Selenium in human health and disease

Fairweather-Tait, Susan J.; Bao, Yongping; Broadley, Martin R.; Collings, Rachel; Ford, Dianne; Hesketh, John E.; Hurst, Rachel

doi:10.1089/ars.2010.3275

Cited by 1,330Selenium in Biological SystemsOrganoselenium and organotellurium chemistryTrace Elements in Health

Selenium in human health and disease

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Fairweather-Tait, Susan J., Bao, Yongping, Broadley, Martin R., Collings, Rachel, Ford, Dianne, Hesketh, John E., Hurst, Rachel·2011·Antioxidants & Redox Signaling

DOI 10.1089/ars.2010.3275

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Abstract

This review covers current knowledge of selenium in the environment, dietary intakes, metabolism and status, functions in the body, thyroid hormone metabolism, antioxidant defense systems and oxidative metabolism, and the immune system. Selenium toxicity and links between deficiency and Keshan disease and Kashin-Beck disease are described. The relationships between selenium intake/status and various health outcomes, in particular gastrointestinal and prostate cancer, cardiovascular disease, diabetes, and male fertility, are reviewed, and recent developments in genetics of selenoproteins are outlined. The rationale behind current dietary reference intakes of selenium is explained, and examples of differences between countries and/or expert bodies are given. Throughout the review, gaps in knowledge and research requirements are identified. More research is needed to improve our understanding of selenium metabolism and requirements for optimal health. Functions of the majority of the selenoproteins await characterization, the mechanism of absorption has yet to be identified, measures of status need to be developed, and effects of genotype on metabolism require further investigation. The relationships between selenium intake/status and health, or risk of disease, are complex but require elucidation to inform clinical practice, to refine dietary recommendations, and to develop effective public health policies.

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Adequate selenium intake has a narrow range: 30 μg/day is inadequate for humans, while intakes exceeding 900 μg/day are potentially harmful.
“an intake of Se of 30 μg·day−1 is inadequate for humans, while intakes exceeding 900 μg·day−1 are potentially harmful [9]”
From Selenium Cycling Across Soil-Plant-Atmosphere Interfaces: A Critical Review (2015) · cites this paper as [9]
Higher animals and humans directly acquire organic Se compounds (SeMet and SeCys are the major Se species in the diet) but can also internalize inorganic Se.
“In general, higher animals and humans directly acquire organic Se compounds (SeMet and SeCys are the major Se species in the diet) but they can also internalize inorganic Se [9].”
From Selenium Cycling Across Soil-Plant-Atmosphere Interfaces: A Critical Review (2015) · cites this paper as [9]
Selenium exhibits strong antioxidant properties and protects against DNA damage.
“Selenium exhibits strong antioxidant properties and protects against DNA damage [88,89].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [88]
Selenium occurs in two forms: inorganic (selenates and selenites) and organic (selenomethionine and selenocysteine).
“It occurs in two forms: inorganic (selenates and selenites) and organic (selenomethionine and selenocysteine) [88].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [88]
Selenium should be supplied to the human body with foods of plant and animal origin.
“Selenium should be supplied to the human body with foods of plant and animal origin [26,88] (Table 1).”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [88]

