The effect of fumarate on the respiration of liver and kidney tissue
Open accessAbstract
THE interesting theory of Szent-Gy6rgyi and co-workers [Annau et al., 1935] that in respiration the system fumarate-oxaloacetate functions catalytically in transporting activated metabolite hydrogen to the cytochrome (Warburg-Keilin) system has received support in the experiments of Stare & Baumann [1936].Using the manometric method with pigeon breast muscle and heart muscle (swine), the latter investigators observed the following: "1.The oxygen uptake of tissues is increased by very small amounts of fumarate and the increase is much greater than can be accounted for by the oxidation of the fumarate itself.2. Small amounts of added fumarate are detectable after prolonged contact with respiring tissue.3. The increased respiration is normal, that is, the respiratory quotient is not materially changed by the addition of small amounts of fumarate.4. Substances which yield fumarate on contact with tissue-succinate, malate, oxaloacetate-show a similar action to fumarate itself."Recently Szent-Gy6rgyi and co-workers [Annau et at., 1936] have applied quantitative methods for the micro-estimation of oxaloacetic, pyruvic, and malic acids and have given additional evidence in support of their theory.They followed chemically the disappearance of oxaloacetic acid added to muscle and
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Stare and Baumann also found that added dicarboxylic acids were not used up and could still be detected in the medium, indicating they functioned catalytically.
“Significantly, they also found that added dicarboxylic acids were not used up and could still be detected in the medium, indicating that these compounds were functioning in a catalytic capacity (33).”
From Regulation and function of the mammalian tricarboxylic acid cycle (2023) · cites this paper as [33]
Stare and Baumann found that very small quantities of dicarboxylic acids were sufficient to cause an increase in oxygen consumption beyond what was necessary for oxidation of the quantities of substrate added.
“Support for this idea came the following year when Stare (33) and Baumann found that very small quantities of dicarboxylic acids were sufficient to cause an increase in oxygen consumption and that this increase was beyond what was necessary for the oxidation of the quantities of substrate added.”
From Regulation and function of the mammalian tricarboxylic acid cycle (2023) · cites this paper as [33]
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Regulation and function of the mammalian tricarboxylic acid cycle
Arnold, P. K., & Finley, L. W. S. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102838 · Cited by 535 · see citing works
“Support for this idea came the following year when Stare (33) and Baumann found that very small quantities of dicarboxylic acids were sufficient to cause an increase in oxygen consumption and that this increase was beyond what was necessary for the oxidation of the quantities of substrate added.”
BackgroundElliott, K. A. C., & Elliott, F. H. (1939) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)73798-8 · Cited by 18 · see citing works
Origins of the concept oxidative phosphorylation
Kalckar, H. Μ. (1974) · Molecular and Cellular Biochemistry · doi:10.1007/bf01874172 · Cited by 14 · see citing works
Locke, A., Locke, R. B., Schlesinger, H., et al. (1942) · Journal of the American Pharmaceutical Association (Scientific ed ) · doi:10.1002/jps.3030310103 · Cited by 14 · see citing works
Some effects of pyrophosphate on the metabolism of tissues
Greig, M. E., & Munro, M. P. (1939) · Biochemical Journal · doi:10.1042/bj0330143 · Cited by 13 · see citing works
Neuere Erkenntnisse über den Mechanismus der Atmung und Gärung (Desmolyse)
Franke, W. (1940) · Angewandte Chemie · doi:10.1002/ange.19400535103 · Cited by 12 · see citing works
The metabolism of lactic and pyruvic acids in normal and tumour tissues
Greig, M. E., Munro, M. P., & Elliott, K. A. C. (1939) · Biochemical Journal · doi:10.1042/bj0330443 · Cited by 12 · see citing works
Effect of Succinic Acid on the Respiration of Normal Human Muscle and Various Myopathies
Stare, F. J., GORDON, E. S., & Musser, M. J. (1938) · Nature · doi:10.1038/141831a0 · Cited by 5 · see citing works
Self-citationNutrition Research from Respiration and Vitamins to Cholesterol and Atherosclerosis
Stare, F. J. (1991) · Annual Review of Nutrition · doi:10.1146/annurev.nu.11.070191.000245 · Cited by 4 · see citing works
Self-citationBiological Oxidation-Reduction Catalysts
Elliott, K. A. C. (1941) · Springer eBooks · doi:10.1007/978-3-7091-7990-1_3 · Cited by 4 · see citing works
- Authors
- Stare, F. J.
- Affiliations
- University of Szeged (HU)
- Corresponding author
- Stare, Fredrick John
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 1936-12-01
- Volume
- 30
- Issue
- 12
- Pages
- 2257-2261
- ISSN
- 0306-3283 (ISSN-L)
- PMC
- PMC1263334
- OpenAlex
- W2341399491
- Cited by
- 10
- References
- 0
- Citations by year
- 2022: 1
- FWCI
- 2.63
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Biochemical Journal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Biochemical Acid Research Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
- Keywords
- fumarate, cellular respiration, liver, kidney, cytochromes, hydrogen transport, oxaloacetate, succinic acid, malate, respiratory quotient, oxygen consumption
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