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Statistical estimations in enzyme kinetics
Open accessAbstract
Although elementary statistical methods such as the calculation of means and their standard errors are commonly employed, application of the statistical methods of regression analysis in enzyme kinetic studies has received little attention.In estimating the kinetic parameters of the Michaelis-Menten equation, for instance, graphical methods such as the double-reciprocal plot (Lineweaver & Burk, 1934) are generally used, without supple- mentary statistical calculations.These methods have been reviewed by Dixon & Webb (1958).Graphical methods, however, do not usually provide any measure of the precision of the deter- minations, a knowledge of which is necessary for a proper evaluation of the results in relation to theoretical considerations, or for a comparison of results obtained under differing experimental conditions.The main purpose of a statistical analysis is to supply, not only more accurate estimates, but also the necessary measures of
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Cited by
Berg, H. C., & Purcell, E. M. (1977) · Biophysical Journal · doi:10.1016/s0006-3495(77)85544-6 · Cited by 1,758
MENTLEIN, R., GALLWITZ, B., & SCHMIDT, W. E. (1993) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1993.tb17986.x · Cited by 1,161
Fidelity of HIV-1 reverse transcriptase
Preston, B. D., Poiesz, B. J., & Loeb, L. A. (1988) · Science · doi:10.1126/science.2460924 · Cited by 931
The kinetics of enzyme-catalyzed reactions with two or more substrates or products
Cleland, W. W. (1963) · Biochimica et Biophysica Acta (BBA) - Specialized Section on Enzymological Subjects · doi:10.1016/0926-6569(63)90226-8 · Cited by 789
The role of phospholipids and factor Va in the prothrombinase complex.
Rosing, J., Tans, G., Govers-Riemslag, J. W., Zwaal, R. F., & Hemker, H. C. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)86294-4 · Cited by 668
Metadata
- Authors
- WILKINSON, G.
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 1961-08-01
- Volume
- 80
- Issue
- 2
- Pages
- 324-332
- ISSN
- 0006-2936 (ISSN-L)
- OpenAlex
- W2397861637
- Cited by
- 3,552
- References
- 0
- FWCI
- 21.34
- Type
- journal article
- Language
- en
- Open access
- bronze
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