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Self-citation
Intake of Selenium in the Prevention of Prostate Cancer: a Systematic Review and Meta-analysis*
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Selenium and human health
Rayman, M. P. (2012) · The Lancet · doi:10.1016/s0140-6736(11)61452-9 · Cited by 3,563 · see citing works
Selenium for preventing cancer
Vinceti, M., Filippini, T., Del Giovane, C., Dennert, G., Zwahlen, M., Brinkman, M., Zeegers, M. P., Horneber, M., D'Amico, R., & Crespi, C. M. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005195.pub4 · Cited by 649 · see citing works
Selenium Cycling Across Soil-Plant-Atmosphere Interfaces: A Critical Review
Winkel, L., Vriens, B., Jones, G., Schneider, L., Pilon-Smits, E., & Bañuelos, G. (2015) · Nutrients · doi:10.3390/nu7064199 · Cited by 476 · see citing works
“Adequate Se intake levels have a relatively narrow range between deficiency and toxicity: current estimates indicate that an intake of Se of 30 μg·day−1 is inadequate for humans, while intakes exceeding 900 μg·day−1 are potentially harmful [9].”
Background
Dietary calcium and zinc deficiency risks are decreasing but remain prevalent
Kumssa, D. B., Joy, E. J. M., Ander, E. L., Watts, M. J., Young, S. D., Walker, S., & Broadley, M. R. (2015) · Scientific Reports · doi:10.1038/srep10974 · Cited by 455 · see citing works
Bioactive Compounds for Skin Health: A Review
Michalak, M., Pierzak, M., Kręcisz, B., & Suliga, E. (2021) · Nutrients · doi:10.3390/nu13010203 · Cited by 345 · see citing works
“Selenium should be supplied to the human body with foods of plant and animal origin [26,88] (Table 1).”
Background
Selenium exposure and the risk of type 2 diabetes: A systematic review and meta-analysis
Vinceti, M., Filippini, T., & Rothman, K. J. (2018) · European Journal of Epidemiology · doi:10.1007/s10654-018-0422-8 · Cited by 233 · see citing works
Thiosulfoxide (sulfane) sulfur: new chemistry and new regulatory roles in biology
Toohey, J., & Cooper, A. (2014) · Molecules · doi:10.3390/molecules190812789 · Cited by 173 · see citing works
Maize grain and soil surveys reveal suboptimal dietary selenium intake is widespread in Malawi
Chilimba, A. D. C., Young, S. D., Black, C. R., Rogerson, K. B., Ander, E. L., Watts, M. J., Lammel, J., & Broadley, M. R. (2011) · Scientific Reports · doi:10.1038/srep00072 · Cited by 147 · see citing works
Self-citation
High-dose intravenous selenium does not improve clinical outcomes in the critically ill: a systematic review and meta-analysis
Manzanares, W., Lemieux, M., Elke, G., Langlois, P. L., Bloos, F., & Heyland, D. K. (2016) · Critical Care · doi:10.1186/s13054-016-1529-5 · Cited by 100 · see citing works
Prediagnostic selenium status and hepatobiliary cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort
Hughes, D. J., Duarte-Salles, T., Hybsier, S., Trichopoulou, A., Stepien, M., Aleksandrova, K., Overvad, K., Tjønneland, A., Olsen, A., Affret, A., et al. (2016) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.116.131672 · Cited by 91 · see citing works
Impact of Selenium on Biomarkers and Clinical Aspects Related to Ageing. A Review
Alehagen, U., Opstad, T. B., Alexander, J., Larsson, A., & Aaseth, J. (2021) · Biomolecules · doi:10.3390/biom11101478 · Cited by 69 · see citing works
Connection between the Altered HDL Antioxidant and Anti-Inflammatory Properties and the Risk to Develop Alzheimer’s Disease: A Narrative Review
Zimetti, F., Adorni, M. P., Marsillach, J., Marchi, C., Trentini, A., Valacchi, G., & Cervellati, C. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/6695796 · Cited by 49 · see citing works
Selenium deficiency sensitizes the skin for UVB-induced oxidative damage and inflammation which involved the activation of p38 MAPK signaling
Zhu, X., Jiang, M., Song, E., Jiang, X., & Song, Y. (2015) · Food and Chemical Toxicology · doi:10.1016/j.fct.2014.11.017 · Cited by 38 · see citing works
Potential Benefits of Selenium Supplementation in Reducing Insulin Resistance in Patients with Cardiometabolic Diseases: A Systematic Review and Meta-Analysis
Ouyang, J., Cai, Y., Song, Y., Gao, Z., Bai, R., & Wang, A. (2022) · Nutrients · doi:10.3390/nu14224933 · Cited by 36 · see citing works
Selenium-containing protein from selenium-enriched <i>Spirulina platensis</i> antagonizes oxygen glucose deprivation-induced neurotoxicity by inhibiting ROS-mediated oxidative damage through regulating MPTP opening
Song, X., Zhang, L., Hui, X., Sun, X., Yang, J., Wang, J., Wu, H., Wang, X., Zheng, Z., Che, F., et al. (2021) · Pharmaceutical Biology · doi:10.1080/13880209.2021.1928715 · Cited by 26 · see citing works

