Cited by 1,208Glutathione Transferases and PolymorphismsSulfur Compounds in BiologyRedox biology and oxidative stress

Role of Glutathione in Cancer Progression and Chemoresistance

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Traverso, Nicola, Ricciarelli, Roberta, Nitti, Mariapaola, Marengo, Barbara, Furfaro, Anna Lisa, Pronzato, Maria Adelaide, Marinari, Umberto Maria, Domenicotti, Cinzia·2013·Oxidative Medicine and Cellular Longevity

Abstract

Glutathione (GSH) plays an important role in a multitude of cellular processes, including cell differentiation, proliferation, and apoptosis, and disturbances in GSH homeostasis are involved in the etiology and progression of many human diseases including cancer. While GSH deficiency, or a decrease in the GSH/glutathione disulphide (GSSG) ratio, leads to an increased susceptibility to oxidative stress implicated in the progression of cancer, elevated GSH levels increase the antioxidant capacity and the resistance to oxidative stress as observed in many cancer cells. The present review highlights the role of GSH and related cytoprotective effects in the susceptibility to carcinogenesis and in the sensitivity of tumors to the cytotoxic effects of anticancer agents.

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Crossref · 10.1155/2013/972913

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  • GSH deficiency is related to the onset and progression of several diseases, including cancer, immunodeficiencies, seizures, neurodegeneration, cardiovascular dysfunctions, and diabetes.

    “A GSH deficiency has been related to the onset and progression of several diseases, including cancer, immunodeficiencies, seizures, neurodegeneration, cardiovascular dysfunctions, and diabetes [178,179,180].”

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Authors
Traverso, N., Ricciarelli, R., Nitti, M., Marengo, B., Furfaro, A. L., Pronzato, M. A., Marinari, U. M., & Domenicotti, C.
Affiliations
University of Genoa (IT)
Corresponding author
Domenicotti, Cinzia
Venue
Oxidative Medicine and Cellular Longevity
Publisher
Wiley
Published
2013
Volume
2013
Pages
1-10
ISSN
  • 1942-0994 (ISSN-L)
  • 1942-0900
OpenAlex
W2096258216
Cited by
1,208
References
126
Citations by year
2026: 81 · 2025: 95 · 2024: 92 · 2023: 135 · 2022: 130 · 2021: 139 · 2020: 130 · 2019: 100 · 2018: 80 · 2017: 82 · 2016: 70 · 2015: 42 · 2014: 25 · 2013: 7
FWCI
4.51
Type
journal article
Language
en
Open access
Locations
  • Oxidative Medicine and Cellular Longevity (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion)
Funders
  • Ministero dell’Istruzione, dell’Università e della Ricerca (2009M8FKBB_002)
  • Università degli Studi di Genova (2009M8FKBB_002)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glutathione Transferases and Polymorphisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Sulfur Compounds in Biology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords
glutathione, glutathione disulfide, tumor progression, chemoresistance, oxidative stress, antioxidant capacity, carcinogenesis, anticancer drug sensitivity, cytoprotection
MeSH terms
Animals, Glutathione, Humans, Neoplasms, Disease Progression, Drug Resistance, Neoplasm

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