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The role of link-protein in the structure of cartilage proteoglycan aggregates
Open accessAbstract
Proteoglycan fractions were prepared from pig laryngeal cartilage. The effect of link-protein on the properties of proteoglycan-hyaluronate aggregates was examined by viscometry and analytical ultracentrifugation. Aggregates containing link-protein were more stable than link-free aggregates at neutral pH, at temperatures up to 50 degrees C and in urea (up to 4.0M). Oligosaccharides of hyaluronate were able to displace proteoglycans from link-free aggregates, but not from the link-stabilized aggregates. Both types of aggregate were observed in the ultracentrifuge, but at the concentration investigated (less than 2 mg/ml) the link-free form was partially dissociated and the proportion aggregated varied with the pH and temperature and required more hyaluronate for saturation than did link-stabilized aggregate. The results showed that link-protein greatly strengthened the binding of proteoglycans to hyaluronate and suggest that under physiological conditions it ‘locks’ proteoglycans on to the hyaluronate chain.
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The specific interaction of hyaluronic acid with cartilage proteoglycans.
HARDINGHAM, T., & MUIR, H. (1972) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(72)90160-2 · Cited by 645
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Cited by
Chung, C., & Burdick, J. A. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.08.027 · Cited by 760
Hyaluronan, a Crucial Regulator of Inflammation
Petrey, A. C., & de la Motte, C. A. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00101 · Cited by 514
Seror, J., Merkher, Y., Kampf, N., Collinson, L., Day, A. J., Maroudas, A., & Klein, J. (2011) · Biomacromolecules · doi:10.1021/bm2004912 · Cited by 159
Carulli, D., Rhodes, K. E., & Fawcett, J. W. (2007) · Journal of Comparative Neurology · doi:10.1002/cne.21231 · Cited by 158
Day, J. M., Olin, A. I., Murdoch, A. D., Canfield, A., Sasaki, T., Timpl, R., Hardingham, T. E., & Aspberg, A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400242200 · Cited by 127
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Metadata
- Authors
- Hardingham, T. E.
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 1979-01-01
- Volume
- 177
- Issue
- 1
- Pages
- 237-247
- ISSN
- 0264-6021 (ISSN-L)
- OpenAlex
- W2103749562
- Cited by
- 369
- References
- 1
- FWCI
- 8.55
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Hardingham, T. E. (1979). The role of link-protein in the structure of cartilage proteoglycan aggregates. Biochemical Journal. https://doi.org/10.1042/bj1770237
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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