The DOI matches its Crossref record; 119 of the 119 references it cites were found in a registry or an index.
Interindividual Variability in Inhibition and Induction of Cytochrome P450 Enzymes
Abstract
Drug interactions have always been a major concern in medicine for clinicians and patients. Inhibition and induction of cytochrome P450 (CYP) enzymes are probably the most common causes for documented drug interactions. Today, many pharmaceutical companies are predicting potential interactions of new drug candidates. Can in vivo drug interactions be predicted accurately from in vitro metabolic studies? Should the prediction be qualitative or quantitative? Although some scientists believe that quantitative prediction of drug interactions is possible, others are less optimistic and believe that quantitative prediction would be very difficult. There are many factors that contribute to our inability to quantitatively predict drug interactions. One of the major complicating factors is the large interindividual variability in response to enzyme inhibition and induction. This review examines the sources that are responsible for the interindividual variability in inhibition and induction of cytochrome P450 enzymes.
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Cytochrome P450 Enzymes and Drug Metabolism in Humans
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Inhibition of Human Cytochrome P450 Enzymes by Bacopa monnieri Standardized Extract and Constituents
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“the intestinal mucosa are the most important contributors in drug metabolism [16].”
Background
Metadata
- Authors
- Lin, J. H., & Lu, A. Y.
- Venue
- Annual Review of Pharmacology and Toxicology
- Publisher
- Annual Reviews
- Published
- 2001-04
- Volume
- 41
- Issue
- 1
- Pages
- 535-567
- ISSN
- 0362-1642 (ISSN-L)
- 1545-4304
- OpenAlex
- W2109257139
- Cited by
- 285
- References
- 119
- FWCI
- 0.94
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lin, J. H., & Lu, A. Y. (2001). Interindividual Variability in Inhibition and Induction of Cytochrome P450 Enzymes. Annual Review of Pharmacology and Toxicology. https://doi.org/10.1146/annurev.pharmtox.41.1.535
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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