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Antigenicity of insulin: diabetes induced by specific antibodies
Open accessAbstract
Lewis (1937) sensitized guinea pigs with ox or pig insulin.Using the Dale technique, he observed contractions of uterine strips from these animals in response to both ox and pig insulin.There was a more persistent response to the preparation of insulin which had been used to sensitize the animal.Bernstein, Kirsner & Turner (1938) have reported anaphylaxis in guinea pigs sensitized and challenged with various insulin preparations.Wasserman & Mirsky (1942) showed that anaphylaxis could be induced in guinea pigs with insulin of a different species than that used for sensitization.Banting, Franks & Gairns (1938) reported the development of resistance to insulin in a non-diabetic schizophrenic patient following a course of insulin shock treat- ment.Blood serum from this patient, mixed with 12-2
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Citations
Cited by
Hormone-fuel interrelationships during fasting.
Cahill, G. F., Herrera, M. G., Morgan, A. P., Soeldner, J. S., Steinke, J., Levy, P. L., Reichard, G. A., & Kipnis, D. M. (1966) · Journal of Clinical Investigation · doi:10.1172/jci105481 · Cited by 1,036
Froesch, E. R., Bürgi, H., Ramseier, E. B., Bally, P., & Labhart, A. (1963) · Journal of Clinical Investigation · doi:10.1172/jci104866 · Cited by 419
Jefferson, L. S., Exton, J. H., Butcher, R. W., Sutherland, E. W., & Park, C. R. (1968) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)93618-5 · Cited by 326
Species variation in the amino acid sequence of insulin
Smith, L. F. (1966) · The American Journal of Medicine · doi:10.1016/0002-9343(66)90145-8 · Cited by 320
Renold, A. E., Martin, D. B., Dagenais, Y. M., Steinke, J., Nickerson, R. J., & Sheps, M. C. (1960) · Journal of Clinical Investigation · doi:10.1172/jci104168 · Cited by 287
Metadata
- Authors
- Moloney, P. J., & Coval, M.
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 1955-02-01
- Volume
- 59
- Issue
- 2
- Pages
- 179-185
- ISSN
- 0306-3283 (ISSN-L)
- OpenAlex
- W1208560999
- Cited by
- 193
- References
- 0
- FWCI
- 13.73
- Type
- journal article
- Language
- en
- Open access
- bronze
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