Interaction of nitrite with mammalian mitochondrial cytochromes
Open accessAbstract
9Poverall toxicity of repeated doses of 40, 30 and 20 mg of diethylnitrosamine/kg, as manifested by faster growth rate and increased surviving time.In conclusion, the experimental findings suggest that the metabolism of diethylnitrosamine can be stimulated by various inducers of drug-metabolizing enzymes and that diethylnitrosamine inhibits de novo synthesis of de-ethylating enzymes and also impairs the function of the preformed enzymes.The induced metabolism of diethylnitrosamine and protein synthesis by phenobarbitone decreased the subacute toxicity.This protection against diethylnitrosamine toxicity in vivo by phenobarbitone is probably due to the formation of non-toxic metab- olites; however, some additional mechanisms may also participate in this effect.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The text we found for this paper looks like another document, so the self-check wasn’t run.
Cites
Hematin compounds and bile pigments
Lemberg, R., & Legge, J. W. (1949) · Cited by 914 · see citing works
THE KINETICS AND INHIBITION OF CYTOCHROME COMPONENTS OF THE SUCCINIC OXIDASE SYSTEM
Chance, B. (1952) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)55610-6 · Cited by 79 · see citing works
Induction of a new hepatic microsomal haemoprotein by safrole and isosafrole
Parke, D. V. W., & Rahman, H. (1971) · Biochemical Journal · doi:10.1042/bj1230009pb · Cited by 42 · see citing works
Nitrite metabolism by muscle in vitro
Walters, C. L., & Taylor, A. M. (1964) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(64)90084-4 · Cited by 31 · see citing works
Self-citationMyoglobin in heart-muscle preparations and the effect of nitrite treatment
Colpa-Boonstra, J. P., & Minnaert, K. (1959) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(59)90144-1 · Cited by 22 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Inorganic nitrite therapy: historical perspective and future directions
Kevil, C. G., Kolluru, G. K., Pattillo, C. B., & Giordano, T. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.04.042 · Cited by 113 · see citing works
- Authors
- Burger, I. H., & Walters, C. L.
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 1971-06-01
- Volume
- 123
- Issue
- 2
- Pages
- 9P-9P
- ISSN
- 0306-3283 (ISSN-L)
- PMC
- PMC1176952
- OpenAlex
- W2400763228
- Cited by
- 5
- References
- 5
- FWCI
- 0.44
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Biochemical Journal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Nuffield Foundation
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Bioactive Compounds and Antitumor Agents
- Keywords
- nitrite, mitochondrial cytochromes, diethylnitrosamine, phenobarbital, drug-metabolizing enzyme induction, subacute toxicity, enzyme inhibition
- MeSH terms
- Animals, Cyanides, Electron Transport Complex IV, Cytochromes, Mitochondria, Muscle, Nitrites, Oxidation-Reduction, Swine
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
