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A rapid and convenient technique for measuring the rate of protein synthesis in tissues by injection of [3H]phenylalanine
Open accessAbstract
A rapid procedure for measuring the specific radioactivity of phenylalanine in tissues was developed. This facilitates the accurate determination of rates of protein synthesis in a wide range of tissues by injection of 150 mumol of L-[4-(3)H]phenylalanine/100 g body wt. The large dose of amino acid results in a rapid rise in specific radioactivity of free phenylalanine in tissues to values close to that in plasma, followed by a slow but linear fall. This enables the rate of protein synthesis to be calculated from measurements of the specific radioactivity of free and protein-bound phenylalanine in tissues during a 10 min period after injection of radioisotope.
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Cited by
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Oral leucine administration stimulates protein synthesis in rat skeletal muscle
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Metadata
- Authors
- Garlick, P. J., McNurlan, M. A., & Preedy, V. R.
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 1980-11-15
- Volume
- 192
- Issue
- 2
- Pages
- 719-723
- ISSN
- 0306-3283 (ISSN-L)
- OpenAlex
- W1868948982
- Cited by
- 973
- References
- 0
- FWCI
- 5.58
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: A rapid and convenient technique for measuring the rate of protein synthesis in tissues by injection of [3H]phenylalanine. https://app.cochat.ai/papers/10.1042/bj1920719
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- Garlick, P. J., McNurlan, M. A., & Preedy, V. R. (1980). A rapid and convenient technique for measuring the rate of protein synthesis in tissues by injection of [3H]phenylalanine. Biochemical Journal. https://doi.org/10.1042/bj1920719
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
