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Repression of gene expression by oxidative stress
Open accessAbstract
Gene expression is modulated by both physiological signals (hormones, cytokines, etc.) and environmental stimuli (physical parameters, xenobiotics, etc.). Oxidative stress appears to be a key pleiotropic modulator which may be involved in either pathway. Indeed, reactive oxygen species (ROS) have been described as second messengers for several growth factors and cytokines, but have also been shown to rise following cellular insults such as xenobiotic metabolism or enzymic deficiency. Extensive studies on the induction of stress-response genes by oxidative stress have been reported. In contrast, owing to the historical focus on gene induction, less attention has been paid to gene repression by ROS. However, a growing number of studies have shown that moderate (i.e. non-cytotoxic) oxidative stress specifically down-regulates the expression of various genes. In this review, we describe the alteration of several physiological functions resulting from oxidative-stress-mediated inhibition of gene transcription. We will then focus on the repressive oxidative modulation of various transcription factors elicited by ROS.
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Cites
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Mitochondrial reactive oxygen species trigger hypoxia-induced transcription
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Redox Regulation of Fos and Jun DNA-Binding Activity in Vitro
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Role for NF-κB in the regulation of ferritin H by tumor necrosis factor-α
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Cited by
Nordberg, J., & Arnér, E. S. J. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00724-9 · Cited by 2,662
The Haber–Weiss reaction and mechanisms of toxicity
Kehrer, J. P. (2000) · Toxicology · doi:10.1016/s0300-483x(00)00231-6 · Cited by 1,418
Role of Glutathione in Cancer Progression and Chemoresistance
Traverso, N., Ricciarelli, R., Nitti, M., Marengo, B., Furfaro, A. L., Pronzato, M. A., Marinari, U. M., & Domenicotti, C. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/972913 · Cited by 1,208
Glutathione in Cancer Biology and Therapy
Estrela, J. M., Ortega, A., & Obrador, E. (2006) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408360500523878 · Cited by 1,041
Oxidative pathways of chemical toxicity and oxidative stress biomarkers in marine organisms
Regoli, F., & Giuliani, M. E. (2014) · Marine Environmental Research · doi:10.1016/j.marenvres.2013.07.006 · Cited by 982
Metadata
- Authors
- Morel, Y., & Barouki, R.
- Venue
- Biochemical Journal
- Publisher
- Portland Press
- Published
- 1999-09-05
- Volume
- 342
- Issue
- 3
- Pages
- 481-481
- ISSN
- 0264-6021 (ISSN-L)
- OpenAlex
- W2045338351
- Cited by
- 542
- References
- 6
- FWCI
- 9.13
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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