The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Antiparallel β-sheet: a signature structure of the oligomeric amyloid β-peptide
Open accessAbstract
AD (Alzheimer's disease) is linked to Aβ (amyloid β-peptide) misfolding. Studies demonstrate that the level of soluble Aβ oligomeric forms correlates better with the progression of the disease than the level of fibrillar forms. Conformation-dependent antibodies have been developed to detect either Aβ oligomers or fibrils, suggesting that structural differences between these forms of Aβ exist. Using conditions which yield well-defined Aβ-(1–42) oligomers or fibrils, we studied the secondary structure of these species by ATR (attenuated total reflection)–FTIR (Fouriertransform infrared) spectroscopy. Whereas fibrillar Aβ was organized in a parallel β-sheet conformation, oligomeric Aβ displayed distinct spectral features, which were attributed to an antiparallel β-sheet structure. We also noted striking similarities between Aβ oligomers spectra and those of bacterial outer membrane porins. We discuss our results in terms of a possible organization of the antiparallel β-sheets in Aβ oligomers, which may be related to reported effects of these highly toxic species in the amyloid pathogenesis associated with AD.
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Cites
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Cited by
Lee, S. J. C., Nam, E., Lee, H. J., Savelieff, M. G., & Lim, M. H. (2017) · Chemical Society Reviews · doi:10.1039/c6cs00731g · Cited by 576
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Stabilization of neurotoxic Alzheimer amyloid-β oligomers by protein engineering
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Protein misfolding and aggregation in Alzheimer’s disease and type 2 diabetes mellitus
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Metadata
- Authors
- Cerf, E., Sarroukh, R., Tamamizu-Kato, S., Breydo, L., Derclaye, S., Dufrêne, Y. F., Narayanaswami, V., Goormaghtigh, E., Ruysschaert, J.-M., & Raussens, V.
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 2009-07-15
- Volume
- 421
- Issue
- 3
- Pages
- 415-423
- ISSN
- 0264-6021 (ISSN-L)
- 1470-8728
- OpenAlex
- W2001148193
- Cited by
- 494
- References
- 48
- FWCI
- 15.55
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Cerf, E., Sarroukh, R., Tamamizu-Kato, S., Breydo, L., Derclaye, S., Dufrêne, Y. F., Narayanaswami, V., Goormaghtigh, E., Ruysschaert, J.-M., & Raussens, V. (2009). Antiparallel β-sheet: a signature structure of the oligomeric amyloid β-peptide. Biochemical Journal. https://doi.org/10.1042/bj20090379
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