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Specificity of combination between mucopeptide precursors and vancomycin or ristocetin
Open accessAbstract
Vancomycin and ristocetin formed complexes on being mixed with mucopeptide precursors from various bacteria, as shown by chromatography, electrophoresis and differential ultraviolet spectra. Equimolar proportions of antibiotic and peptide were present. The specificity of the reaction was studied and the smallest molecule found to react was acetyl-d-alanyl-d-alanine. This C-terminal dipeptide sequence must be present for complex-formation; change of configuration or esterification prevented it. Modified vancomycins that retained antibiotic activity also combined with appropriate peptides. The dissociation constants of the more stable complexes were estimated from the differential-absorption results. The relationship of complex-formation to antibiotic action is discussed. Penicillin, supposed to be an analogue of acyl-d-alanyl-d-alanine, also modified the spectrum of vancomycin; so, too, did sodium benzylpenicilloate.
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Cites
Tipper, D. J., & Strominger, J. L. (1965) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.54.4.1133 · Cited by 1,008
Cited by
Plasmid-Mediated Resistance to Vancomycin and Teicoplanin in Enterococcus Faecium
Leclercq, R., Derlot, E., Duval, J., & Courvalin, P. (1988) · New England Journal of Medicine · doi:10.1056/nejm198807213190307 · Cited by 1,425
Structure, biochemistry and mechanism of action of glycopeptide antibiotics
Reynolds, P. E. (1989) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/bf01967563 · Cited by 699
The Lantibiotic Mersacidin Inhibits Peptidoglycan Synthesis by Targeting Lipid II
Brötz, H., Bierbaum, G., Leopold, K., Reynolds, P. E., & Sahl, H.-G. (1998) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.42.1.154 · Cited by 381
Transferable vancomycin and teicoplanin resistance in Enterococcus faecium
Leclercq, R., Derlot, E., Weber, M., Duval, J., & Courvalin, P. (1989) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.33.1.10 · Cited by 306
Structure of vancomycin and its complex with acetyl-D-alanyl-D-alanine
Sheldrick, G. M., Jones, P. G., Kennard, O., Williams, D. H., & Smith, G. A. (1978) · Nature · doi:10.1038/271223a0 · Cited by 297
Metadata
- Authors
- Perkins, H. R.
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 1969-01-01
- Volume
- 111
- Issue
- 2
- Pages
- 195-205
- ISSN
- 0306-3283 (ISSN-L)
- OpenAlex
- W2402066319
- Cited by
- 279
- References
- 1
- FWCI
- 15.94
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
