Fe III -ion-catalysed non-enzymatic transformation of ADP in to ATP
Abstract
Non-enzymatic phosphorylation of ADP to ATP has been found to occur readily when FeIII ion is present in aqueous solutiond of ADP and acetyl phosphate. As long as the reaction temperature is low enough (25 °C or less), the phosphorylation of ADP to ATP proceeds to about 20% conversion with 100% selectivity. At higher temperatures, the yield decreases owing to the hydrolysis of acetyl phosphate. Among several phosphoryl donors studies, acetyl phosphate was found to be the best phosphorylating reagent. Creatine phosphate also produced ATP but the efficiency was very low. The phosphorylation of AMP was unsuccessful, even with acetyl phosphate.
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Acyl phosphates can phosphorylate ADP without enzymes.
“it has long been known that acyl phosphates can phosphorylate ADP without enzymes (Kitani et al., 1991).”
From Serpentinization as the source of energy, electrons, organics, catalysts, nutrients and pH gradients for the origin of LUCA and life (2023) · cites this paper as Kitani et al., 1991
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Electrochemical Cells Conducting Mitochondorial Oxidative Phosphorylation and NADH Oxidation
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Frank, A. W. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-407194-0.00005-6 · Cited by 1 · see citing works
(2013) · Elsevier eBooks · doi:10.1016/b978-0-12-407194-0.09996-0
- Authors
- Kitani, A., Tsunetsugu, S.-I., & Sasaki, K.
- ORCID
- Sasaki, Kazuo
- Venue
- Journal of the Chemical Society, Perkin Transactions 2
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 1991
- Issue
- 3
- Pages
- 329
- ISSN
- 0300-9580 (ISSN-L)
- 1364-5471
- OpenAlex
- W2006818359
- Cited by
- 14
- References
- 1
- Citations by year
- 2023: 4 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 1 · 2013: 2
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the Chemical Society Perkin Transactions 2 (publishedVersion)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Chemical Reaction Mechanisms
- Physical Sciences › Chemistry › Organic Chemistry › Organophosphorus compounds synthesis
- Physical Sciences › Chemistry › Organic Chemistry › Inorganic and Organometallic Chemistry
- Keywords
- ADP phosphorylation, iron(III) catalysis, acetyl phosphate, phosphocreatine, temperature dependence, nucleotide synthesis
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