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Release of enzymes from lysosomes by irradiation and the relation of lipid peroxide formation to enzyme release
Open accessAbstract
1. Acid phosphatase, cathepsin and beta-glucuronidase are released from rat-liver lysosomes by irradiation in vitro. Enzyme release is detectable after a dose of 1krad and increases with dose up to 100krads. 2. Maximum radiation effects were observed when the lysosomes were kept for 20hr. at 4 degrees or 20 degrees after irradiation. 3. An atmosphere of nitrogen considerably decreases enzyme release from lysosomes. 4. Enzyme release is enhanced by ascorbic acid and decreased by vitamin E. 5. Irradiation causes formation of lipid peroxides in lysosomes, and enzyme release increases with lipid peroxide formation. 6. It is suggested that lipid peroxide formation leads to rupture of the lysosome membrane and allows release of the contained hydrolytic enzymes.
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Cited by
Teratogens and craniofacial malformations: relationships to cell death
Sulik, K. K., Cook, C. S., & Webster, W. S. (1988) · Development · doi:10.1242/dev.103.supplement.213 · Cited by 403
Oxidation of Polyunsaturated Fatty Acids: Mechanisms, Products, and Inhibition with Emphasis on Fish
Hsieh, R. J., & Kinsella, J. E. (1989) · Advances in Food and Nutrition Research · doi:10.1016/s1043-4526(08)60129-1 · Cited by 366
Lipid Peroxidation and Mechanisms of Toxicity
Horton, A. A., Fairhurst, S., & Bus, J. S. (1987) · CRC Critical Reviews in Toxicology · doi:10.3109/10408448709089856 · Cited by 339
Free radical scavenging action of the natural polyamine spermine in rat liver mitochondria
Sava, I. G., Battaglia, V., Rossi, C. A., Salvi, M., & Toninello, A. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.07.008 · Cited by 94
Jajte, J., Lao, I., & Wisniewska-Knypl, J. M. (1987) · Occupational and Environmental Medicine · doi:10.1136/oem.44.3.180 · Cited by 1
Metadata
- Authors
- Wills, E., & Wilkinson, A.
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 1966-06-01
- Volume
- 99
- Issue
- 3
- Pages
- 657-666
- ISSN
- 0006-2936 (ISSN-L)
- OpenAlex
- W1548153124
- Cited by
- 208
- References
- 0
- FWCI
- 29.40
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Wills, E., & Wilkinson, A. (1966). Release of enzymes from lysosomes by irradiation and the relation of lipid peroxide formation to enzyme release. Biochemical Journal. https://doi.org/10.1042/bj0990657
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
