The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Transferable vancomycin and teicoplanin resistance in Enterococcus faecium
Open accessAbstract
Enterococcus faecium BM4165 and BM4178, isolated from immunocompromised patients, one treated with vancomycin, were inducibly resistant to high levels of the glycopeptide antibiotics vancomycin and teicoplanin but susceptible to the new lipopeptide daptomycin (LY146032). Strain BM4165 was also resistant to macrolidelincosamide-streptogramin B-type (MLS) antibiotics. The genes conferring resistance to glycopeptides and to MLS antibiotics in strain BM4165 were carried on plasmids pIP819 and pIP821, respectively; pIP819 also carried genes that encoded resistance to MLS antibiotics. The two plasmids, which were distinct although related, were self-transferable to other E. faecium strains. Plasmid pIP819 could also conjugate to E. faecalis, Streptococcus sanguis, S. pyogenes, S. lactis, and Listeria monocytogenes, in which it conferred inducible glycopeptide resistance, but not to S. aureus. Glycopeptide-inactivating activity was not detected, and the biochemical mechanism of resistance remains unknown. Based on this first report of transferable resistance to glycopeptides, we anticipate dissemination of resistance to these antibiotics in gram-positive cocci and bacilli in which it can be phenotypically expressed.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Schleifer, K. H., & Kilpper-Balz, R. (1984) · International Journal of Systematic Bacteriology · doi:10.1099/00207713-34-1-31 · Cited by 603
Cited by
The crisis in antibiotic resistance
Neu, H. C. (1992) · Science · doi:10.1126/science.257.5073.1064 · Cited by 2,834
Demonstration of safety of probiotics—A review
Salminen, S. (1998) · International Journal of Food Microbiology · doi:10.1016/s0168-1605(98)00128-7 · Cited by 884
PATHOGENS RESISTANT TO ANTIMICROBIAL AGENTS
Fraimow, H. S., & Abrutyn, E. (1995) · Infectious Disease Clinics of North America · doi:10.1016/s0891-5520(20)30683-8 · Cited by 37
Garcia-Migura, L., Hasman, H., Svendsen, C., & Jensen, L. B. (2008) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkn265 · Cited by 18
Metadata
- Authors
- Leclercq, R., Derlot, E., Weber, M., Duval, J., & Courvalin, P.
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 1989-01
- Volume
- 33
- Issue
- 1
- Pages
- 10-15
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- OpenAlex
- W2160112462
- Cited by
- 306
- References
- 1
- FWCI
- 19.53
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Transferable vancomycin and teicoplanin resistance in Enterococcus faecium. https://app.cochat.ai/papers/10.1128/aac.33.1.10
- The paper
- Leclercq, R., Derlot, E., Weber, M., Duval, J., & Courvalin, P. (1989). Transferable vancomycin and teicoplanin resistance in Enterococcus faecium. Antimicrobial Agents and Chemotherapy. https://doi.org/10.1128/aac.33.1.10
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
