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The distribution of glutamate decarboxylase and aspartate transaminase in subcellular fractions of rat and guinea-pig brain
Open accessAbstract
1. The subcellular distributions of glutamate decarboxylase and aspartate transaminase were studied in rat and guinea-pig brain. 2. Glutamate decarboxylase is localized in the synaptosome fraction. The mean density of the particles containing the enzyme is slightly greater than those derived from cholinergic neurones, though overlap is substantial. 3. The enzyme is readily released from synaptosomes by hypo-osmotic treatment, but in the presence of Ca2+, Na+ and K+ it sediments with particulate material. 4. The release and binding of the enzyme to membrane fractions by Ca2+ were investigated. 5. Aspartate transaminase is present in brain as two isoenzymes with different kinetic properties. One isoenzyme is associated with the cytoplasm and the other with mitochondria.
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Cited by
Two genes encode distinct glutamate decarboxylases
Erlander, M. G., Tillakaratne, N. J. K., Feldblum, S., Patel, N., & Tobin, A. J. (1991) · Neuron · doi:10.1016/0896-6273(91)90077-d · Cited by 1,213
GABA neurons are the major cell type of the nucleus reticularis thalami
Houser, C. R., Vaughn, J. E., Barber, R. P., & Roberts, E. (1980) · Brain Research · doi:10.1016/0006-8993(80)90925-7 · Cited by 668
Esclapez, M., Tillakaratne, N., Kaufman, D., Tobin, A., & Houser, C. (1994) · The Journal of Neuroscience · doi:10.1523/jneurosci.14-03-01834.1994 · Cited by 614
Regulation of γ‐Aminobutyric Acid Synthesis in the Brain
Martin, D. L., & Rimvall, K. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb03165.x · Cited by 614
Transport and Metabolism of Glutamate and Gaba in Neurons and Glial Cells
Schousboe, A. (1981) · International Review of Neurobiology · doi:10.1016/s0074-7742(08)60289-5 · Cited by 440
Metadata
- Authors
- Fonnum, F.
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 1968-01-01
- Volume
- 106
- Issue
- 2
- Pages
- 401-412
- ISSN
- 0306-3283 (ISSN-L)
- OpenAlex
- W2237832779
- Cited by
- 251
- References
- 0
- FWCI
- 9.39
- Type
- journal article
- Language
- en
- Open access
- bronze
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