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Non-mevalonate isoprenoid biosynthesis: enzymes, genes and inhibitors
Abstract
The essential steps of the novel non-mevalonate pathway of isopentenyl diphosphate and isoprenoid biosynthesis in plants are described. The first five enzymes and genes of this 1-deoxy-D-xylulose 5-phosphate/2-C-methyl-D-erythritol 4-phosphate (DOXP/MEP) pathway are known. The herbicide fosmidomycin specifically blocks the second enzyme, the DOXP reductoisomerase. The DOXP/MEP pathway is also present in several pathogenic bacteria and the malaria parasite. Hence, all herbicides and inhibitors blocking this novel isoprenoid pathway in plants are also potential drugs against malaria and diseases caused by pathogenic bacteria.
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Cited by
Peters, K. E., Walters, C. C., & Moldowan, J. M. (2004) · Cambridge University Press eBooks · doi:10.1017/cbo9780511524868 · Cited by 2,089
Lindberg, P., Park, S., & Melis, A. (2010) · Metabolic Engineering · doi:10.1016/j.ymben.2009.10.001 · Cited by 596
Terpenoid Metabolism in Wild-Type and Transgenic Arabidopsis Plants[W]
Aharoni, A., Giri, A. P., Deuerlein, S., Griepink, F., de Kogel, W.-J., Verstappen, F. W. A., Verhoeven, H. A., Jongsma, M. A., Schwab, W., & Bouwmeester, H. J. (2003) · The Plant Cell · doi:10.1105/tpc.016253 · Cited by 543
Zhong, J., Wang, Y., Chen, Z., Yalikun, Y., He, L., Liu, T., & Ma, G. (2024) · Biotechnology for Biofuels and Bioproducts · doi:10.1186/s13068-024-02555-9 · Cited by 25
Metadata
- Authors
- Lichtenthaler, H. K.
- Venue
- Biochemical Society Transactions
- Publisher
- Portland Press Ltd.
- Published
- 2000-12-01
- Volume
- 28
- Issue
- 6
- Pages
- 785
- ISSN
- 0300-5127 (ISSN-L)
- OpenAlex
- W1978843373
- Cited by
- 236
- References
- 0
- FWCI
- 2.14
- Type
- journal article
- Language
- en
- Open access
- closed
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