The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Molecular and functional characterization of a novel gonadotropin-releasing-hormone receptor isolated from the common octopus (Octopus vulgaris)
Open accessAbstract
GnRH (gonadotropin-releasing hormone) plays a pivotal role in the regulation of reproduction in vertebrates through interaction with a specific receptor. Previously, we isolated a GnRH homologue, oct-GnRH, from the common octopus (Octopus vulgaris). In the present study, we have identified a GnRH receptor (oct-GnRHR) specific for oct-GnRH from Octopus brain. Oct-GnRHR includes domains and motifs typical of vertebrate GnRH receptors. The intron-inserted positions are conserved between oct-GnRHR and the chordate GnRHR genes. The oct-GnRHR expressed in Xenopus (South African clawed frog) oocytes was responsive to oct-GnRH, but not to any other HPLC fractions of the Octopus brain extract. These results show that oct-GnRHR is an authentic receptor for oct-GnRH. Southern blotting of reverse-transcription PCR products revealed that the oct-GnRHR mRNA was widely distributed in the central and peripheral nervous systems and in several peripheral tissues. In situ hybridization showed that oct-GnRHR mRNA was expressed in some regions involved in autonomic functions, feeding, memory and movement. Oct-GnRH was shown to induce steroidogenesis of testosterone, progesterone and 17beta-oestradiol in Octopus ovary and testis, where oct-GnRHR was abundantly expressed. These results suggest that oct-GnRH, like its vertebrate counterparts, acts as a multifunctional neurotransmitter, neuromodulator and hormone-like factor, both in Octopus central nervous system and peripheral tissues, and that both structure and functions of the GnRH family are, at least partially, evolutionarily conserved between octopuses and chordates.
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“For instance, CRZ signaling coordinates aspects of copulation and fecundity in Drosophila (29, 30) and steroid synthesis in Octopus gonads (31).”
From Corazonin signaling integrates energy homeostasis and lunar phase to regulate aspects of growth and sexual maturation in Platynereis (2020) · cites this paper as [31]
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Cites
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GnRH and GnRH receptors in metazoa: A historical, comparative, and evolutive perspective
Kah, O., Lethimonier, C., Somoza, G. M., Guilgur, L. G., Vaillant, C., & Lareyre, J. (2007) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2007.01.030 · Cited by 262
Evolution of GnRH: Diving deeper
Roch, G. J., Busby, E. R., & Sherwood, N. M. (2011) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2010.12.014 · Cited by 225
Cephalopod Brains: An Overview of Current Knowledge to Facilitate Comparison With Vertebrates
Shigeno, S., Andrews, P. L. R., Ponte, G., & Fiorito, G. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00952 · Cited by 182
Castro, L. F. C., Lima, D., Machado, A., Melo, C. A., Hiromori, Y., Nishikawa, J., Nakanishi, T., Reis-Henriques, M. A., & Santos, M. M. (2007) · Aquatic Toxicology · doi:10.1016/j.aquatox.2007.07.016 · Cited by 171
Metadata
- Authors
- Kanda, A., Takahashi, T., Satake, H., & Minakata, H.
- Affiliations
- Suntory Institute for Bioorganic Research, 1-1-1 Wakayamadai, Shimamoto-cho, Mishima-gun, Osaka 618-8503, Japan
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 2006-03-15
- Volume
- 395
- Issue
- 1
- Pages
- 125-135
- ISSN
- 0264-6021 (ISSN-L)
- 1470-8728
- OpenAlex
- W2086669857
- Cited by
- 122
- References
- 39
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 5 · 2023: 6 · 2022: 1 · 2021: 5 · 2020: 5 · 2019: 8 · 2018: 4 · 2017: 7 · 2016: 8 · 2015: 11 · 2014: 3 · 2013: 10 · 2012: 10
- FWCI
- 8.11
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Biochemical Journal (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Reproductive biology and impacts on aquatic species
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- GnRH receptor, Octopus vulgaris, octopus, steroidogenesis, reproductive control, neurotransmitters, neuromodulators, intron positions, cephalopod reproduction
- MeSH terms
- Amino Acid Sequence, Animals, Brain, Cloning, Molecular, Exons, Introns, Ligands, Male, Molecular Sequence Data, Oocytes, Phylogeny, Receptors, LHRH, RNA, Messenger, Gonadal Steroid Hormones, Spermatozoa, Xenopus, Sequence Alignment, Protein Structure, Tertiary, Sequence Analysis, Protein, Gene Expression Profiling, Protein Transport, Octopodiformes
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