Role of MAP1B in axonal retrograde transport of mitochondria
Open accessAbstract
The MAPs (microtubule-associated proteins) MAP1B and tau are well known for binding to microtubules and stabilizing these structures. An additional role for MAPs has emerged recently where they appear to participate in the regulation of transport of cargos on the microtubules found in axons. In this role, tau has been associated with the regulation of anterograde axonal transport. We now report that MAP1B is associated with the regulation of retrograde axonal transport of mitochondria. This finding potentially provides precise control of axonal transport by MAPs at several levels: controlling the anterograde or retrograde direction of transport depending on the type of MAP involved, controlling the speed of transport and controlling the stability of the microtubule tracks upon which transport occurs.
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Genetic deletion studies indicate that endogenous tau participates in neuronal processes including cytoskeletal regulation, mitochondrial dynamics, synaptic plasticity, network activity, and DNA/RNA stability.
“Genetic deletion studies indicate that endogenous tau participates in a range of neuronal processes, including cytoskeletal regulation, mitochondrial dynamics, synaptic plasticity, network activity [10–22], and stability of DNA and RNA stability [23].”
From Tau Ablation Rewires Brain Cell Programs in Health and Restores Function in Disease (2026) · cites this paper as [17]
The mitochondrial-movement results (page unavailable) compare wild-type and tau-knockout neurons and report faster anterograde movement and less pausing without tau, supporting the mitochondrial-dynamics part of the claim. The Discussion (page unavailable) also describes a possible structural role for tau in microtubule stabilization. This paper does not establish roles in synaptic plasticity or network activity; the sentence separately cites [23] for DNA/RNA stability. (LLM, conf=0.85)
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Cites
Rat hippocampal neurons in dispersed cell culture.
Banker, G. A., & Cowan, W. M. (1977) · Brain Research · doi:10.1016/0006-8993(77)90594-7 · Cited by 1,110 · see citing works
Martin, M., Iyadurai, S. J., Gassman, A., Gindhart, J. G., Hays, T. S., & Saxton, W. M. (1999) · Molecular Biology of the Cell · doi:10.1091/mbc.10.11.3717 · Cited by 365 · see citing works
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Research works printed but not linked: 2
- Kosik, K. S. (1997) in Brain Microtubule Associated (Avila, J., Brandt, R. and Kosik, K. S., eds.), pp. 43-52, Harwood Academic Publ. GmbH., Poststrasse 22, 7000 Chur, Switzerland
- Brady, S. T., Pfister, K. K. and Bloom, G. S. (1990) A monoclonal antibody against kinesin inhibits both anterograde and retrograde fast axonal transport in squid axoplasm. Proc. Natl. Acad. Sci. U.S.A. 87, 1061-1065
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Tau Ablation Rewires Brain Cell Programs in Health and Restores Function in Disease
Chimal-Juárez, E., Patel, H., Jury-Garfe, N., Dabin, L. C., Vidal, R., Kim, J., & Lasagna-Reeves, C. A. (2026) · bioRxiv · doi:10.64898/2026.05.12.724684
- Authors
- Jiménez-Mateos, E.-M., González-Billault, C., Dawson, H. N., Vitek, M. P., & Avila, J.
- Affiliations
- Centro de Biología Molecular “Severo Ochoa”, Campus de Cantoblanco, Universidad Autónoma de Madrid, 28049 Madrid, Spain
- Centro de Biología Molecular Severo Ochoa (ES)
- Northwestern University (US)
- Duke University (US)
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 2006-06-14
- Volume
- 397
- Issue
- 1
- Pages
- 53-59
- ISSN
- 0264-6021 (ISSN-L)
- 1470-8728
- PMC
- PMC1479764
- OpenAlex
- W1976684979
- Cited by
- 70
- References
- 2
- Citations by year
- 2026: 1 · 2025: 3 · 2023: 4 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 4 · 2018: 6 · 2017: 9 · 2016: 2 · 2015: 3 · 2014: 6 · 2013: 4 · 2012: 4
- FWCI
- 2.07
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Biochemical Journal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (acceptedVersion, other-oa)
- HAL (submittedVersion, other-oa)
- Trinity's Access to Research Output (TARA) (Trinity College Dublin) (submittedVersion, other-oa)
- Funders
- Comunidad de Madrid
- Ministerio de Ciencia y Tecnología
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Keywords
- MAP1B, microtubule-associated proteins, axonal transport, tau protein, microtubule stabilization, anterograde transport, transport velocity, microtubule stability
- MeSH terms
- Animals, Axonal Transport, Cells, Cultured, Hippocampus, Mice, Inbred C57BL, Microtubule-Associated Proteins, Mitochondria, Mice
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