with glycyl-L-histidylglycine (L–) have been extensively studied, by using potentiometry, calorimetry, visible spectrophotometry and circular dichroism techniques, with the aim of elucidating their type and probable structure. Only monomeric species are formed in the acidic range of pH ([CuL]+, [CuLH–1], [CuL2] and [CuL2H–1]–), while at higher pH (>8) polynuclear [Cu4L4H–6]4– is formed in addition to [CuLH–2]–. The interpretation of all the experimental data is strongly consistent with a structure involving three nitrogen atoms co-ordinated to copper(II) for [CuLH–1] and [CuL]+ and with the participation of a fourth nitrogen atom in [CuLH–2]– and [Cu4L4H–8]4–. In the tetrameric species very probably there is a dissociation of the N(1)-pyrrole hydrogen ion, with consequent formation of imidazolate bridges.
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The assignment of the deprotonation to a water molecule instead of an imidazole N1 from another Cu(GHK) complex is rationalized by the lack of drastic changes of CD parameters expected upon formation of imidazole-bridged dimeric or tetrameric species.
“The aforementioned assignment of the deprotonation to a water molecule instead of an imidazole N1 from another Cu(GHK) complex (with concomitant polynuclear species formation) is rationalized by the lack of drastic changes of CD parameters that would be expected upon formation of imidazole-bridged dimeric or tetrameric species [21,22,23].”
From Ternary Cu(II) Complex with GHK Peptide and Cis-Urocanic Acid as a Potential Physiologically Functional Copper Chelate (2020) · cites this paper as [23]
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- Authors
- Daniele, P. G., Zerbinati, O., Zelano, V., & Ostacoli, G.
- Venue
- J. Chem. Soc., Dalton Trans.
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 1991
- Issue
- 10
- Pages
- 2711-2715
- ISSN
- 1364-5447 (ISSN-L)
- 0300-9246
- OpenAlex
- W2168119268
- Cited by
- 49
- References
- 15
- Citations by year
- 2026: 1 · 2022: 2 · 2021: 1 · 2020: 3 · 2019: 3 · 2018: 6 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 4 · 2012: 1
- FWCI
- 0.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the Chemical Society Dalton Transactions (publishedVersion)
- Funders
- Consiglio Nazionale delle Ricerche
- Topics
- Health Sciences › Medicine › Oncology › Metal complexes synthesis and properties
- Physical Sciences › Chemical Engineering › Filtration and Separation › Chemical and Physical Properties in Aqueous Solutions
- Physical Sciences › Chemistry › Organic Chemistry › Inorganic and Organometallic Chemistry
- Keywords
- copper(II) complexes, coordination chemistry, polynuclear copper complexes, complex stoichiometry, pH dependence, aqueous solutions, circular dichroism, potentiometric titration, calorimetry, visible spectrophotometry
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