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Cited by 193

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Antigenicity of insulin: diabetes induced by specific antibodies

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Moloney, P. J., Coval, M.·1955·Biochemical Journal

Abstract

Lewis (1937) sensitized guinea pigs with ox or pig insulin.Using the Dale technique, he observed contractions of uterine strips from these animals in response to both ox and pig insulin.There was a more persistent response to the preparation of insulin which had been used to sensitize the animal.Bernstein, Kirsner & Turner (1938) have reported anaphylaxis in guinea pigs sensitized and challenged with various insulin preparations.Wasserman & Mirsky (1942) showed that anaphylaxis could be induced in guinea pigs with insulin of a different species than that used for sensitization.Banting, Franks & Gairns (1938) reported the development of resistance to insulin in a non-diabetic schizophrenic patient following a course of insulin shock treat- ment.Blood serum from this patient, mixed with 12-2

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Metadata

Authors
Moloney, P. J., & Coval, M.
Venue
Biochemical Journal
Published
1955-02-01
Volume
59
Issue
2
Pages
179-185
ISSN
0306-3283 (ISSN-L)
OpenAlex
W1208560999
Cited by
193
References
0
FWCI
13.73
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Antigenicity of insulin: diabetes induced by specific antibodies. https://app.cochat.ai/papers/10.1042/bj0590179
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Moloney, P. J., & Coval, M. (1955). Antigenicity of insulin: diabetes induced by specific antibodies. Biochemical Journal. https://doi.org/10.1042/bj0590179

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