A conserved RGD (Arg-Gly-Asp) motif in the transferrin receptor is required for binding to transferrin
Open accessAbstract
The transferrin receptor contains a highly conserved Arg-Gly-Asp (RGD) sequence in the C-terminal region where transferrin is thought to bind. RGD sequences are commonly involved in cell adhesion. This sequence is crucial for transferrin binding, suggesting possible evolutionary links between molecules mediating iron uptake and cell adhesion.
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A correlation between the length of the GAA repeat and deficiency of frataxin along with severity or onset of FRDA symptoms has been observed.
“A correlation between the length of the GAA repeat and deficiency of frataxin along with severity or onset of FRDA symptoms have been observed (76).”
From Intracellular iron transport and storage: from molecular mechanisms to health implications (2008) · cites this paper as [76]
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RGD AND OTHER RECOGNITION SEQUENCES FOR INTEGRINS
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Leucocyte typing VI : white cell differentiation antigens
Kishimoto, T. (1998) · Cited by 187 · see citing works
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Chemistry and biology of eukaryotic iron metabolism
Aisen, P. (2001) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(01)00063-2 · Cited by 804 · see citing works
Structure of the human transferrin receptor-transferrin complex
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Intracellular iron transport and storage: from molecular mechanisms to health implications
Mackenzie, E. L., Iwasaki, K., & Tsuji, Y. (2008) · Antioxidants & Redox Signaling · doi:10.1089/ars.2007.1893 · Cited by 526 · see citing works
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Mechanism for Multiple Ligand Recognition by the Human Transferrin Receptor
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- Authors
- DUBLJEVIC, V., SALI, A., & GODING, J. W.
- Affiliations
- The Alfred Hospital (AU)
- ORCID
- DUBLJEVIC, Valentina
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 1999-06-24
- Volume
- 341
- Issue
- 1
- Pages
- 11-14
- ISSN
- 0264-6021 (ISSN-L)
- 1470-8728
- PMC
- PMC1220324
- OpenAlex
- W1987489188
- Cited by
- 63
- References
- 3
- Citations by year
- 2025: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 3 · 2016: 2 · 2015: 1 · 2013: 4 · 2012: 3
- FWCI
- 2.69
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Biochemical Journal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Keywords
- transferrin receptor, RGD motif, Arg-Gly-Asp sequence, transferrin binding, iron absorption, cell adhesion, C-terminal region, protein-protein interaction
- MeSH terms
- Alkaline Phosphatase, Amino Acid Sequence, Humans, Molecular Sequence Data, Oligopeptides, Protein Binding, Receptors, Transferrin, Recombinant Fusion Proteins, Transferrin, Conserved Sequence, Sequence Homology, Amino Acid
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