The amino-acid sequence in the glycyl chain of insulin. 2. The investigation of peptides from enzymic hydrolysates
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Frederick Sanger determined the amino acid sequences of the A and B chains of insulin; by 1955 he demonstrated the position of the two disulfide bonds linking the A and B chains and the intrachain disulfide bond within the A chain.
“In the early 1950s, Frederick Sanger determined the amino acid sequences of the A and B chains of insulin87–90. By 1955, he would demonstrate the position of the two disulfide bonds linking the A and B chains and the intrachain disulfide bond within the A chain, and in 1958, he was awarded the Nobel Prize in Chemistry91–93.”
From 100 years of insulin: celebrating the past, present and future of diabetes therapy (2021) · cites this paper as [90]
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- Woolley, D. W. (1948). Fed. Proc. 7, 200.
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Ruiz-Mirazo, K., Briones, C., & de la Escosura, A. (2014) · Chemical Reviews · doi:10.1021/cr2004844 · Cited by 930 · see citing works
Trends in insulin resistance: insights into mechanisms and therapeutic strategy
Li, M., Chi, X., Wang, Y., Setrerrahmane, S., Xie, W., & Xu, H. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01073-0 · Cited by 939 · see citing works
100 years of insulin: celebrating the past, present and future of diabetes therapy
Sims, E. K., Carr, A. L. J., Oram, R. A., DiMeglio, L. A., & Evans-Molina, C. (2021) · Nature Medicine · doi:10.1038/s41591-021-01418-2 · Cited by 270 · see citing works
Sanger, F. (1959) · Science · doi:10.1126/science.129.3359.1340 · Cited by 255 · see citing works
Self-citation
- Authors
- Sanger, F., & Thompson, E. O. P.
- Affiliations
- University of Cambridge (GB)
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 1953-02-01
- Volume
- 53
- Issue
- 3
- Pages
- 366-374
- ISSN
- 0306-3283 (ISSN-L)
- PMC
- PMC1198158
- OpenAlex
- W4238785522
- Cited by
- 260
- References
- 0
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 7 · 2023: 7 · 2022: 34 · 2021: 13 · 2020: 6 · 2019: 3 · 2018: 3 · 2017: 6 · 2016: 3 · 2015: 2 · 2014: 4 · 2013: 3 · 2012: 3
- FWCI
- 56.53
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Biochemical Journal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
- Physical Sciences › Materials Science › Materials Chemistry › Enzyme Structure and Function
- Keywords
- insulin, amino acid sequence, peptide mapping, insulin B chain
- MeSH terms
- Amino Acid Sequence, Amino Acids, Insulin, Peptides
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