The DOI matches its Crossref record; 76 of the 76 references it cites were found in a registry or an index.
A tale of two Paks
Open accessAbstract
Paks (p21‐activated kinases) are effectors for the small GTPases Cdc42 (cell division cycle 42) and Rac that play fundamental roles in a wide range of cellular processes, including cell morphology, motility, survival, gene transcription, apoptosis and hormone signalling. These enzymes are widely expressed in numerous tissues and are activated by extracellular signals through GTPase‐dependent and ‐independent mechanisms. On the basis of structural and biochemical features, the Pak family members have been classified into two groups, comprising three members each. The two Pak groups have generally been considered as two halves of a single entity, but accumulating evidence indicates that this is not so. In this review, we discuss recent advances in our understanding of the structure, regulation and function of these kinases, emphasizing the many differences between these two groups of signalling proteins.
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Cites
Etienne-Manneville, S., & Hall, A. (2002) · Nature · doi:10.1038/nature01148 · Cited by 4,201
Patterns of somatic mutation in human cancer genomes
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A brain serine/threonine protein kinase activated by Cdc42 and Rac1
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Guanylyl Cyclases and Signaling by Cyclic GMP
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Biology of the p21-Activated Kinases
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Crystal Structure of the Catalytic Domains of Adenylyl Cyclase in a Complex with G sα ·GTPγS
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PAK Kinases Are Directly Coupled to the PIX Family of Nucleotide Exchange Factors
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Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells
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Self-citationExpression of Constitutively Active α-PAK Reveals Effects of the Kinase on Actin and Focal Complexes
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Structure of PAK1 in an Autoinhibited Conformation Reveals a Multistage Activation Switch
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Cited by
PAK signalling during the development and progression of cancer
Radu, M., Semenova, G., Kosoff, R., & Chernoff, J. (2014) · Nature Reviews Cancer · doi:10.1038/nrc3645 · Cited by 503
Self-citationSignaling networks of Rho GTPases in cell motility
Hanna, S., & El-Sibai, M. (2013) · Cellular Signalling · doi:10.1016/j.cellsig.2013.04.009 · Cited by 274
Guo, D., Yang, X., & Shi, L. (2020) · Cells · doi:10.3390/cells9040835 · Cited by 73
Nikolić, M. (2008) · Molecular Neurobiology · doi:10.1007/s12035-008-8032-1 · Cited by 56
Pak and Rac GTPases promote oncogenic KIT–induced neoplasms
Martin, H., Mali, R. S., Ma, P., Chatterjee, A., Ramdas, B., Sims, E., Munugalavadla, V., Ghosh, J., Mattingly, R. R., Visconte, V., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci67509 · Cited by 45
Metadata
- Authors
- Arias‐Romero, L. E., & Chernoff, J.
- Venue
- Biology of the Cell
- Publisher
- Wiley
- Published
- 2008-02
- Volume
- 100
- Issue
- 2
- Pages
- 97-108
- ISSN
- 0248-4900 (ISSN-L)
- 1768-322X
- OpenAlex
- W1973848203
- Cited by
- 364
- References
- 76
- FWCI
- 8.56
- Type
- journal article
- Language
- en
- Open access
- bronze
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