Cited by 255Pancreatic function and diabetesDiabetes Management and ResearchMass Spectrometry Techniques and Applications

Chemistry of Insulin: Determination of the structure of insulin opens the way to greater understanding of life processes

Sanger, F.·1959·Science

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Registry

Crossref · 10.1126/science.129.3359.1340

Cites

18 of 18 references verified0 citation errors · 0 not checkable

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  • Frederick Sanger determined the amino acid sequences of the A and B chains of insulin; by 1955 he demonstrated the position of the two disulfide bonds linking the A and B chains and the intrachain disulfide bond within the A chain.

    “In the early 1950s, Frederick Sanger determined the amino acid sequences of the A and B chains of insulin87–90. By 1955, he would demonstrate the position of the two disulfide bonds linking the A and B chains and the intrachain disulfide bond within the A chain, and in 1958, he was awarded the Nobel Prize in Chemistry91–93.”

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Authors
Sanger, F.
Affiliations
University of Cambridge (GB)
Corresponding author
Sanger, F.
Venue
Science
Published
1959-05-15
Volume
129
Issue
3359
Pages
1340-1344
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2010465462
Cited by
255
References
18
Citations by year
2026: 2 · 2025: 4 · 2024: 5 · 2023: 7 · 2022: 6 · 2021: 12 · 2020: 2 · 2019: 5 · 2018: 5 · 2017: 5 · 2016: 6 · 2015: 8 · 2014: 2 · 2013: 9 · 2012: 7
FWCI
14.41
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Physical Sciences › Chemistry › Spectroscopy › Mass Spectrometry Techniques and Applications
Keywords
insulin, insulin structure, peptide hormones, amino acid sequence
MeSH terms
Insulin, Life, Comprehension

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