The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
GLUTATHIONE PEROXIDASE IN LENS AND A SOURCE OF HYDROGEN PEROXIDE IN AQUEOUS HUMOUR
Open accessAbstract
1. Glutathione peroxidase has been demonstrated in cattle, rabbit and guineapig lenses. 2. The enzyme will oxidize GSH either with hydrogen peroxide added at the start of the reaction or with hydrogen peroxide generated enzymically with glucose oxidase. 3. No product other than GSSG was detected. 4. Oxidation of GSH can be coupled with oxidation of malate through the intermediate reaction of glutathione reductase and NADPH(2). 5. Traces of hydrogen peroxide are present in aqueous humour: it is formed when the ascorbic acid of aqueous humour is oxidized. 6. Hydrogen peroxide will diffuse into the explanted intact lens and oxidize the contained GSH. The addition of glucose to the medium together with hydrogen peroxide maintains the concentration of lens GSH. 7. Glutathione peroxidase in lens extracts will couple with the oxidation of ascorbic acid. 8. It is suggested that, as there is only weak catalase activity in lens, glutathione peroxidase may act as one link between the oxygen of the aqueous humour and NADPH(2).
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Citations
Cites
Glutathione Peroxidase: The Primary Agent for the Elimination of Hydrogen Peroxide in Erythrocytes*
Cohen, G., & Hochstein, P. (1963) · Biochemistry · doi:10.1021/bi00906a038 · Cited by 666
Cited by
Hydrogen peroxide and human cataract
Spector, A., & Garner, W. H. (1981) · Experimental Eye Research · doi:10.1016/s0014-4835(81)80107-8 · Cited by 502
Metadata
- Authors
- PIRIE, A.
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 1965-07-01
- Volume
- 96
- Issue
- 1
- Pages
- 244-253
- ISSN
- 0006-2936 (ISSN-L)
- OpenAlex
- W2112277988
- Cited by
- 185
- References
- 1
- FWCI
- 1.42
- Type
- journal article
- Language
- en
- Open access
- bronze
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- PIRIE, A. (1965). GLUTATHIONE PEROXIDASE IN LENS AND A SOURCE OF HYDROGEN PEROXIDE IN AQUEOUS HUMOUR. Biochemical Journal. https://doi.org/10.1042/bj0960244
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