The DOI matches its Crossref record; 217 of the 226 references it cites were found in a registry or an index.
Signalling to translation: how signal transduction pathways control the protein synthetic machinery
Abstract
Recent advances in our understanding of both the regulation of components of the translational machinery and the upstream signalling pathways that modulate them have provided important new insights into the mechanisms by which hormones, growth factors, nutrients and cellular energy status control protein synthesis in mammalian cells. The importance of proper control of mRNA translation is strikingly illustrated by the fact that defects in this process or its control are implicated in a number of disease states, such as cancer, tissue hypertrophy and neurodegeneration. Signalling pathways such as those involving mTOR (mammalian target of rapamycin) and mitogen-activated protein kinases modulate the phosphorylation of translation factors, the activities of the protein kinases that act upon them and the association of RNA-binding proteins with specific mRNAs. These effects contribute both to the overall control of protein synthesis (which is linked to cell growth) and to the modulation of the translation or stability of specific mRNAs. However, important questions remain about both the contributions of individual regulatory events to the control of general protein synthesis and the mechanisms by which the translation of specific mRNAs is controlled.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“This foundational correlation remains statistically strong [15,17] and has been corroborated by seminal work validating RNA accumulation alongside MPS kinetics [16,70].”
From Ribosome Biogenesis as a Putative Bottleneck to Skeletal Muscle Hypertrophy: Mechanisms, Human Evidence, and Practical Modulators (2026) · cites this paper as [17]
Citations
Cites
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
Sarbassov, D. D., Guertin, D. A., Ali, S. M., & Sabatini, D. M. (2005) · Science · doi:10.1126/science.1106148 · Cited by 6,216
TOR signaling in growth and metabolism
Wullschleger, S., Loewith, R., & Hall, M. N. (2006) · Cell · doi:10.1016/j.cell.2006.01.016 · Cited by 5,787
TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival
Inoki, K., Zhu, T., & Guan, K.-L. (2003) · Cell · doi:10.1016/s0092-8674(03)00929-2 · Cited by 3,914
Regulated Translation Initiation Controls Stress-Induced Gene Expression in Mammalian Cells
Harding, H. P., Novoa, I., Zhang, Y., Zeng, H., Wek, R. C., Schapira, M., & Ron, D. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00108-8 · Cited by 3,344
Roux, P. P., & Blenis, J. (2004) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.68.2.320-344.2004 · Cited by 2,540
Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB
Sarbassov, D. D., Ali, S. M., Sengupta, S., Sheen, J.-H., Hsu, P. P., Bagley, A. F., Markhard, A. L., & Sabatini, D. M. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.03.029 · Cited by 2,365
eIF4 Initiation Factors: Effectors of mRNA Recruitment to Ribosomes and Regulators of Translation
Gingras, A., Raught, B., & Sonenberg, N. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.913 · Cited by 2,103
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
Jacinto, E., Loewith, R., Schmidt, A., Lin, S., Rüegg, M. A., Hall, A., & Hall, M. N. (2004) · Nature Cell Biology · doi:10.1038/ncb1183 · Cited by 2,097
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
Um, S. H., Frigerio, F., Watanabe, M., Picard, F., Joaquin, M., Sticker, M., Fumagalli, S., Allegrini, P. R., Kozma, S. C., Auwerx, J., et al. (2004) · Nature · doi:10.1038/nature02866 · Cited by 1,677
Growing roles for the mTOR pathway
Sarbassov, D. D., Ali, S. M., & Sabatini, D. M. (2005) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2005.09.009 · Cited by 1,590
Research works printed but not linked: 5
- Hinnebusch, 2000, Mechanism and regulation of methionyl-tRNA binding to ribosomes, 185
- Pestova, 2006, The mechanism of translation initiation in eukaryotes, 87
- Dever, 2006, The eIF2α kinases, 319
- Klann, 2006, Protein synthesis and translational control in synaptic plasticity and learning and memory, 485
- Shantz, 1994, Regulation of ornithine decarboxylase (ODC) expression by translation initiation factor eIF-4E, FASEB J., 8, A1309
Cited by
Sorted by citations
Items 501–518 of 518
Regulation of energy metabolism by eEF2K in tumor cells
Wang, J. (2023) · International Conference on Modern Medicine and Global Health (ICMMGH) · doi:10.1117/12.2692913
Physiologische und molekulare Anpassungen an Krafttraining
Ahtiainen, J. P. (2023) · Springer eBooks · doi:10.1007/978-3-031-36310-8_5
Dhume, M. M. S. (2023) · Indian Journal of Pathology and Oncology · doi:10.18231/j.ijpo.2023.076
The effects of LPS plus pro-inflammatory cytokines on glycogen synthesis in C2C12 myocytes
de Rivera, R., & Francois-Xavier, P. G. (2011) · UPT. Syiah Kuala University Library (Syiah Kuala University)
The metabolic and functional consequences of hyperammonaemia
Wilkinson, D. J. (2012) · University of Brighton Repository (University of Brighton)
Mansley, M. K. (2010) · Discovery Research Portal (University of Dundee)
Hughes, A. K., Francis, T., Marjoram, L., Rooney, J. H., Ellison, G. M., Pollock, R., Curtis, M. J., Cape, A., Larsen, M. S., Phillips, B. E., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26596994
Hughes, A. K., Francis, T., Marjoram, L., Rooney, J. H., Ellison, G. M., Pollock, R., Curtis, M. J., Cape, A., Larsen, M. S., Phillips, B. E., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26596991
Hughes, A. K., Francis, T., Marjoram, L., Rooney, J. H., Ellison, G. M., Pollock, R., Curtis, M. J., Cape, A., Larsen, M. S., Phillips, B. E., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26596997
Réseau de contrôle de la traduction par l'Hormone Folliculo-Stimulante
Huamán, K. B. L. (2013) · theses.fr (ABES) · doi:10.70675/d4a25518z7516z44aez84b3zf8a0eb211064
Yeganeh, S., Vahdat, S., Asrami, M. B., & Nikoo, M. (2026) · Aquacultural Engineering · doi:10.1016/j.aquaeng.2026.102785
Defects in ribosomes and translational control in lymphoid leukemia and lymphoma
Caruso, M., Pasau, N., Herranz, Ó., & Keersmaecker, K. D. (2026) · Seminars in Hematology · doi:10.1053/j.seminhematol.2026.09.002
Metadata
- Authors
- Proud, C. G.
- Affiliations
- University of British Columbia (CA)
- Corresponding author
- Proud, Christopher G.
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 2007-03-26
- Volume
- 403
- Issue
- 2
- Pages
- 217-234
- ISSN
- 0264-6021 (ISSN-L)
- 1470-8728
- OpenAlex
- W2080451230
- Cited by
- 520
- References
- 226
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 8 · 2023: 10 · 2022: 10 · 2021: 11 · 2020: 14 · 2019: 17 · 2018: 21 · 2017: 20 · 2016: 21 · 2015: 26 · 2014: 29 · 2013: 37 · 2012: 50
- FWCI
- 4.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical Journal (publishedVersion)
- PubMed (publishedVersion)
- ePrints Soton (University of Southampton) (submittedVersion)
- Funders
- Wellcome Trust
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Keywords
- translational regulation, signal transduction, protein synthesis, mTOR, mitogen-activated protein kinase, RNA-binding proteins, mRNA stability, cell growth, nutrient signaling, energy status, hormone signaling, growth factor signaling, cancer, neurodegeneration, tissue hypertrophy
- MeSH terms
- Animals, Humans, Protein Binding, Ribosomes, Protein Biosynthesis, Signal Transduction, RNA-Binding Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
