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Hepatically derived selenoprotein P is a key factor for kidney but not for brain selenium supply
Open accessAbstract
Liver-specific inactivation of Trsp, the gene for selenocysteine tRNA, removes SePP (selenoprotein P) from plasma, causing serum selenium levels to fall from 298 μg/l to 50 μg/l and kidney selenium to decrease to 36% of wild-type levels. Likewise, glutathione peroxidase activities decreased in plasma and kidney to 43% and 18% respectively of wild-type levels. This agrees nicely with data from SePP knockout mice, supporting a selenium transport role for hepatically expressed SePP. However, brain selenium levels remain unaffected and neurological defects do not occur in the liver-specific Trsp knockout mice, while SePP knockout mice suffer from neurological defects. This indicates that a transport function in plasma is exerted by hepatically derived SePP, while in brain SePP fulfils a second, hitherto unexpected, essential role.
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Cites
Tissue-specific functions of individual glutathione peroxidases
Brigelius-Flohé, R. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00173-2 · Cited by 1,114
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Paradoxical Roles of Antioxidant Enzymes: Basic Mechanisms and Health Implications
Lei, X. G., Zhu, J.-H., Cheng, W.-H., Bao, Y., Ho, Y.-S., Reddi, A. R., Holmgren, A., & Arnér, E. S. J. (2016) · Physiological Reviews · doi:10.1152/physrev.00010.2014 · Cited by 429
Metadata
- Authors
- SCHWEIZER, U., STRECKFUß, F., PELT, P., CARLSON, B. A., HATFIELD, D. L., KÖHRLE, J., & SCHOMBURG, L.
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 2005-02-22
- Volume
- 386
- Issue
- 2
- Pages
- 221-226
- ISSN
- 0264-6021 (ISSN-L)
- 1470-8728
- OpenAlex
- W1990660710
- Cited by
- 207
- References
- 1
- FWCI
- 13.35
- Type
- journal article
- Language
- en
- Open access
- green
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- SCHWEIZER, U., STRECKFUß, F., PELT, P., CARLSON, B. A., HATFIELD, D. L., KÖHRLE, J., & SCHOMBURG, L. (2005). Hepatically derived selenoprotein P is a key factor for kidney but not for brain selenium supply. Biochemical Journal. https://doi.org/10.1042/bj20041973
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