The DOI matches its OpenAlex record; 15 of the 15 references it cites were found in a registry or an index.
Regulation of cytochrome P450 (CYP) genes by nuclear receptors
Open accessAbstract
Members of the nuclear-receptor superfamily mediate crucial physiological functions by regulating the synthesis of their target genes. Nuclear receptors are usually activated by ligand binding. Cytochrome P450 (CYP) isoforms often catalyse both formation and degradation of these ligands. CYPs also metabolize many exogenous compounds, some of which may act as activators of nuclear receptors and disruptors of endocrine and cellular homoeostasis. This review summarizes recent findings that indicate that major classes of CYP genes are selectively regulated by certain ligand-activated nuclear receptors, thus creating tightly controlled networks.
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Cites
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Cited by
The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity
Staudinger, J. L., Goodwin, B., Jones, S. A., Hawkins-Brown, D., MacKenzie, K. I., LaTour, A., Liu, Y., Klaassen, C. D., Brown, K. K., Reinhard, J., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051551698 · Cited by 1,379
Peroxisome Proliferator-Activated Receptor Alpha Target Genes
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Aryl hydrocarbon receptors: diversity and evolution
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Induction of Drug Metabolism: The Role of Nuclear Receptors
Handschin, C., & Meyer, U. A. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.4.2 · Cited by 470
Interindividual Variability in Inhibition and Induction of Cytochrome P450 Enzymes
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Metadata
- Authors
- Honkakoski, P., & Negishi, M.
- Venue
- Biochemical Journal
- Publisher
- Portland Press
- Published
- 2000-04-10
- Volume
- 347
- Issue
- 2
- Pages
- 321-321
- ISSN
- 0264-6021 (ISSN-L)
- OpenAlex
- W2081152882
- Cited by
- 501
- References
- 15
- FWCI
- 22.76
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