Effect of Dietary Selenium on Plasma Selenoprotein P, Selenoprotein P1 and Glutathione Peroxidase in the Rat
Motsenbocker, M. A., & Tappel, A. L. (1984) · Journal of Nutrition · doi:10.1093/jn/114.2.279 · Cited by 34 · see citing works
Utilization of selenium from different chemical entities for selenoprotein biosynthesis by mammalian cell lines.
Brigelius‐Flohé, R., Lötzer, K., Maurer, S., et al. (1997) · PubMed · Cited by 41 · see citing works
Selenoprotein P Concentration in Plasma is an Index of Selenium Status in Selenium-Deficient and Selenium-Supplemented Chinese Subjects
Hill, K. E., Xia, Y., Åkesson, B., Boeglin, M. E., & Burk, R. F. (1996) · Journal of Nutrition · doi:10.1093/jn/126.1.138 · Cited by 212 · see citing works
Effects of long-term selenium yeast supplementation on selenium status studied in the rat
BEHNE, D., Alber, D., & Kyriakopoulos, A. (2009) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2009.05.001 · Cited by 38 · see citing works
Establishment of Selenium-deficiency Mouse Model and Effects of Selenium-deficiency on Mouse Myocardium
Zhang, Q. (2010) · Zhongguo bijiao yixue zazhi

Authors: Fairweather-Tait, S. J., Bao, Y., Broadley, M. R., Collings, R., Ford, D., Hesketh, J. E., & Hurst, R.
Affiliations: University of East Anglia
University of East Anglia (GB)
University of Nottingham (GB)
Newcastle University (GB)
ORCID: Bao, Yongping
Broadley, Martin R.
Collings, Rachel
Ford, Dianne
Hurst, Rachel
Venue: Antioxidants & Redox Signaling
Publisher: SAGE Publications
Published: 2011-04
Volume: 14
Issue: 7
Pages: 1337-1383
ISSN: 1523-0864 (ISSN-L)
1557-7716
DOI: 10.1089/ars.2010.3275
OpenAlex: W2074769261
Cited by: 1,330
References: 426
Citations by year: 2026: 78 · 2025: 92 · 2024: 80 · 2023: 97 · 2022: 138 · 2021: 143 · 2020: 122 · 2019: 94 · 2018: 79 · 2017: 69 · 2016: 56 · 2015: 70 · 2014: 75 · 2013: 59 · 2012: 43
FWCI: 4.76
Type: journal article
Language: en
Open access: green
doi.org
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Antioxidants and Redox Signaling (publishedVersion)
PubMed (publishedVersion)
UEA Digital Repository (University of East Anglia) (submittedVersion)
Newcastle University ePrints (Newcastle Univesity)
Funders: Biotechnology and Biological Sciences Research Council (BB/G013969/1)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Selenium in Biological Systems
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Organoselenium and organotellurium chemistry
Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Keywords: selenium, selenoproteins, selenium metabolism, selenium status, dietary selenium intake, selenium toxicity, Keshan disease, Kashin-Beck disease, thyroid hormone metabolism, antioxidant defense, oxidative stress, immune function, gastrointestinal cancer, prostate cancer, cardiovascular disease, diabetes mellitus, male fertility, Dietary Reference Intakes
MeSH terms: Animals, Anti-Inflammatory Agents, Antioxidants, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Enterovirus Infections, Fertility Agents, Health, Humans, Intestinal Absorption, Mutation, Cardiomyopathies, Neoplasms, Nutritional Requirements, Selenium, Thyroid Hormones, Nutrition Policy, Selenoproteins, Kashin-Beck Disease

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Selenium in human health and disease

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