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The relative importance of muscle protein synthesis and breakdown in the regulation of muscle mass
Open accessAbstract
The effects of growth-suppressing and muscle-wasting treatments on muscle protein turnover and amino acid concentrations were determined in vivo. All treatments depressed protein synthesis and some treatments depressed protein breakdown. Only prolonged starvation increased protein breakdown. Muscle protein mass is regulated primarily through alterations in protein synthesis in all except emergency conditions. The increased concentrations of the branched-chain amino acids indicate that they are unlikely to be involved in this regulation.
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Citations
Cited by
Intracellular Protein Catabolism and its Control During Nutrient Deprivation and Supply
Mortimore, G. E., & Pösö, A. R. (1987) · Annual Review of Nutrition · doi:10.1146/annurev.nu.07.070187.002543 · Cited by 458
Tomas, F. M., Munro, H. N., & Young, V. R. (1979) · Biochemical Journal · doi:10.1042/bj1780139 · Cited by 293
Sleep and muscle recovery: Endocrinological and molecular basis for a new and promising hypothesis
Dattilo, M., Antunes, H. K. M., Medeiros, A., Mônico Neto, M., Souza, H. S., Tufik, S., & de Mello, M. T. (2011) · Medical Hypotheses · doi:10.1016/j.mehy.2011.04.017 · Cited by 290
Increased proteolysis. An effect of increases in plasma cortisol within the physiologic range.
Simmons, P. S., Miles, J. M., Gerich, J. E., & Haymond, M. W. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111227 · Cited by 286
4E-BP1 and S6K1: translational integration sites for nutritional and hormonal information in muscle
Shah, O. J., Anthony, J. C., Kimball, S. R., & Jefferson, L. S. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.279.4.e715 · Cited by 286
Metadata
- Authors
- Millward, D. J., Garlick, P. J., Nnanyelugo, D. O., & Waterlow, J. C.
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 1976-04-15
- Volume
- 156
- Issue
- 1
- Pages
- 185-188
- ISSN
- 0264-6021 (ISSN-L)
- OpenAlex
- W2194940061
- Cited by
- 348
- References
- 0
- FWCI
- 8.65
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Millward, D. J., Garlick, P. J., Nnanyelugo, D. O., & Waterlow, J. C. (1976). The relative importance of muscle protein synthesis and breakdown in the regulation of muscle mass. Biochemical Journal. https://doi.org/10.1042/bj1560185
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
